Results 141 to 150 of about 17,995 (192)

Role of cholecystokinin-A and cholecystokinin-B receptors in anxiety

Amino Acids, 2002
Evidence from several laboratories indicates that the anxiogenic effects of cholecystokinin (CCK) are mediated by CCKB receptors. However, it has been reported that CCKA receptors have been found in brain and CCKA antagonists have anxiolytic properties.
A M, Hernandez-Gómez, R, Aguilar-Roblero, M, Pérez de la Mora   +2 more
openaire   +2 more sources

Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene polymorphisms in Parkinson's disease

Pharmacogenetics, 2003
Cholecystokinin modulates the release of dopamine and dopamine-related behaviours in the mesolimbic pathway, where cholecystokinin and dopamine coexist in dopaminergic neurones. Because cholecystokinin and its receptors (A and B) have a functional interaction with dopaminergic neurotransmission, alterations in them may constitute a predisposition for ...
Jian, Wang, Yan-Mei, Si, Zhuo-Lin, Liu, Long, Yu   +3 more
openaire   +2 more sources

Localization of cholecystokinin A and cholecystokinin B-gastrin receptors in the human stomach

Gastroenterology, 1997
Gastrin and cholecystokinin (CCK) are gut-brain peptides, with multiple functions in the gastrointestinal tract mediated through CCK-B-gastrin and CCK-A receptors. The receptor localization is, however, not well established in humans. The aim of this study was to investigate the distribution and pharmacological characteristics of CCK-A and CCK-B ...
Reubi JC, Waser B, Läderach U, Stettler C, Friess H, Halter F, Schmassmann A   +6 more
openaire   +3 more sources

Radiolabeling approaches for cholecystokinin B receptor imaging

Peptide Science, 2002
AbstractRegulatory peptides and their analogs are being extensively investigated as radiopharmaceuticals for cancer imaging. In particular, cholecystokinin (CCK) receptors of the subtype B (CCK‐BR) have been shown to be overexpressed in certain neuroendocrine tumors including medullary thyroid cancer.
ALOJ L., PANICO M. R., CARACÒ C., ZANNETTI A., DEL VECCHIO, SILVANA, DI NUZZO C., ARRA C., MORELLI, GIANCARLO, TESAURO, DIEGO, DE LUCA S., PEDONE C., SALVATORE, MARCO   +11 more
openaire   +6 more sources

Cholecystokinin- and cholecystokinin-B-receptor gene polymorphisms in panic disorder

2004
Panic disorder like other neuropsychiatric disorders is believed to be caused by multiple psychosocial and biological factors. Several lines of evidence point to a role for the peptide neurotransmitter cholecystokinin in the pathogenesis of panic disorder.
V G, Hösing, A, Schirmacher, G, Kuhlenbäumer, C, Freitag, P, Sand, C, Schlesiger, C, Jacob, J, Fritze, P, Franke, M, Rietschel, H, Garritsen, M M, Nöthen, R, Fimmers, F, Stögbauer, J, Deckert   +14 more
openaire   +4 more sources

On the distribution of cholecystokinin B receptors in monkey brain

Brain Research, 1996
In view of recent evidence for a role for the B subtype of cholecystokinin (CCKB) receptor in panic and anxiety, the distribution of CCKB receptors in the forebrain of a Rhesus macaca monkey was examined by receptor autoradiography employing [125I]D-Tyr25(Nleu28,31)-CCK25-33S. CCKB receptors were widely and topographically distributed in cortex.
L D, Mercer, P M, Beart, M K, Horne, D I, Finkelstein, P, Carrive, G, Paxinos   +5 more
openaire   +2 more sources

Characterization of Cholecystokinin Receptors and Messenger RNA Expression in Rat Pancreas: Evidence for Expression of Cholecystokinin-A Receptors but Not Cholecystokinin-B (Gastrin) Receptors

Journal of Surgical Research, 1995
It has been previously demonstrated that guinea pig pancreas possesses both cholecystokinin-A (CCK-A) receptors and CCK-B (gastrin) receptors. In contrast to guinea pig pancreas, it is not known whether CCK receptors in rat pancreas are CCK-A receptors, CCK-B (gastrin) receptors, or both.
W, Zhou, S P, Povoski, R H, Bell
openaire   +2 more sources

Ligands for Cholecystokinin A and Cholecystokinin B/Gastrin Receptors

1991
Publisher Summary This chapter describes the radioligand binding assay methods used to identify and characterize the interaction of agents with the cholecystokinin-A (CCK-A) and CCK-B/gastrin receptor subtypes. The chapter also discusses the biochemical and pharmacological properties of nonpeptide CCK-A and CCK-B/gastrin antagonists, and their ...
Raymond S.L. Chang, Victor J. Lotti
openaire   +1 more source

Characterization of cloned human cholecystokinin-B receptor as a gastrin receptor

Biochemical Pharmacology, 1994
The cholecystokinin (CCK)-B receptor cloned from human brain was characterized as a gastrin receptor by using heterologous expression systems of COS-7 cells and Xenopus oocytes. 125I-gastrin binding to human CCK-B receptor expressed in COS-7 was time-dependent, saturable and also specific, as well as 125-I-CCK-8.
A, Miyake, S, Mochizuki, H, Kawashima
openaire   +2 more sources

The role of the ‘central’ cholecystokinin-B receptor in panic disorder

Acta Neuropsychiatrica, 1996
SummaryResearch investigating the neurobiological underpinnings of anxiety disorder have mainly been focused on dysfunction of the GABA, noradrenergic and serotonergic (5-HT) neuronal systems. Just recently, in both animal and human studies, evidence has been found for a possible role of the cholecystokinin (CCK) neuronal system in the pathogenesis of ...
Van Megen, H J G M, Westenberg, H G M, Den Boer, J A   +2 more
openaire   +3 more sources