Results 151 to 160 of about 17,995 (192)

Localization of cholecystokinin A and cholecystokinin B/ gastrin receptors in the canine upper gastrointestinal tract

Gastroenterology, 1994
Cholecystokinin (CCK) is a neuropeptide that exerts numerous effects in the gut. To determine the sites of action of CCK, the distribution and properties of CCK receptor subtypes were studied.CCK receptors were localized by autoradiographic analysis of 125I-CCK binding to frozen sections of the canine upper gastrointestinal tract.In the cardiac and ...
C R, Mantyh, T N, Pappas, S R, Vigna
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Cholecystokinin A and B Receptor mRNA Expression in Human Pancreas

Pancreas, 1999
Little information is available on the expression of cholecystokinin (CCK) receptors in the human pancreas, especially in the developing pancreas. We evaluated expression patterns for the CCK receptors in human pancreas at three different ages: fetus, infant, and adult.
I, Nishimori, M, Kamakura, K, Fujikawa-Adachi, M, Nojima, S, Onishi, M A, Hollingsworth, A, Harris   +6 more
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Caerulein may potentiate morphine-induced antinociception by cholecystokinin-A and/or cholecystokinin-B receptor mechanisms

General Pharmacology: The Vascular System, 1997
1. The effects of a cholecystokinin agonist and antagonist on morphine antinociception in the tail-flick test have been evaluated. 2. The administration of different doses of caerulein (0.01, 0.05 and 0.1 mg/kg) 30 min prior to morphine (1.5, 3 and 6 mg/kg) increased the antinociception induced by morphine in mice. 3.
M, Rezayat, S, Oreizi, M R, Zarrindast
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Overexpression of Cholecystokinin-B/ Gastrin Receptor Gene in the Stomach of Naturally Occurring Cholecystokinin-A Receptor Gene Knockout Rats

Digestion, 1998
We examined the cholecystokinin (CCK)-B/gastrin receptor, H⁺/K⁺-ATPase and somatostatin gene expression, the histology and immunohistochemistry of gastrin and somatostatin of the stomach, plasma gastrin levels, and gastric acid secretion in naturally occurring CCK-A receptor gene knockout (Otsuka Long-Evans
K, Miyasaka, S, Kanai, M, Ohta, A, Jimi, A, Kono, A, Funakoshi   +5 more
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Identification and characterization of various cholecystokinin B receptor mRNA forms in rat brain tissue and determination of the cholecystokinin B receptor gene structure

Neuropeptides, 1994
Abstract: Using the powerful method of DNA amplification, we have been able to isolate several cholecystokinin B (CCKB) receptor (CCKB‐R) mRNA forms from rat brain tissue, allowing the detection of a truncated mRNA species and the determination of the CCKB‐R gene structure.
Jagerschmidt, A., Popovici, T., O'Donohue, Michael, Roques, B.   +3 more
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Cholecystokinin-B/gastrin receptor-targeting peptides for staging and therapy of medullary thyroid cancer and other cholecystokinin-B receptor-expressing malignancies

Seminars in Nuclear Medicine, 2002
The high sensitivity of the pentagastrin stimulation test in detecting primary or metastatic medullary thyroid cancer (MTC) suggests a widespread expression of the corresponding receptor type on human MTC. Indeed, autoradiographic studies demonstrated cholecystokinin (CCK)-B/gastrin receptors not only in more than 90% of MTCs, but also in a high ...
Thomas M, Behr, Martin P, Béhé
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Expression of Cholecystokinin-B/Gastrin Receptors in Medullary Thyroid Cancer

The European Journal of Surgery, 1999
To characterise the cholecystokinin (CCK) receptor subtypes in medullary thyroid cancer by measuring the expression of CCK-A and CCK-B/gastrin receptor mRNA.Open study.Teaching hospital, Sweden.6 patients with medullary thyroid cancer.Pentagastrin stimulation test and measurement of calcitonin concentration. Biopsy specimens were analysed using reverse
A, Amiri-Mosavi, H, Ahlman, L E, Tisell, B, Wängberg, L, Kölby, E, Forssell-Aronsson, P A, Lundberg, G, Lindstedt, O, Nilsson   +8 more
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Cholecystokinin CCKB receptor mRNA isoforms

NeuroReport, 1999
In the light of earlier findings of reduced cholecystokinin (CCK) peptide and CCK mRNA levels in the cerebral cortex, we have used in situ hybridization to examine possible regulation of mRNAs coding for two isoforms of the CCK(B) receptor in frontal cortex (Brodmann's area 10) of schizophrenic patients.
O, Zachrisson, J, de Belleroche, K R, Wendt, S, Hirsch, N, Lindefors   +4 more
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A water soluble benzazepine cholecystokinin-B receptor antagonist

Bioorganic & Medicinal Chemistry Letters, 1995
Abstract A series of 5-substituted-3-ureidobenzazepin-2-ones bearing ioizable functionality was synthesized as potential cholecystokinin-B (CCK-B) receptor antagonists. SAR of this series of compounds demonstrated the optimal combination of a carboxylic acid and 5-cyclohexyl group, providing the high affinity (CCK-B IC 50 = 0.10 nM), water soluble ...
John A. Lowe, Susan E. Drozda, Stafford McLean, Dianne K. Bryce, Rosemary T. Crawford, Stevin Zorn, Jean Morrone, Troy A. Appleton, Franco Lombardo   +8 more
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Cardiovascular Effects of Cholecystokinin-4 Are Mediated By the Cholecystokinin-B Receptor Subtype In the Conscious Guinea Pig and Dog

The Journal of Pharmacology and Experimental Therapeutics, 1997
Panicogenic effects in humans of the selective cholecystokinin (CCK(B)) receptor agonist, cholecystokinin tetrapeptide (CCK4), have been reported to correlate with increases in heart rate (HR) and mean arterial pressure (MAP). Previous investigators have demonstrated that the nonselective CCK(A) and CCK(B) receptor agonist, sulfated cholecystokinin ...
A A, Fossa, M J, DePasquale, J, Morrone, S H, Zorn, D, Bryce, J A, Lowe, S, McLean   +6 more
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