Results 41 to 50 of about 17,995 (192)

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

The Role of Cholecystokinin in Peripheral Taste Signaling in Mice

Frontiers in Physiology, 2017
Cholecystokinin (CCK) is a gut hormone released from enteroendocrine cells. CCK functions as an anorexigenic factor by acting on CCK receptors expressed on the vagal afferent nerve and hypothalamus with a synergistic interaction between leptin.
Ryusuke Yoshida, Ryusuke Yoshida, Misa Shin, Misa Shin, Keiko Yasumatsu, Keiko Yasumatsu, Shingo Takai, Mayuko Inoue, Mayuko Inoue, Noriatsu Shigemura, Soichi Takiguchi, Seiji Nakamura, Yuzo Ninomiya, Yuzo Ninomiya, Yuzo Ninomiya   +14 more
doaj   +1 more source

DIFFERENCES IN ETHANOL INGESTION BETWEEN CHOLECYSTOKININ-A RECEPTOR DEFICIENT AND -B RECEPTOR DEFICIENT MICE [PDF]

Alcohol and Alcoholism, 2005
Cholecystokinin (CCK) modulates dopamine release in the nucleus accumbens through the CCK-A receptor (CCK-AR). The dopaminergic neurotransmission between the ventral tegmental area and the limbic forebrain is a critical neurobiological component of alcohol and drug self-administration.
Kyoko, Miyasaka, Hiroko, Hosoya, Saeko, Takano, Minoru, Ohta, Ayako, Sekime, Setsuko, Kanai, Toshimitsu, Matsui, Akihiro, Funakoshi   +7 more
openaire   +2 more sources

Significant reduction of activity retention in the kidneys via optimized linker sequences in radiohybrid-based minigastrin analogs

EJNMMI Research
Background We recently introduced radiohybrid (rh)-based minigastrin analogs e.g., DOTA-rhCCK-18 (DOTA-D-Dap(p-SiFA)-(D-γ-Glu)8-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH2), that revealed substantially increased activity retention in the tumor.
Nadine Holzleitner, Sebastian Fischer, Isabel Maniyankerikalam, Roswitha Beck, Constantin Lapa, Hans-Jürgen Wester, Thomas Günther   +6 more
doaj   +1 more source

The Expressing Patterns of Opioid Peptides, Anti-opioid Peptides and Their Receptors in the Central Nervous System Are Involved in Electroacupuncture Tolerance in Goats

Frontiers in Neuroscience, 2018
To investigate dynamic processes of enkephalin (ENK), cholecystokinin octapeptide (CCK-8), orphanin FQ (OFQ) and their receptors (μ opioid receptor, MOR; CCK B type receptor, CCKBR and opioid receptor-like 1 receptor, OPRL1) in the central nerve system ...
Juan Wan, Zhengying Qiu, Zhengying Qiu, Yi Ding, Sha Nan, Mingxing Ding   +5 more
doaj   +1 more source

Postponement of Satiety by Blockade of Brain Cholecystokinin (CCK-B) Receptors

Science, 1989
Exogenous cholecystokinin (CCK) decreases food intake and causes satiety in animals and man. However, it has not been established that endogenous CCK causes satiety or whether the response is mediated by peripheral-type (CCK-A) or brain-type (CCK-B) receptors.
Dourish, C, Rycroft, W, Iversen, S
openaire   +2 more sources

Energy Metabolism and Turnover Are Increased in Mice Lacking the Cholecystokinin-B Receptor [PDF]

The Journal of Nutrition, 2002
Cholecystokinin (CCK) is an important gastrointestinal hormone as well as a neurotransmitter. Two types of CCK receptors, types A and B, have been identified. The CCK-A receptor is involved in satiety, food intake and behavior, whereas the B receptor is involved in anxiety.
Kyoko, Miyasaka, Mineko, Ichikawa, Minoru, Ohta, Setsuko, Kanai, Yuki, Yoshida, Masao, Masuda, Aki, Nagata, Toshimitsu, Matsui, Tetsuo, Noda, Soichi, Takiguchi, Yutaka, Takata, Takako, Kawanami, Akihiro, Funakoshi   +12 more
openaire   +2 more sources

Postprandial Glycemic Control With Automated Insulin Delivery With Control‐IQ Technology: The Impact of Meal Composition

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To evaluate the efficiency of the AID system with Control‐IQ technology and carbohydrate counting (CHC)–based premeal bolus to control postprandial glucose (PPG) after mixed meals with different macronutrient compositions in adolescents with type 1 diabetes (T1D).
Marco Marigliano, Claudia Piona, Elisa Morotti, Maddalena Macedoni, Parto Kharazizadeh, Valentina Mancioppi, Francesca Tomasselli, Mara Tommasi, Claudio Maffeis   +8 more
wiley   +1 more source

Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling

Frontiers in Pharmacology, 2020
Ischemic/reperfusion (I/R) injury is the primary cause of acute kidney injury (AKI). Gastrin, a gastrointestinal hormone, is involved in the regulation of kidney function of sodium excretion. However, whether gastrin has an effect on kidney I/R injury is
Chao Liu, Chao Liu, Ken Chen, Ken Chen, Huaixiang Wang, Ye Zhang, Ye Zhang, Xudong Duan, Yuanzheng Xue, Yuanzheng Xue, Hongye He, Hongye He, Yu Huang, Yu Huang, Zhi Chen, Zhi Chen, Hongmei Ren, Hongmei Ren, Hongyong Wang, Hongyong Wang, Chunyu Zeng, Chunyu Zeng, Chunyu Zeng, Chunyu Zeng   +23 more
doaj   +1 more source

A cholecystokinin B receptor antagonist and cocaine interaction, phase I study [PDF]

CNS Neuroscience & Therapeutics, 2018
SummaryAimsRPR102681, a cholecystokinin‐B antagonist, increased dopamine (DA) release and reduced cocaine self‐administration in animals. This pilot study sought to assess the safety and pharmacokinetics (PK) of co‐administration ofRPR102681 and cocaine, and to confirm the DA release mechanism ofRPR102681.MethodsSixteen cocaine‐dependent participants ...
Ahmed Elkashef, James Robert Brašić, Louis R. Cantelina, Roberta Kahn, Nora Chiang, Weiguo Ye, Yun Zhou, Jurij Mojsiak, Kimberly R. Warren, Andrew Crabb, John Hilton, Dean F. Wong, Frank Vocci   +12 more
openaire   +2 more sources