Results 1 to 10 of about 93,761 (300)

Expression of Endothelin-1, Endothelin Receptor-A, and Endothelin Receptor-B in facial melasma compared to adjacent skin

Clinical, Cosmetic and Investigational Dermatology, 2023
Carolina Nunhez da Silva,1 Hélio Amante Miot,1 Tony Fernando Grassi,2 Luciane Alarcão Dias-Melício,2– 4 Leandro Santos,2,3 Ana Cláudia Cavalcante Espósito1 1Department of Dermatology, São Paulo State University (UNESP) - Medical School of Botucatu ...
da Silva CN, Miot HA, Grassi TF, Dias-Melício LA, Santos L, Espósito ACC   +5 more
doaj   +4 more sources

Cardiopulmonary bypass–mediated lung ischemia–reperfusion injury: A protective role of sitaxentan [PDF]

Journal of International Medical Research
Background Cardiopulmonary bypass is widely used in cardiac surgery but often leads to lung ischemia–reperfusion injury, a major cause of morbidity and mortality. Despite advances in critical care, effective prevention remains challenging.
Zhengjia Wang, Renshu Zhan, Liqun Mo, Yingying Zhang, Yirong Chen, Li Liu, Yiping Bai   +6 more
doaj   +2 more sources

Vascular derived endothelin receptor A controls endothelin-induced retinal ganglion cell death

Cell Death Discovery, 2022
Endothelin (EDN, also known as ET) signaling has been suggested to be an important mediator of retinal ganglion cell (RGC) death in glaucoma. Antagonism of EDN receptors (EDNRA and EDNRB, also known as ET-A and ET-B) prevented RGC death in mouse models ...
Olivia J. Marola, Gareth R. Howell, Richard T. Libby   +2 more
doaj   +4 more sources

Bosentan, a drug used in the treatment of pulmonary hypertension, can prevent development of osteoporosis [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): We examined the antiosteoporotic effect of bosentan (Bose) by radiographic, histopathological, and molecular methods.Materials and Methods: Rats were divided into 4 groups of 8 rats each: one control (Sham), one osteoporosis only (OP), and ...
Duygu Köse, Ahmet Köse, Zekai Halıcı, Elif Çadirci, Taha Tavaci, Muhammed Gürbüz, Adem Maman   +6 more
doaj   +1 more source

Endothelin-1 gene and endothelin receptor A gene polymorphisms in severe pulmonary hypertension associated with rheumatic mitral valve disease

Archives of Medical Science, 2022
Introduction Endothelin-1 (ET-1) gene polymorphisms are implicated in pathogenesis of idiopathic pulmonary arterial hypertension Material and methods We studied ET-1 (Lys198Asn and 3A/4A) and endothelin receptor A (ETA) gene (His323His) polymorphisms in
Pratishtha Mehra, Vimal Mehta, Jamal Yusuf, Rishi Sukhija, Wilbert S. Aronow   +4 more
doaj   +1 more source

Endocan, ET-1, and ETAR Expression Profiles in Unicystic Ameloblastoma, Multicystic Ameloblastoma, and Ameloblastic Carcinoma [PDF]

Middle East Journal of Cancer, 2019
Background: Odontogenic lesions range from simple cysts to benign tumors and carcinomas. Unicystic ameloblastoma is a monocystic lesion and a less aggressive tumor compared to multicystic ameloblastoma.
Soussan Irani, Zhaleh Mohsenifar
doaj   +1 more source

Endothelin‐receptor interactions [PDF]

FEBS Letters, 1993
The mechanism of action of endothelin‐receptor interactions was studied, using radioligand binding assays and SDS‐PAGE, to investigate the possibility of disulfide interchange. Electrophoretic analysis suggested involvement of disulfide bond(s) in the receptor‐ligand complex.
Spinella, Michael J., Kottke, Rebecca, Magazine, Harold I., Healy, Matthew S., Catena, John A., Wilken, Philip, Andersen, Thomas T.   +6 more
openaire   +2 more sources

Genetic interactions between neurofibromin and endothelin receptor B in mice. [PDF]

PLoS ONE, 2013
When mutations in two different genes produce the same mutant phenotype, it suggests that the encoded proteins either interact with each other, or act in parallel to fulfill a similar purpose.
Mugdha Deo, Jenny Li-Ying Huang, Catherine D Van Raamsdonk   +2 more
doaj   +1 more source

Endothelin B receptor-mediated vasoconstriction induced by endothelin A receptor antagonist [PDF]

Cardiovascular Research, 1998
The vasoconstrictor effect of endothelins (ET) is mediated by endothelin A (ETA) and endothelin B (ETB) receptors. Furthermore, ETB receptor stimulation results in release of vasodilators. Hence, ETA receptor antagonists should attenuate ET-mediated vasoconstriction. The aim of the present study was to evaluate and compare the effects of BQ-123, an ETA
Zhang, Y., Oliver, J., Horowitz, J.
openaire   +3 more sources

EndothelinA-endothelinB receptor cross-talk and endothelin receptor binding [PDF]

Journal of Pharmacy and Pharmacology, 2011
AbstractBackground and objectiveThe magnitude of inhibition of an endothelin (ET)-1 response by selective blockade of the ETA or ETB receptors can be limited by apparent compensation mediated by the unblocked receptor. While the mechanism underlying this functionally defined interaction, or ‘cross-talk’, is not clear, binding studies suggest an ...
Robert M, Rapoport, Mario, Zuccarello
openaire   +2 more sources