Results 91 to 100 of about 44,776 (142)
Optimizing endothelin receptor antagonist use in the management of pulmonary arterial hypertension
Vascular Health and Risk Management, 2008 M Kathryn Steiner1, Ioana R Preston21Pulmonary Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; 2Pulmonary Critical Care and Sleep Division, Department of Medicine, Tufts Medical Center, Boston, MA, USAAbstract:
M Kathryn Steiner, Ioana R Preston
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Journal of Pharmacological Sciences, 2010 The mechanism for sustained Ca2+ influx activated by G protein–coupled receptors was examined. In Chinese hamster ovary cells expressing recombinant human endothelin type B receptor (ETBR) and endogenous P2Y receptor (P2Y-R), endothelin-1 elicited a ...
Tsunaki Higa +7 more
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Journal of Pharmacological Sciences, 2019 Endothelin type A receptor (ETAR) is internalized upon agonist stimulation; however, the mechanism thereof remains controversial. In this study, we characterized the endothelin-1 (ET-1)-induced internalization of ETAR expressed in Chinese hamster ovary ...
Takahiro Horinouchi +4 more
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Clarifying endothelin type B receptor function [PDF]
, 2006 Pollock, D.M., Schneider, M.P.
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Endothelin and other mediators in the pathophysiology of portal hypertension [PDF]
, 1998 Bilzer, Manfred +2 more
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Pathophysiological Roles of Endothelin Receptors in Cardiovascular Diseases
Journal of Pharmacological Sciences, 2012 Endothelin (ET)-1 derived from endothelial cells has a much more important role in cardiovascular system regulation than the ET-2 and ET-3 isoforms. Numerous lines of evidence indicate that ET-1 possesses a number of biological activities leading to ...
Mamoru Ohkita +3 more
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The anti-atherogenic effects of thiazolidinediones [PDF]
, 2007 The thiazolidinediones (TZDs) rosiglitazone (ROS) and pioglitazone (PIO) are insulin-sensitising agents widely used to treat patients with type 2 diabetes mellitus (T2DM). Thiazolidinediones significantly improve glycaemic control in diabetics by reduced
Honisett, Suzy +2 more
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The endothelin system in pulmonary and renal vasculopathy: les liaisons dangereuses
European Respiratory Review, 2009 Endothelial cells regulate vascular tone largely by the actions of endothelin-1. Endothelin-1 is a potent vasoconstrictor, with effects that are dependent on the receptors to which it binds as well as their location.
J-L Vachiéry, A. Davenport
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Safety and tolerability of bosentan in the management of pulmonary arterial hypertension
Drug Design, Development and Therapy, 2009 Kari E Roberts, Ioana R PrestonPulmonary, Critical Care and Sleep Medicine, Tufts Medical Center, Boston, Massachusetts, USAAbstract: Endothelin receptor antagonism has emerged as an important therapeutic approach in pulmonary arterial hypertension (PAH).
Kari E Roberts, Ioana R Preston
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