Results 91 to 100 of about 55,630 (278)

Envolvimento das endotelinas, atuando através de receptores ETa, na manifestação dos sintomas de colite experimental em modelos murinos [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2010Embora alguns estudos impliquem as endotelinas na patogênese das doenças inflamatórias intestinais ...
Claudino, Rafaela Franco
core  

Cardiopulmonary bypass–mediated lung ischemia–reperfusion injury: A protective role of sitaxentan

Journal of International Medical Research
Background Cardiopulmonary bypass is widely used in cardiac surgery but often leads to lung ischemia–reperfusion injury, a major cause of morbidity and mortality. Despite advances in critical care, effective prevention remains challenging.
Zhengjia Wang, Renshu Zhan, Liqun Mo, Yingying Zhang, Yirong Chen, Li Liu, Yiping Bai   +6 more
doaj   +1 more source

P10.01 INVOLVEMENT OF CALCIUM-CALMODULIN DEPENDENT PROTEIN KINASE II ON ENDOTHELIN RECEPTOR EXPRESSION IN CEREBRAL ARTERIES OF RAT

Artery Research, 2009
Background. Experimental cerebral ischemia and organ culture of cerebral arteries result in enhanced expression of endothelin ETB receptors in smooth muscle cells. The present study was designed to evaluate the involvement of calcium-calmodulin dependent
R. Waldsee, H. Ahnstedt, S. Eftekhari, L. Edvinsson   +3 more
doaj   +1 more source

Acute Pressor Response to Psychosocial Stress Is Dependent on Endothelium‐Derived Endothelin‐1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundAcute psychosocial stress provokes increases in circulating endothelin‐1 (ET‐1) levels in humans and animal models. However, key questions about the physiological function and cellular source of stress‐induced ET‐1 remain unanswered.
Brandon M. Fox, Bryan K. Becker, Analia S. Loria, Kelly A. Hyndman, Chunhua Jin, Hannah Clark, Robin Johns, Masashi Yanagisawa, David M. Pollock, Jennifer S. Pollock   +9 more
doaj   +1 more source

Intraoperative Cardiac Events During Pediatric Cardiac Magnetic Resonance Imaging Under Anesthesia: A Retrospective Cohort Study

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Children with congenital heart disease (CHD) frequently undergo cardiac magnetic resonance imaging (MRI) under anesthesia. Although these procedures lack surgical stimulus, patients remain physiologically vulnerable, and the incidence of perioperative cardiovascular instability in this setting is poorly defined.
Theodora Wingert, Justine Liang, Kelly Feldman, Amelie Delaporte, Christine Nguyen‐Buckley, Tristan Grogan, Alexandre Joosten, John Paul Finn, Ihab Ayad   +8 more
wiley   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Pathophysiological Roles of Endothelin Receptors in Cardiovascular Diseases

Journal of Pharmacological Sciences, 2012
Endothelin (ET)-1 derived from endothelial cells has a much more important role in cardiovascular system regulation than the ET-2 and ET-3 isoforms. Numerous lines of evidence indicate that ET-1 possesses a number of biological activities leading to ...
Mamoru Ohkita, Masashi Tawa, Kento Kitada, Yasuo Matsumura   +3 more
doaj   +1 more source

Biochemische und funktionelle Charakterisierung zellfrei exprimierter G-Protein-gekoppelter Rezeptoren des humanen Endothelin-Systems

, 2011
G-protein coupled receptors (GPCRs) are the key players in signal perception and transduction and one of the currently most important class of drug targets.
Junge, Friederike Alessandra
core  

Dor neuropática após lesão medular traumática: o papel dos receptores endotelinérgicos ETA e ETB [PDF]

, 2015
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2015.Lesões medulares traumáticas resultam em um dano neurológico que, geralmente, resulta em dor ...
Forner, Stefânia
core  

Ca2+ signal is involved in endothelin-1-induced internalization of endothelin type A receptor expressed in Chinese hamster ovary cells

Journal of Pharmacological Sciences, 2019
Endothelin type A receptor (ETAR) is internalized upon agonist stimulation; however, the mechanism thereof remains controversial. In this study, we characterized the endothelin-1 (ET-1)-induced internalization of ETAR expressed in Chinese hamster ovary ...
Takahiro Horinouchi, Sarita Karki, Koji Terada, Yuichi Mazaki, Soichi Miwa   +4 more
doaj   +1 more source