Results 251 to 260 of about 93,761 (300)

Internalization of Type-A Endothelin Receptor

Journal of Cardiovascular Pharmacology, 2000
Endothelins (ETs) are 21 amino acid peptides which bind to ET(A)- and ET(B)-receptors to evoke diverse physiological responses. This report studies the internalization of ET(A)-receptor in Chinese hamster ovary (CHO) cells which were stably transfected with ET(A)-receptor cDNA.
J, Wang, W J, Chiou, G D, Gagne, J R, Wu-Wong   +3 more
openaire   +2 more sources

Desensitization of Human Endothelin A Receptor

Journal of Cardiovascular Pharmacology, 1993
The response of G-protein-coupled receptors is modulated by homologous desensitization. Because endothelin A receptor (ETA) plays a part in vasoconstriction, the extent of desensitization and resensitization of endothelin responsiveness was studied.
C, Cyr, R M, Kris
openaire   +2 more sources

Development of a Photolabile Ligand for the Endothelin-A Receptor of Endothelin

Journal of Cardiovascular Pharmacology, 2000
Actions of endothelin (ET) are usually mediated through the so-called endothelin-A or -B (ET(A) or ET(B))-receptors. As part of our ongoing research program, we are studying the characterization of the ET(A)-receptor using specific photolabile ligands.
S, Tessier, C, Langlois, A, Brkovic, M, Coupal, A, De Léan, A, Fournier   +5 more
openaire   +2 more sources

Subtype-Specific Endothelin-A and Endothelin-B Receptor Desensitization Correlates with Differential Receptor Phosphorylation

Journal of Cardiovascular Pharmacology, 1998
In the rat cardiovascular system endothelin-1 (ET-1) elicits prolonged physiologic responses mediated by the ETA receptor, whereas the effects mediated by the ETB receptor are transient. The molecular mechanisms for the subtype-specific responses are not yet clear. However, post-translational modifications such as phosphorylation and palmitoylation may
H, Cramer, W, Müller-Esterl, C, Schroeder   +2 more
openaire   +2 more sources

Endothelin and endothelin receptors A and B in the human testis

Anatomy and Embryology, 1999
Human testicular capillaries interconnect Leydig cells and seminiferous tubules. Microcirculation and blood flow are therefore essential for the maintenance of spermatogenesis. The expression and the localisation of ET (endothelin) and its receptors in testicular tissue, in seminiferous tubules and in human testicular capillaries were studied.
S, Ergün, S, Harneit, H J, Paust, A K, Mukhopadhyay, A F, Holstein   +4 more
openaire   +2 more sources

Expression of Endothelin‐1 and Endothelin Receptor A in Canine Ovarian Tumours

Reproduction in Domestic Animals, 2010
ContentsOvarian tumours have a low incidence in bitch. Endothelin (ET‐1) and endothelin A receptor (ET‐A) are overexpressed in human ovarian cancer. Twenty canine ovarian tumours and five normal samples were first evaluated by western blotting and then immunohistochemically for ET‐1 and ET‐A expression.
BORZACCHIELLO, GIUSEPPE, Mogavero S, Tortorella G, Catone G, RUSSO, MARCO   +4 more
openaire   +4 more sources

Pharmacological knockout of endothelin ETA receptors

Life Sciences, 2003
We employed newly developed antagonists, which are specific for endothelin ET(A) receptors, to test whether this drug could mimic the phenotype of the mouse with corresponding gene knock out. Newborn rats, whose dams were given the ET(A) antagonist from day 7 of gestation, exhibited the typical ET(A)-lacking phenotypes like craniofacial abnormalities ...
Takanobu, Taniguchi, Ikunobu, Muramatsu
openaire   +2 more sources

Endothelin receptor antagonists: a brief review

Canadian Journal of Physiology and Pharmacology, 1994
The endothelins are a family of potent vasoconstrictors, some of which also have vasodilatory activity. In many diseases associated with tissue hypoxia or ischemia and in diseases in which vasoconstriction plays a role, the circulating levels of endothelin are higher than in healthy, control subjects.
openaire   +2 more sources

Endothelin-1, Endothelin-A- and Endothelin-B-receptor expression in preinvasive and invasive breast disease

Oncology Reports, 2004
Endothelin-1 (ET-1) is overexpressed in breast carcinomas and influences via its receptors (ETAR and ETBR) transformation, differentiation and growth processes in the human breast, but little is known about the ET expression in breast cancer precursors.
Pia, Wülfing, Raihanatou, Diallo, Christian, Kersting, Christian, Wülfing, Christopher, Poremba, Robert R, Greb, Werner, Böcker, Ludwig, Kiesel   +7 more
openaire   +2 more sources

Radioiodinated endothelin-1: a radiotracer for imaging endothelin receptor distribution and occupancy

Nuclear Medicine and Biology, 1999
Endothelin (ET) is one of the most potent vasoconstrictors known. Recently, ET has been implicated in various diseases, e.g., acute renal failure and congestive heart failure, which present the possibility of treating such diseases with endothelin receptor antagonists.
R E, Gibson, C, Fioravanti, B, Francis, H D, Burns   +3 more
openaire   +2 more sources