Results 31 to 40 of about 93,761 (300)

Protein kinase C inhibition attenuates vascular ET_B receptor upregulation and decreases brain damage after cerebral ischemia in rat

BMC Neuroscience, 2007
Background Protein kinase C (PKC) is known to be involved in the pathophysiology of experimental cerebral ischemia. We have previously shown that after transient middle cerebral artery occlusion, there is an upregulation of endothelin receptors in the ...
Vikman Petter, Stenman Emelie, Henriksson Marie, Edvinsson Lars   +3 more
doaj   +1 more source

Efficacy and safety of riociguat in combination therapy for patients with pulmonary arterial hypertension (PATENT studies)

Pulmonary Circulation, 2020
Many patients with pulmonary arterial hypertension do not achieve treatment goals with monotherapy, and therefore combination therapy is becoming the standard of care.
Hossein-Ardeschir Ghofrani, Ekkehard Grünig, Pavel Jansa, David Langleben, Stephan Rosenkranz, Ioana R. Preston, Franck Rahaghi, Namita Sood, Dennis Busse, Christian Meier, Marc Humbert   +10 more
doaj   +1 more source

Aberrant Expression of Histamine-independent Pruritogenic Mediators in Keratinocytes may be Involved in the Pathogenesis of Prurigo Nodularis

Acta Dermato-Venereologica, 2019
Prurigo nodularis is a highly pruritic and hyperplastic chronic dermatosis with unknown pathogenesis. Many pruritogenic mediators, including nerve growth factor, interleukin (IL)-31, thymic stromal lymphopoietin, and endothelin-1, are implicated in ...
Weilong Zhong, Xia Wu, Wei Zhang, Jie Zhang, Xiaofan Chen, Shihong Chen, Haiyan Huang, Yong Yang, Bo Yu, Xia Dou   +9 more
doaj   +1 more source

Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension

Frontiers in Immunology, 2022
IntroductionInflammation is a major pathological feature of pulmonary arterial hypertension (PAH), particularly in the context of inflammatory conditions such as systemic sclerosis (SSc).
Christoph Tabeling, Christoph Tabeling, Christoph Tabeling, Carla R. González Calera, Jasmin Lienau, Jakob Höppner, Thomas Tschernig, Olivia Kershaw, Birgitt Gutbier, Jan Naujoks, Julia Herbert, Bastian Opitz, Achim D. Gruber, Berthold Hocher, Berthold Hocher, Berthold Hocher, Norbert Suttorp, Norbert Suttorp, Harald Heidecke, Gerd-R. Burmester, Gabriela Riemekasten, Elise Siegert, Elise Siegert, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Martin Witzenrath, Martin Witzenrath, Martin Witzenrath   +30 more
doaj   +1 more source

Immunohistochemical Localization of Endothelin- 1 and Endothelin A Receptor in Human Primary Tooth Enamel Organ [PDF]

Journal of Dentistry, 2023
Statement of the Problem: Enamel organ (EO) is an ectodermal derived structure, which is involved in the different aspects of tooth development. Tooth development shares the same regulatory molecules and genes expressed in other developing organs ...
Soussan Irani, Shohreh Alimohammadi, Tahmineh Najafian   +2 more
doaj   +1 more source

Examining the role of insulin in the regulation of cardiovascular health [PDF]

, 2013
A substantial body of evidence has reported that insulin has direct actions on the cardiovascular system independent of its systemic effects on plasma glucose or lipids.
Salt, Ian P.
core   +1 more source

Ambrisentan, a Non‐peptide Endothelin Receptor Antagonist [PDF]

Cardiovascular Drug Reviews, 2006
ABSTRACTIncreasing numbers of experimental investigations and recently also of clinical trials strongly suggest an integral involvement of the endothelin (ET)‐system in the pathophysiology of a variety of disease states, mainly of the cardiovascular system.
Hartmut, Vatter, Volker, Seifert
openaire   +2 more sources

Cryo-EM structure of the endothelin-1-ETB-Gi complex

eLife, 2023
The endothelin ETB receptor is a promiscuous G-protein coupled receptor that is activated by vasoactive peptide endothelins. ETB signaling induces reactive astrocytes in the brain and vasorelaxation in vascular smooth muscle.
Fumiya K Sano, Hiroaki Akasaka, Wataru Shihoya, Osamu Nureki   +3 more
doaj   +1 more source

Bosentan for digital ulcers prevention does not worsen cardiopulmonary exercise test parameters in SSc patients with interstitial lung disease [PDF]

, 2016
Bosentan for digital ulcers prevention does not worsen cardiopulmonary exercise test parameters in SSc patients with interstitial lung ...
Amoroso, Daria, Barbano, Biagio, DI PAOLO, Marcello, Gigante, Antonietta, Palange, Paolo, Romaniello, Antonella, Rosato, Edoardo, Tallerini, Gaia   +7 more
core   +1 more source

Selective Endothelin-A Versus Combined Endothelin-A/Endothelin-B Receptor Blockade in Rat Chronic Heart Failure [PDF]

Circulation, 2000
Background—The relative efficacy of endothelin-A (ETA) receptor blockade versus combined ETA-ETBreceptor blockade in chronic heart failure (CHF) is still largely unknown.Methods and Results—We compared, in a rat model of CHF (coronary ligation), the hemodynamic and structural effects of 1 month of treatment with the ETAantagonist ABT-627 (5 mg · kg−1 ...
P, Mulder, H, Boujedaini, V, Richard, G, Derumeaux, J P, Henry, S, Renet, J, Wessale, T, Opgenorth, C, Thuillez   +8 more
openaire   +2 more sources