Results 31 to 40 of about 44,776 (142)

Endothelin-1 Drives Epithelial-Mesenchymal Transition In Hypertensive Nephroangiosclerosis [PDF]

, 2016
BACKGROUND: Tubulointerstitial fibrosis, the final outcome of most kidney diseases, involves activation of epithelial mesenchymal transition (EMT). Endothelin‐1 (ET‐1) activates EMT in cancer cells, but it is not known whether it drives EMT in the kidney.
Belloni, Anna S, Buccella, Valentina, CALO', LORENZO, Caroccia, Brasilina, Gioco, Francesca, Guerzoni, Eugenia, GUIDOLIN, DIEGO, Montini, Barbara, Pagnin, Elisa, Petrelli, Lucia, Piazza, Maria, Ravarotto, Verdiana, ROSSI, GIANPAOLO, SECCIA, TERESA MARIA   +13 more
core   +1 more source

Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension

Frontiers in Immunology, 2022
IntroductionInflammation is a major pathological feature of pulmonary arterial hypertension (PAH), particularly in the context of inflammatory conditions such as systemic sclerosis (SSc).
Christoph Tabeling, Christoph Tabeling, Christoph Tabeling, Carla R. González Calera, Jasmin Lienau, Jakob Höppner, Thomas Tschernig, Olivia Kershaw, Birgitt Gutbier, Jan Naujoks, Julia Herbert, Bastian Opitz, Achim D. Gruber, Berthold Hocher, Berthold Hocher, Berthold Hocher, Norbert Suttorp, Norbert Suttorp, Harald Heidecke, Gerd-R. Burmester, Gabriela Riemekasten, Elise Siegert, Elise Siegert, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Wolfgang M. Kuebler, Martin Witzenrath, Martin Witzenrath, Martin Witzenrath   +30 more
doaj   +1 more source

Endothelin and endothelin receptors in the renal and cardiovascular systems

Life Sciences, 2012
Endothelin-1 (ET-1) is a multifunctional hormone which regulates the physiology of the cardiovascular and renal systems. ET-1 modulates cardiac contractility, systemic and renal vascular resistance, salt and water renal reabsorption, and glomerular function.
Susi Heiden, Noriaki Emoto, Noriaki Emoto, Nicolas Vignon-Zellweger, Takashi Miyauchi   +4 more
openaire   +3 more sources

Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor [PDF]

, 2008
Background: Endothelin receptor antagonists inhibit the progression of many cancers, but research into their influence on glioma has been limited. Methods: We treated glioma cell lines, LN-229 and SW1088, and melanoma cell lines, A375 and WM35 ...
A Bagnato, A Bagnato, AV Budanov, D Salani, ER Levin, F Spinella, G Egidy, G Pan, H Peeters, H Walczak, HT Adler, J Eberle, J Nelson, JB Nelson, JD Stiles, Jennifer P Montgomery, JP Sheridan, JR Wu-Wong, K Ishikawa, K Kikuchi, K Takahashi, L Rosano, L Rosano, M Matsumoto, M Nagane, M Sone, M Takekawa, MC Hollander, N Kitagawa, Paul H Patterson, Q Zhan, Q Zhan, R Lahav, R Lahav, S He, S Jin, S Jin, S Velasco-Miguel, SP Harland, U Pagotto, V Naidoo, XW Wang, Y Berger   +42 more
core   +3 more sources

Endothelin-1 Predicts Hemodynamically Assessed Pulmonary Arterial Hypertension in HIV Infection. [PDF]

, 2016
BackgroundHIV infection is an independent risk factor for PAH, but the underlying pathogenesis remains unclear. ET-1 is a robust vasoconstrictor and key mediator of pulmonary vascular homeostasis.
AH Chester, Amanda S. Heringer, B Degano, B Degano, BJ Kircher, C Rubens, D Iglesias, D Shao, DB Badesch, F Bohm, F Leyva, G Barbaro, G Zou, GD Kanmogne, H Ehrenreich, H Nunes, James West, JD Rich, Jeffrey N. Martin, John S. Macgregor, LJ Rubin, M Berger, M Nootens, M Opravil, M Opravil, M Yoshibayashi, MQ Feijoo, MR Fisher, MT Gladwin, N Galie, N Galie, O Sitbon, O Sitbon, Peter Ganz, Priscilla Y. Hsue, PY Hsue, R Tibshirani, Rebecca Scherzer, RJ Oudiz, RN Channick, RN Channick, Rushi V. Parikh, RV Parikh, RV Parikh, S Almodovar, S Almodovar, S Shapiro, Steven G. Deeks, T Thenappan, VN Selby, VV McLaughlin, Yifei Ma   +51 more
core   +8 more sources

Protein kinase C inhibition attenuates vascular ET_B receptor upregulation and decreases brain damage after cerebral ischemia in rat

BMC Neuroscience, 2007
Background Protein kinase C (PKC) is known to be involved in the pathophysiology of experimental cerebral ischemia. We have previously shown that after transient middle cerebral artery occlusion, there is an upregulation of endothelin receptors in the ...
Vikman Petter, Stenman Emelie, Henriksson Marie, Edvinsson Lars   +3 more
doaj   +1 more source

Attenuation of ischemic liver injury by monoclonal anti-endothelin antibody, awETN40 [PDF]

, 1997
Background: Enhanced production of endothelin-1 (ET1), vasoconstrictive 21 amino acids produced by endothelial cells during ischemia and after reperfusion of the liver, is known to cause sinusoidal constriction and microcirculatory disturbances, which ...
Ishizaki, N, Jin, MB, Lee, R, Shimamura, T, Starzl, TE, Subbotin, V, Todo, S, Totsuka, E, Urakami, A, Zhang, S, Zhu, Y   +10 more
core   +1 more source

Cryo-EM structure of the endothelin-1-ETB-Gi complex

eLife, 2023
The endothelin ETB receptor is a promiscuous G-protein coupled receptor that is activated by vasoactive peptide endothelins. ETB signaling induces reactive astrocytes in the brain and vasorelaxation in vascular smooth muscle.
Fumiya K Sano, Hiroaki Akasaka, Wataru Shihoya, Osamu Nureki   +3 more
doaj   +1 more source

Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications [PDF]

, 2016
Aging is the primary risk factor underlying hypertension and incident cardiovascular disease. With aging, the vasculature undergoes structural and functional changes characterized by endothelial dysfunction, wall thickening, reduced distensibility, and ...
Harvey, Adam, Lopes, Rheure Alves, Montezano, Augusto C., Rios, Francisco, Touyz, Rhian   +4 more
core   +1 more source

Nuclear β-arrestin1 is a critical cofactor of hypoxia-inducible factor-1α signaling in endothelin-1-induced ovarian tumor progression [PDF]

, 2016
Hypoxia-inducible factor-1α (HIF-1α) mediates the response to hypoxia or other stimuli, such as growth factors, including endothelin-1 (ET-1), to promote malignant progression in numerous tumors.
Bagnato, Anna, Caprara, Valentina, CIANFROCCA, Roberta, Di Castro, Valeriana, Rosanò, Laura, Sestito, Rosanna, TOCCI, PIERA   +6 more
core   +1 more source