Results 131 to 140 of about 66,098 (241)

Correlation of erbB-2 gene amplification with low levels of estrogen and/or progesterone receptors in primary breast cancer : do erbB-2 products delineate hormone-independent tumors?

Biomedicine & Pharmacotherapy, 1989
We analyzed erbB-2 gene amplification in 170 primary breast carcinomas. Thirty-one percent of tumors exhibited additional copies of erbB-2 gene. Chi-square analysis did not elicit any association between gene amplification and either menopausal or node status. A slight trend was observed with respect to the SBR grading.
Roux-Dosseto, M., Romain, S., Dussault, N., Martin, P.M.   +3 more
openaire   +3 more sources

Transcriptomic and Neuroimaging Decoding of Brain‐Immune Crosstalk in Thyroid Eye Disease

Advanced Science, Volume 13, Issue 27, 13 May 2026.
This study employed an imaging transcriptomics framework integrating resting‐state fMRI with Allen Human Brain Atlas transcriptomic data, coupled with peripheral blood RNA sequencing, to decode brain‐immune crosstalk in thyroid eye disease. Frontal, parietal, subcortical, and brainstem regions were identified as key neuroimmune‐ vulnerable regions ...
Haiyang Zhang, Yuting Liu, Shufan Jiang, Zilin Fang, Mengda Jiang, Xiaofeng Tao, Tianyi Zhu, Jipeng Li, Sijie Fang, Xuefei Song, Yinwei Li, Jing Sun, Chuanjun Tong, Zhengrun Gao, Huifang Zhou, Xianqun Fan   +15 more
wiley   +1 more source

NAD+‒circadian rhythm coupling in dementia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang, Jiyeon Lee, Jun‐ping Pan, Rune Enger, Harald Hrubos‐Strøm, Erik S. Musiek, Evandro Fei Fang, Weidong Le   +7 more
wiley   +1 more source

Associations between pathologic tumor features and preadjuvant therapy cognitive performance in women diagnosed with breast cancer

Cancer Medicine, 2017
Intertumor heterogeneity has been proposed as a potential mechanism to account for variability in cognitive performance in women diagnosed with breast cancer.
Theresa A. Koleck, Catherine M. Bender, Susan M. Sereika, Christopher M. Ryan, Puja Ghotkar, Adam M. Brufsky, Rachel C. Jankowitz, Priscilla F. McAuliffe, Beth Z. Clark, Yvette P. Conley   +9 more
doaj   +1 more source

Extracellular portions of EGF receptor with TGFa and ErbB-2 [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2002
T. P. J. Garrett, M. Z. Lou, N. M. McKern, T. E. Adams, G. O. Lovrecz, R. N. Jorissen, E. C. Nice, A. W. Burgess, C. W. Ward   +8 more
openaire   +1 more source

Saikosaponin A Inhibits Migration/Invasion and Triggers Cell‐Cycle Arrest and Autophagy‐Induced Cell Death in HCT116 Cells and In Vivo

Food Frontiers, Volume 7, Issue 3, May 2026.
Saikosaponin A from Radix Bupleuri inhibited colorectal cancer HCT116 cells with low toxicity. SSA induced S/G2‐M cell cycle arrest and triggered autophagy via mTOR inhibition. SSA suppressed metastasis by blocking PI3K/AKT signaling pathway. SSA significantly reduced tumor growth without apparent toxicity.
Xiu‐Xiu Zhang, Wang‐Wei Zhang, Run‐Hui Ma, Zhi‐Jing Ni, Kiran Thakur, Mohammad Rizwan Khan, Jian‐Guo Zhang, Zhao‐Jun Wei   +7 more
wiley   +1 more source

Analysis of Somatic Mutations and Immunotherapy Biomarkers in Chinese Patients With Non‐Small Cell Lung Cancer During 2019–2024: A Retrospective Study

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Understanding genetic alterations in lung cancer remains challenging due to tumor heterogeneity and malignancy. This study aimed to investigate somatic variations and immune‐related biomarkers in Chinese patients with NSCLC.
Xiumei Liu, Weigong Chen, Chengqi Xin, Zexu Wang, Kaiyu Yi, Liang Wang, Jing Liu   +6 more
wiley   +1 more source

Molecular portrait-based correlation between primary canine mammary tumor and its lymph node metastasis: possible prognostic-predictive models and/or stronghold for specific treatments?

BMC Veterinary Research, 2012
Background This study aimed to evaluate the relationship between the molecular phenotype of the primary mammary tumor and its related lymph node metastasis in the dog to develop prognostic-predictive models and targeted therapeutic options.
Beha Germana, Brunetti Barbara, Asproni Pietro, Muscatello Luisa, Millanta Francesca, Poli Alessandro, Sarli Giuseppe, Benazzi Cinzia   +7 more
doaj   +1 more source

Viral Mechanisms and Drug Influences on Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) Pathway in Human Coronaviruses Infection: A Systematic Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aim Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway is crucial for various stages of immunity, from innate to adaptive responses. Type 1 IFNs activate JAK/STAT pathway by binding to receptors on JAK, phosphorylating STAT and upregulating interferon‐stimulated genes (ISGs) leading to cytokines ...
Esimebia Adjovi Amegashie, Ruth Oyawole Sikeola, Caleb Koranteng Kwayisi‐Darkwah, Gabriel Atampugbire, Emmanuel Ayitey Tagoe, Elijah Paintsil, Kwasi Torpey, Osbourne Quaye   +7 more
wiley   +1 more source

SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis

EMBO Molecular Medicine, 2012
Loss of SPRY2 and activation of receptor tyrosine kinases are common events in prostate cancer (PC). However, the molecular basis of their interaction and clinical impact remains to be fully examined.
Meiling Gao, Rachana Patel, Imran Ahmad, Janis Fleming, Joanne Edwards, Stuart McCracken, Kanagasabai Sahadevan, Morag Seywright, Jim Norman, Owen Sansom, Hing Y. Leung   +10 more
doaj   +1 more source