Results 91 to 100 of about 71,317 (233)
Pituitary gigantism due to a novel AIP germline splice-site variant
Pituitary gigantism is a rare pediatric disorder caused by excess growth hormone (GH) secretion. In almost 50% of cases, a genetic cause can be identified, with pathogenic variants in the aryl hydrocarbon receptor-interacting protein (AIP) gene being the
Elisa Lamback+6 more
doaj +1 more source
Pss knockdown in the midgut causes growth retardation in Drosophila similar to that in human LMHD
Abstract Background Phosphatidylserine synthase (PSS), localized in the mitochondrial membrane, synthesizes phosphatidylserine. In humans, mutations in Pss lead to Lenz–Majewski hyperostotic dwarfism, a disorder affecting growth and development. The effects of Pss mutations on the growth of Drosophila melanogaster are not fully known. Hence, this study
Kwan‐Young Kim+4 more
wiley +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang+7 more
wiley +1 more source
PPAR-γ Agonists and Their Effects on IGF-I Receptor Signaling: Implications for Cancer
It is now well established that the development and progression of a variety of human malignancies are associated with dysregulated activity of the insulin-like growth factor (IGF) system. In this regard, promising drugs have been developed to target the
A. Belfiore, M. Genua, R. Malaguarnera
doaj +1 more source
New insights into epileptic spasm generation and treatment from the TTX animal model
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann+2 more
wiley +1 more source
ABSTRACT Background and objective Anorexia nervosa (AN) is a mental disorder most prevalent among adolescent females, with rising cases in younger and more culturally diverse populations. Unhealthy activity patterns are common and have been linked to increased relapse rates; however, data on objectively measured physical activity levels (PALs) in this ...
Álex V. Pagador+4 more
wiley +1 more source
How a Mutation that Slows Aging Can Also Disproportionately Extend End-of-Life Decrepitude
Summary: The goal of aging research is to extend healthy, active life. For decades, C. elegans daf-2 insulin/insulin-like growth factor 1 (IGF-1) receptor mutants have served as a model for extended lifespan and youthfulness.
Katie Podshivalova+2 more
doaj
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers+10 more
wiley +1 more source
The impact of the IGF-1 system of cancer cells on radiation response â An in vitro study
Background: Overexpression of the insulin-like growth factor-1 receptor (IGF-1R) is associated with increased cell proliferation, differentiation, transformation, and tumorigenicity.
Senthiladipan Venkatachalam+5 more
doaj
Obesity is a global health problem that requires research and regulatory attention. This research aims to investigate transcriptome‐wide changes induced by Vigna umbellata (Tsuruazuki) using a stem cell‐based tool and preadipocytes to explore its untapped potential as a functional food for anti‐obesity applications.
Elda Nurafnie Ibnu Rasid+6 more
wiley +1 more source