Results 71 to 80 of about 156,266 (290)

Obesity and cancer: existing and new hypotheses for a causal connection [PDF]

, 2018
Existing explanations of obesity-associated cancer emphasise direct mutagenic effects of dietary components or hormonal imbalance. Some of these hypotheses are reviewed briefly, but recent evidence suggests a major role for chronic inflammation in cancer
Darlington, L. Gail, McPherson, Megan, Stone, Trevor W.   +2 more
core   +2 more sources

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Growth Hormone-Releaser Diet Attenuates Cognitive Dysfunction in Klotho Mutant Mice via Insulin-Like Growth Factor-1 Receptor Activation in a Genetic Aging Model [PDF]

Endocrinology and Metabolism, 2014
BackgroundIt has been recognized that a defect in klotho gene expression accelerates the degeneration of multiple age-sensitive traits. Accumulating evidence indicates that aging is associated with declines in cognitive function and the activity of ...
Seok Joo Park, Yoon Hee Chung, Jeong Hyun Lee, Duy-Khanh Dang, Yunsung Nam, Ji Hoon Jeong, Yong Sun Kim, Toshitaka Nabeshima, Eun-Joo Shin, Hyoung-Chun Kim   +9 more
doaj   +1 more source

Gene polymorphisms in primary biliary cirrhosis: association with the disease and hepatic osteopathy [PDF]

, 2007
Genetic factors have been implicated in the pathogenesis of osteoporosis, a common disorder in primary biliary cirrhosis (PBC). Estrogen receptor-alpha gene (ER- ), vitamin-D-receptor gene (VDR) and IL-1-receptor-antagonist gene (IL-1RN) are all ...
Bajnok, Éva, Ferenci, Péter, Lakatos, Péter, Lakatos, Péter László, Szalay, Ferenc, Takács, István, Willheim-Polli, Claudia   +6 more
core  

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

The Role of Insulin, Insulin Growth Factor, and Insulin-Degrading Enzyme in Brain Aging and Alzheimer's Disease

Neural Plasticity, 2005
Most brain insulin comes from the pancreas and is taken up by the brain by what appears to be a receptor-based carrier. Type 2 diabetes animal models associated with insulin resistance show reduced insulin brain uptake and content.
Claude Messier, Kevin Teutenberg
doaj   +1 more source

Blockade of the type I IGF receptor expression in human prostate cancer cells inhibits proliferation and invasion, up‐regulates IGF binding protein‐3, and suppresses MMP‐2 expression

The Journal of Pathology, 2003
AbstractThe type I insulin‐like growth factor receptor (IGF‐IR) is involved in tumour cell proliferation, invasion, and cancer cell survival. Several studies indicate that the IGF axis contributes to prostate cancer pathogenesis, but there is no consensus regarding the relative expression of the IGF‐IR in benign and malignant prostate epithelium.
Grzmil, M., Hemmerlein, Bernhard, Thelen, Paul, Schweyer, Stefan, Burfeind, Peter   +4 more
openaire   +3 more sources

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507). [PDF]

PLoS ONE, 2009
The IGF receptor type 1 (IGF-1R) pathway is frequently deregulated in human tumors and has become a target of interest for anti-cancer therapy.We used a panel of 22 non-small cell lung cancer (NSCLC) cell lines to investigate predictive biomarkers of ...
Yixuan Gong, Evelyn Yao, Ronglai Shen, Aviva Goel, Maria Arcila, Julie Teruya-Feldstein, Maureen F Zakowski, Stanley Frankel, Martin Peifer, Roman K Thomas, Marc Ladanyi, William Pao   +11 more
doaj   +1 more source

Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer. [PDF]

, 2018
Ovarian cancer (OC) is most lethal malignancy among all gynecological cancer. Large bodies of evidences suggest that mitochondrial-derived ROS play a critical role in the development and progression of OC.
Devarajan, Asokan, Farias-Eisner, Gina, Farias-Eisner, Robin, Fogelman, Alan M, Gao, Feng, Grijalva, Victor, Nwokedi, Josephine, Reddy, Srinivasa T, Su, Feng, Trost, Hannah, Yalamanchi, Ashna, Yalamanchi, Meghna   +11 more
core   +3 more sources