Results 51 to 60 of about 156,266 (290)
IGF-1 protects against angiotensin II-induced cardiac fibrosis by targeting αSMA
Cell Death and Disease, 2021 The insulin-like growth factor 1 receptor (IGF-1R) signaling in cardiomyocytes is implicated in physiological hypertrophy and myocardial aging. Although fibroblasts account for a small amount of the heart, they are activated when the heart is damaged to ...
Sangmi Ock +5 more
doaj +1 more source
Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer. [PDF]
, 2017 Breast cancer remains the leading cause of cancer death in women owing to metastasis and the development of resistance to established therapies. Macrophages are the most abundant immune cells in the breast tumor microenvironment and can both inhibit and ...
A Fantozzi +66 more
core +2 more sources
Respiratory Research, 2005 Background Cellular responses to aging and oxidative stress are regulated by type 1 insulin-like growth factor receptor (IGF-1R). Oxidant injury, which is implicated in the pathophysiology of a number of respiratory diseases, acutely upregulates IGF-1R ...
Flejou Jean-François +7 more
doaj +1 more source
Understanding the key to targeting the IGF axis in cancer: a biomarker assessment
Frontiers in Oncology, 2015 Type 1 insulin like growth factor receptor (IGF-1R) targeted therapies showed compelling pre-clinical evidence; however, to date, this failed to translate to patient benefit in Phase 2/3 trails in unselected patients. This was further complicated by the
Kunal Amratlal Lodhia +2 more
doaj +1 more source
FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism [PDF]
, 2019 A major target of insulin signaling is the FoxO family of Forkhead transcription factors, which translocate from the nucleus to the cytoplasm following insulin-stimulated phosphorylation.
Albrechtsen, N. +15 more
core +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Breast Cancer Research, 2018 Background Early analyses of human breast cancer identified high expression of the insulin-like growth factor type 1 receptor (IGF-1R) correlated with hormone receptor positive breast cancer and associated with a favorable prognosis, whereas low ...
Alison E. Obr +9 more
doaj +1 more source
DAF-16/FoxO in Caenorhabditis elegans and its role in metabolic remodeling [PDF]
, 2020 DAF-16, the only forkhead box transcription factors class O (FoxO) homolog in Caenorhabditis elegans, integrates signals from upstream pathways to elicit transcriptional changes in many genes involved in aging, development, stress, metabolism, and ...
Braeckman, Bart, Zečić, Aleksandra
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice. [PDF]
PLoS ONE, 2014 Insulin-like growth factor-I (IGF-I) deficiency causes growth delay, and IGF-I has been shown to partially mediate bone anabolism by parathyroid hormone (PTH). PTH-related protein (PTHrP) is abundant in bone, and has osteogenic features by poorly defined
Lourdes Rodríguez-de la Rosa +7 more
doaj +1 more source