Results 31 to 40 of about 156,266 (290)
PLoS ONE, 2019 Stress-induced cardiac hypertrophy leads to heart failure. Our previous studies demonstrate that insulin-like growth factor-II receptor (IGF-IIR) signaling is pivotal to hypertrophy regulation.
Ruey-Lin Chang +9 more
doaj +1 more source
Insulin signaling regulates mitochondrial function in pancreatic beta-cells. [PDF]
PLoS ONE, 2009 Insulin/IGF-I signaling regulates the metabolism of most mammalian tissues including pancreatic islets. To dissect the mechanisms linking insulin signaling with mitochondrial function, we first identified a mitochondria-tethering complex in beta-cells ...
Siming Liu +8 more
doaj +1 more source
Germline PTPRD mutations in Ewing sarcoma: biologic and clinical implications. [PDF]
, 2013 Ewing sarcoma occurs in children, adolescents and young adults. High STAT3 levels have been reported in approximately 50% of patients with Ewing sarcoma, and may be important in tumorigenesis.
Anderson, Peter M +9 more
core +3 more sources
PLoS ONE, 2016 Therapies targeting the type I insulin-like growth factor receptor (IGF-1R) have not been developed with predictive biomarkers to identify tumors with receptor activation.
Marc A Becker +10 more
doaj +1 more source
Olmesartan potentiates the anti-angiogenic effect of sorafenib in mice bearing Ehrlich's ascites carcinoma: role of angiotensin (1-7). [PDF]
PLoS ONE, 2014 Local renin-angiotensin systems exist in various malignant tumor tissues; this suggests that the main effector peptide, angiotensin II, could act as a key factor in tumor growth.
Mohammad M Abd-Alhaseeb +3 more
doaj +1 more source
Biochemical and Biophysical Research Communications, 1986 18,54-SF cells, which secrete rat insulin-like growth factor II (rIGF-II), have abundant type 2 IGF receptors. We have purified the type 2 receptor from these cells by solubilization of crude membranes in Triton X-100, followed by chromatography on agarose-immobilized rIGF-II.
R G, Rosenfeld +4 more
openaire +2 more sources
Angiotensin II receptor blocker attenuates intrarenal renin-angiotensin-system and podocyte injury in rats with myocardial infarction. [PDF]
PLoS ONE, 2013 The mechanisms and mediators underlying common renal impairment after myocardial infarction (MI) are still poorly understood. The present study aimed to test the hypothesis that angiotensin II type 1 receptor blockers (ARBs) provides renoprotective ...
Zhu-zhi Wen +7 more
doaj +1 more source
Decreased IGF Type 1 Receptor Signaling in Mammary Epithelium during Pregnancy Leads to Reduced Proliferation, Alveolar Differentiation, and Expression of Insulin Receptor Substrate (IRS)-1 and IRS-2 [PDF]
Endocrinology, 2011 The IGFs and the IGF type 1 receptor (IGF-1R) are essential mediators of normal mammary gland development in mice. IGF-I and the IGF-1R have demonstrated functions in formation and proliferation of terminal end buds and in ductal outgrowth and branching during puberty.
Zhaoyu, Sun +3 more
openaire +2 more sources
PLOS ONE, 2022 Background and aims So far, few clinical trials are available concerning the role of growth hormone receptor (GHR)/signal transducer and activator of transcription 5 (STAT5)/insulin like growth factor-1 (IGF-1) axis in hepatocarcinogenesis. The aim of this study was to evaluate the hepatic expression of GHR/STAT5/IGF-1 signaling pathway in ...
Mona A. Abu El-Makarem +9 more
openaire +2 more sources
Journal of Neuroinflammation, 2011 Background Insulin-like growth factor-I (IGF-I) exerts neuroprotective actions in the central nervous system that are mediated at least in part by control of activation of astrocytes. In this study we have assessed the efficacy of exogenous IGF-I and IGF-
Goya Rodolfo G +3 more
doaj +1 more source