Results 11 to 20 of about 156,266 (290)

The Continuing Evolution of Insulin-like Growth Factor Signaling [version 1; peer review: 4 approved]

F1000Research, 2020
The insulin-like growth factors (IGFs; IGF1/IGF2), known for their regulation of cell and organismal growth and development, are evolutionarily conserved ligands with equivalent peptides present in flies (D. melanogaster), worms (C. elegans) among others.
Steven A Rosenzweig
doaj   +1 more source

Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice [PDF]

, 2012
We recently demonstrated that reducing IGF-1 receptor (IGF-1R) numbers in the endothelium enhances nitric oxide (NO) bioavailability and endothelial cell insulin sensitivity.
A. Abbas, A. Skromna, Booth, Bredt, Chen, Cubbon, D. J. Beech, De Meyts, Federici, Fulton, Gatenby, GUILLOT, H. Imrie, H. Viswambharan, J. Smith, Jiang, K. M. Channon, Kubota, Li, M. Gage, M. T. Kearney, N. Yuldasheva, Nakagawa, P. J. Grant, P. Sukumar, R. M. Cubbon, Razani, S. B. Wheatcroft, S. Galloway, S. T. Rashid, S. Xuan, Schleicher, Stegmayr, T. S. Futers, V. K. Gatenby, Vicent, Wheatcroft   +36 more
core   +1 more source

Reversal of age-related learning deficiency by the vertebrate PACAP and IGF-1 in a novel invertebrate model of aging: the pond snail (Lymnaea Stagnalis) [PDF]

, 2014
With the increase of life span, nonpathological age-related memory decline is affecting an increasing number of people. However, there is evidence that age-associated memory impairment only suspends, rather than irreversibly extinguishes, the intrinsic ...
Alexander, Audesirk, Chaudhury, D. Regl di, Delcourt, Du, G. Kemenes, Hattiangady, Hermann, Hernadi, I. Kemenes, J  zsa, Kemenes, Kemenes, Lee, Markowska, Otto, Otto, Patel, Patel, Pavlopoulos, Pirger, Pirger, Pirger, Roberto, S. Naskar, Sacchetti, Shioda, Silhol, Tamas, Telegdy, Vaudry, Watson, Watson, Yang, Yeoman, Z. Laszlo, Z. Pirger, Zhang   +38 more
core   +2 more sources

Differential Expression of IGF Components and Insulin Receptor Isoforms in Human Seminoma Versus Normal Testicular Tissue

Neoplasia: An International Journal for Oncology Research, 2005
Insulin-like growth factors (IGF) have mitogenic and antiapoptotic functions, and may be involved in tumor growth. The purpose of the study was to investigate the role of IGF components in seminoma compared to normal testis.
Tanja Pascale Neuvians, Isabella Gashaw, Andrea Hasenfus, Axel Häcker, Elke Winterhager, Rainer Grobholz   +5 more
doaj   +1 more source

The mechanism of action of the histone deacetylase inhibitor vorinostat involves interaction with the insulin-like growth factor signaling pathway. [PDF]

PLoS ONE, 2011
A correlation between components of the insulin-like growth factor (IGF) system and endometrial cancer risk has been shown in recent studies. The antitumor action of vorinostat, a histone deacetylase inhibitor, involves changes in the expression of ...
Rive Sarfstein, Ilan Bruchim, Ami Fishman, Haim Werner   +3 more
doaj   +1 more source

Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy [PDF]

, 1992
The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor has been detected in many cells and tissues. In the rat, there is a dramatic developmental regulation of IGF-II/M6P receptor expression, the receptor being high in fetal and ...
Eisenmenger, Wolfgang, Funk, B., Hansmann, A., Kessler, U., Kiess, W., Kolb, H. J.   +5 more
core   +1 more source

Structural Analogs of Human Insulin-like Growth Factor (IGF) I with Altered Affinity for Type 2 IGF Receptors

Journal of Biological Chemistry, 1989
We have used site-directed mutagenesis of a synthetic gene for insulin-like growth factor (IGF) I to prepare three analogs in which specific residues in the A region are replaced with the corresponding residues in the A chain of insulin. The analogs are [Ile41, Glu45, Gln46, Thr49, Ser50, Ile51, Ser53, Tyr55, Gln56]IGF I (A chain mutant), in which ...
M A, Cascieri, G G, Chicchi, J, Applebaum, B G, Green, N S, Hayes, M L, Bayne   +5 more
openaire   +2 more sources

Systematic Survey of the Role of IGF in the Link Between Diabetes and Cancer [PDF]

, 2018
Epidemiological studies have proposed a link between type II diabetes and cancer via the IGF/insulin signaling pathway, which includes insulin-like peptides (IGF1, IGF2, and insulin), insulin receptors (IR-A, IR-B, IGF1R, and hybrids), and insulin ...
Devanathan, Nirupama, Kimble-Hill, Ann C.   +1 more
core   +2 more sources

Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling. [PDF]

, 2016
The tumor microenvironment (TME) exerts critical pro-tumorigenic effects through cytokines and growth factors that support cancer cell proliferation, survival, motility and invasion.
Flashner-Abramson, E, Karin, M, Levitzki, A, Sanchez-Lopez, E, Shalapour, S, Taniguchi, K, Zhong, Z   +6 more
core   +1 more source

Correlation of serum IGF-1, AGEs and their receptors with the risk of colorectal cancer in patients with type 2 diabetes mellitus

Frontiers in Oncology, 2023
BackgroundAccording to epidemiological evidence, people with type 2 diabetes mellitus have a higher risk of developing colorectal cancer.ObjectiveTo examine the relationship between colorectal cancer (CRC) and serum levels of IGF-1, IGF-1R, AGEs,RAGE and sRAGE in patients with type 2 diabetes.MethodsBy using RNA−Seq data of CRC patients from The Cancer
Zeng Chen, Qiao Hong
openaire   +3 more sources