Results 221 to 230 of about 71,317 (233)

Expression of Insulin-like Growth Factors (IGF)-1 and -2, IGF-binding Proteins-2 and -3, and Receptors for Growth Hormone, IGF Type-1 and -2 and Insulin in the Gastrointestinal Tract of Neonatal Calves

Growth Factors, 2004
Growth hormone (GH), insulin-like growth factors (IGFs) and insulin influence post-natal gastrointestinal development and function. We have measured by real-time PCR the mRNA levels of IGF-1 and -2, IGF-binding proteins (IGFBPs)-2 and -3, and receptors for GH, IGF type-1 and -2, and insulin in esophagus, rumen, fundus, pylorus, duodenum, jejunum, ileum
J.W. Blum, H.M. Hammon, Edgar Ontsouka
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Contribution of Residues A54 and L55 of the Human Insulin-like Growth Factor-II (IGF-II) A Domain to Type 2 IGF Receptor Binding Specificity

Growth Factors, 2001
The underlying specificity of the interaction between insulin-like growth factor-II (IGF-II) and mammalian Type 2 insulin-like growth factor/cation-independent mannose 6 phosphate receptor (IGF2R) is not understood. We have mutated residues A54 and L55 of IGF-II in the second A domain helix to arginine (found in the corresponding positions of IGF-I ...
Forbes, B., McNeil, K., Scott, C., Surinya, K., Cosgrove, L., Wallace, J.   +5 more
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Preferential binding of insulin‐like growth factor‐II (IGF‐II) to a putative α2β2 IGF‐II receptor type in C2 myoblasts

European Journal of Biochemistry, 1992
We have studied insulin‐like‐growth‐factor (IGF) binding in two subclones of the C2 myogenic cell line. In the permissive parental subclone, myoblasts differentiate spontaneously into myotubes in medium supplemented with fetal calf serum. Unlike permissive myoblasts, inducible myoblasts require high concentrations of insulin (1.6 μM) or lower ...
Domeyne, A., Pinset, C., Montarras, D., Garandel, V., Rosenfeld, R.G., Barenton, Bruno   +5 more
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Type-2 IGF Receptor: A Multi-Ligand Binding Protein

Hormone and Metabolic Research, 1999
The Type-2 insulin-like growth factor receptor (IGF2R) is a ubiquitously expressed integral glycoprotein with a molecular mass of 300 kDa. Four different classes of ligands are presently known, binding to distinct sites at the extracytoplasmic receptor domain: mannose 6-phosphate-containing lysosomal enzymes, the non-glycosylated IGF II, retinoic acid,
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Maternal Insulin-like Growth Factor-II Promotes Placental Functional Development Via the Type 2 IGF Receptor in the Guinea Pig

Placenta, 2008
In guinea pigs, maternal insulin-like growth factor (IGF) infusion in early-pregnancy enhances placental transport near-term, increasing fetal growth and survival. The effects of IGF-II, but not IGF-I, appear due to enhanced placental labyrinthine (exchange) development. To determine if the type-2 IGF receptor (IGF2R) mediates these distinct actions of
Sferruzzi-Perri, A., Owens, J., Standen, P., Roberts, C.   +3 more
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Insulin-like Growth Factor (IGF) I Down-Regulates Type 1 IGF Receptor (IGF 1R) and Reduces the IGF I Response in A549 Non-Small-Cell Lung Cancer and Saos-2/B-10 Osteoblastic Osteosarcoma Cells

Experimental Cell Research, 2001
The insulin-like growth factor type 1 receptor (IGF 1R) mediates the acute metabolic effects of IGF I as well as IGF I-stimulated cell proliferation and protection from apoptosis. IGF binding proteins (IGFBPs) can modulate these responses. We, therefore, investigated whether intrinsic IGFBPs interfere with IGF I-induced regulation of IGF 1R expression ...
Claudia Ghirlanda-Keller, Kaspar H. Winterhalter, Robert A. Olie, Christoph Schmid, Katalin Tisa Bostedt, Jürgen Zapf   +5 more
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Abstract 3277: Insulin-like growth factor-2 (IGF-2) circumvents the antiangiogenic activity of SCH717454, a human antibody that blocks ligand binding to the Type 1 insulin-like growth factor receptor (IGF-1R)

Cancer Research, 2011
Abstract Background. Deregulated insulin-like growth factor signaling through IGF-1R is common to many human cancers, including childhood solid tumors, and has become an important target for therapeutics development. We reported that there was a rapid decrease in tumor-associated VEGF in childhood sarcoma xenografts responding to an IGF ...
Peter J. Houghton, Doris A. Phelps, Hemant K. Bid   +2 more
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Type 2 IGF Receptor-Mediated Events

1999
In the insulin-like growth factor (IGF) field, receptors were identified by the classic approach of competitive binding and affinity crosslinking of radiolabeled IGF-I and IGF-II (1). A receptor that preferred IGF-I over IGF-II, bound insulin with low affinity, and had a binding subunit of approx 130 kDa became known as the IGF-I receptor or the type 1
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EFFECTS OF INSULIN‐LIKE GROWTH FACTOR‐BINDING PROTEIN 2 AND AN IGF‐TYPE I RECEPTOR‐BLOCKING ANTIBODY ON APOPTOSIS IN HUMAN TERATOCARCINOMA CELLS IN VITRO

Cell Biology International, 2001
Human teratocarcinoma cells (Tera‐2) deprived of serum undergo programmed cell death which can be counteracted by simultaneous addition of IGF‐I or IGF‐II. This protective effect of IGFs was specific in the sense that both addition of IGF‐binding protein‐2, and blocking of the IGF‐type I receptor by a specific antibody, both resulted in an increased ...
M. Granerus, Wilhelm Engström
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Increased tumorigenicity in the human pancreatic cell line MIA PaCa‐2 Is associated with an aberrant regulation of an IGF‐1 autocrine loop and lack of expression of the TGF‐β type RII receptor

Journal of Cellular Physiology, 1995
AbstractThe growth characteristics associated with tumorigenicity were determined in clones of MIA PaCa‐2 and PANC‐1 pancreatic carcinoma cells. MIA PaCa‐2 cells differed from PANC‐1 cells in that they rapidly formed tumors in nude mice, formed colonies more rapidly and formed larger colonies in soft agar, and were cloned more efficiently when seeded ...
James W. Freeman, William E. Strodel, Cynthia Mattingly   +2 more
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