Computational insights into the allosteric behavior of mini proinsulin driven by C peptide mobility [PDF]
Scientific ReportsThe production of recombinant insulin remains challenging, particularly in enhancing refolding efficiency and bioactivity. Mini-proinsulin analogs, which involve reducing the length of the C-peptide, offer potential improvements in insulin production ...
Esra Ayan
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Rapid insulin-dependent endocytosis of the insulin receptor by caveolae in primary adipocytes. [PDF]
PLoS ONE, 2009 BACKGROUND:The insulin receptor is localized in caveolae and is dependent on caveolae or cholesterol for signaling in adipocytes. When stimulated with insulin, the receptor is internalized.
Siri Fagerholm +4 more
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Insulin-Responsive Transcription Factors
Biomolecules, 2021 The hormone insulin executes its function via binding and activating of the insulin receptor, a receptor tyrosine kinase that is mainly expressed in skeletal muscle, adipocytes, liver, pancreatic β-cells, and in some areas of the central nervous system ...
Gerald Thiel +2 more
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Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues. [PDF]
PLoS ONE, 2012 BACKGROUND: Insulin analogues comprising acidic amino acid substitutions at position B10 have previously been shown to display increased mitogenic potencies compared to human insulin and the underlying molecular mechanisms have been subject to much ...
Tine Glendorf +7 more
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Far-western Blotting Detection of the Binding of Insulin Receptor Substrate to the Insulin Receptor
Bio-Protocol, 2023 Far-western blotting, derived from the western blot, has been used to detect interactions between proteins in vitro, such as receptor–ligand interactions.
Jinghua Peng +3 more
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Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system
The Journal of Headache and Pain, 2022 Background Clinical observations suggest that hyperinsulinemia and insulin resistance can be associated with migraine headache. In the present study we examined the effect of insulin on transient receptor potential vanilloid 1 (TRPV1) receptor-dependent ...
Judit Rosta +5 more
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ISOLATION AND CHARACTERIZATION OF INSULIN RECEPTOR OF PLASMA MEMBRANES OF RAT LIVER CELLS AT MODEL OF TYPE 2 DIABETES [PDF]
Biotechnologia Acta, 2014 The insulin receptor was isolated from the liver cell membranes of control and diabetic rats. The protein purity was controlled by electrophoresis and Western blot.
T. I. Halenova +3 more
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Protein kinase Cε modulates insulin receptor localization and trafficking in mouse embryonic fibroblasts. [PDF]
PLoS ONE, 2013 We have previously shown that deletion of protein kinase C epsilon (PKCε) in mice results in protection against glucose intolerance caused by a high fat diet.
David J Pedersen +3 more
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Engineering of insulin receptor isoform-selective insulin analogues. [PDF]
PLoS ONE, 2011 BACKGROUND: The insulin receptor (IR) exists in two isoforms, A and B, and the isoform expression pattern is tissue-specific. The C-terminus of the insulin B chain is important for receptor binding and has been shown to contact the IR just adjacent to ...
Tine Glendorf +5 more
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Onderstepoort Journal of Veterinary Research, 2013 The insulin-like growth factor system (insulin-like growth factor 1, insulin-like growth factor 2, insulin-like growth factor 1 receptor, insulin-like growth factor 2 receptor and six insulin-like growth factor-binding proteins) and insulin are essential
Stephen B. Hughes +3 more
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