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Insulin Receptors and Insulin Resistance
Annual Review of Medicine, 1983Resistance to the action of insulin plays a central role in many important disease states, including diabetes and obesity. Many insights into the mechanism and significance of insulin resistance in these and other disorders have followed upon our expanding knowledge regarding insulin receptors.
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Diabetes, 1972
Studies with bulky and insoluble insulin derivatives indicate that this hormone can activate various metabolic processes by interaction with cell surface structures. A definition of “receptor” is offered which is operationally useful in studies directed to the identification and purification of receptor structures.
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Studies with bulky and insoluble insulin derivatives indicate that this hormone can activate various metabolic processes by interaction with cell surface structures. A definition of “receptor” is offered which is operationally useful in studies directed to the identification and purification of receptor structures.
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Annales d'endocrinologie, 1996
The cloning of the insulin receptor not only established the primary structure of this membrane-bound glycoprotein but also offered the material necessary for the study of the molecular functions of this tyrosine-kinase receptor using molecular biology tools.
E, Clauser, C, Auzan, I, Leconte
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The cloning of the insulin receptor not only established the primary structure of this membrane-bound glycoprotein but also offered the material necessary for the study of the molecular functions of this tyrosine-kinase receptor using molecular biology tools.
E, Clauser, C, Auzan, I, Leconte
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Endocrine-Related Cancer, 2011
The widespread epidemic of obesity and type 2 diabetes has raised concern for the impact of these disorders as risk factors for cancer and has renewed the interest for studies regarding the involvement of hyperinsulinemia and insulin receptor (IR) in cancer progression.
Belfiore, Antonino +1 more
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The widespread epidemic of obesity and type 2 diabetes has raised concern for the impact of these disorders as risk factors for cancer and has renewed the interest for studies regarding the involvement of hyperinsulinemia and insulin receptor (IR) in cancer progression.
Belfiore, Antonino +1 more
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THE ERYTHROCYTE INSULIN RECEPTOR
Australian Journal of Experimental Biology and Medical Science, 1981SummaryA precise, reproducible radioreceptor assay has been developed for insulin receptors on human erythrocytes. The mean specific binding in 11 normal volunteers was 7.7% ± 1.6 (S.D.) per 2.25 × 109 erythrocytes. The intra and inter assay coefficients of variation are 4%.
A, McElduff, C J, Eastman
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Annual Review of Pharmacology and Toxicology, 1983
S, Jacobs, P, Cuatrecasas
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S, Jacobs, P, Cuatrecasas
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1983
Publisher Summary This chapter focuses on insulin receptors in brain. It has been demonstrated by two different means that insulin from blood can reach the cerebrospinal fluid and then, presumably, the central nervous system tissue. While the access of circulating insulin is quite limited by the presence of the blood–brain barrier, the non-barrier ...
J, Havrankova, J, Roth, M J, Brownstein
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Publisher Summary This chapter focuses on insulin receptors in brain. It has been demonstrated by two different means that insulin from blood can reach the cerebrospinal fluid and then, presumably, the central nervous system tissue. While the access of circulating insulin is quite limited by the presence of the blood–brain barrier, the non-barrier ...
J, Havrankova, J, Roth, M J, Brownstein
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Mechanisms controlling pancreatic islet cell function in insulin secretion
Nature Reviews Molecular Cell Biology, 2021Jonathan Campbell, Christopher B Newgard
exaly