Results 261 to 270 of about 681,804 (310)

Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles

Advanced Science, EarlyView.
Recent studies highlighted the heterogeneity of EVs and the influence of microenvironmental signals on their therapeutic efficacy. This review offers a comprehensive overview of strategies and mechanisms to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation.
Bilu Xiang, Shiying Zhang, Irene Shuping Zhao, Xueqi Gan, Yang Zhang   +4 more
wiley   +1 more source

Functional profiling of synthetic camel milk-derived peptides with implication in glucose transport and diabetes. [PDF]

PLoS One
Anwar I, Khan FB, Baby B, Antony P, Mudgil P, Gan CY, Maqsood S, Vijayan R, Muhammad K, Ayoub MA.   +9 more
europepmc   +1 more source

Isoproterenol modulates insulin activation of insulin receptor kinase in intact rat adipocytes [PDF]

, 1988
Klein, H. H., Matthaei, S., Scriba, Peter Christian   +2 more
core  

C1q+ Macrophage–Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
In the TME of NPC, C1q secreted by C1q+ TAMs interacted with GPR17 to activate PI3K/AKT signaling through strengthening GPR17 coupling PI3K and increasing calcium levels in tumor cells. The activated PI3K/AKT signaling further induces DNA hypermethylation to promote the malignancy and stemness of tumor cells.
Yunzhi Liu, Cuicui Huang, Min Luo, Wenfu Lu, Baifeng Zhang, Lu Bai, Shuyue Zheng, Yanan Tan, Shanshan Li, Huali Wang, Lanqi Gong, Xinyuan Guan   +11 more
wiley   +1 more source

Efficacy and hypoglycaemia outcomes with once-weekly insulin icodec versus once-daily basal insulin in type 2 diabetes according to baseline glucagon-like peptide-1 receptor agonist and sodium-glucose co-transporter-2 inhibitor use: A post hoc analysis of ONWARDS 1-5. [PDF]

Diabetes Obes Metab
Vilsbøll T, Fu A, Kellerer M, Kumar B, Søgaard SB, Goldenberg R.   +5 more
europepmc   +1 more source

The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression

Advanced Science, EarlyView.
LC‐GABA neurons exhibit elevated activity to noxious and aversive stimuli in chronic pain, and their activation alleviates pain‐ and depression‐like behaviors. While LC‐GABA neurons target LC‐NA neurons and GABA and Glu neurons in the vlPAG, they modulate the pain responses of LC‐NA neurons but regulate pain‐ and depression‐like behaviors through their
Yuan Gao, Xue Zhang, Xiao‐Juan Liu, Yi‐Ling Sun, Cui Yin, Dong‐Liang Tang, Cheng Xiao, Chunyi Zhou   +7 more
wiley   +1 more source

Unraveling the relationship between head circumference and MC4R deficiency from infancy to adulthood: a case-control study. [PDF]

Obesity (Silver Spring)
van der Walle EEPL, de Groot CJ, Kleinendorst L, de Klerk H, Welling MS, Abawi O, Meeusen REH, Boon MR, van Rossum EFC, van Haelst MM, van den Akker ELT.   +10 more
europepmc   +1 more source

Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism. [PDF]

PLoS One
Tsuneki H, Maeda T, Takatsuki M, Sekine T, Masui S, Onishi K, Takeda R, Sugiyama M, Sakurai T, Yanagisawa M, Wada T, Sasaoka T.   +11 more
europepmc   +1 more source

Paeoniflorin: a review of its pharmacology, pharmacokinetics and toxicity in diabetes. [PDF]

Front Pharmacol
Ou X, Yu Z, Pan C, Zheng X, Li D, Qiao Z, Zheng X.   +6 more
europepmc   +1 more source

Gut microbiota and its metabolites regulate insulin resistance: traditional Chinese medicine insights for T2DM. [PDF]

Front Microbiol
Liu J, Li F, Yang L, Luo S, Deng Y.
europepmc   +1 more source