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Safflower injection against obesity-induced mice podocyte injury by improving insulin resistance through increasing renal INSR and eNOS expression. [PDF]
Ren FailHan Z +5 more
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Insulin receptor and cancer [PDF]
Endocrine-Related Cancer, 2011 The widespread epidemic of obesity and type 2 diabetes has raised concern for the impact of these disorders as risk factors for cancer and has renewed the interest for studies regarding the involvement of hyperinsulinemia and insulin receptor (IR) in cancer progression.
Belfiore, Antonino +1 more
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Insulin, insulin receptors, and cancer
Journal of Endocrinological Investigation, 2016Insulin is a major regulator of cell metabolism but, in addition, is also a growth factor. Insulin effects in target cells are mediated by the insulin receptor (IR), a transmembrane protein with enzymatic (tyrosine kinase) activity. The insulin receptor, however, is represented by a heterogeneous family of proteins, including two different IR isoforms ...
Vigneri R +2 more
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Ketoacids and the insulin receptor
Diabetes, 1978The binding of insulin to a specific receptor on IM-9-cultured human lymphocytes was studied in vitro under conditions simulating diabetic ketoacidosis. Compared with control incubations at pH 7.4, binding was reduced by 19 per cent at pH 7.1 and by 48 per cent at pH 6.8. Addition of β-hydroxybutyrate, at concentrations similar to those seen clinically,
Steven A Lofton +3 more
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Effect of insulin receptor autophosphorylation on insulin receptor binding
Molecular and Cellular Endocrinology, 1986Insulin receptor beta-subunit autophosphorylation, the first event occurring after insulin binding, plays a crucial role in modulation of receptor-associated kinase activity towards exogenous substrates and possibly in the transmission of biological signals of insulin. Receptor autophosphorylation strongly depends on insulin receptor occupancy.
Gherzi R +3 more
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Diabetes, 1972
Studies with bulky and insoluble insulin derivatives indicate that this hormone can activate various metabolic processes by interaction with cell surface structures. A definition of “receptor” is offered which is operationally useful in studies directed to the identification and purification of receptor structures.
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Studies with bulky and insoluble insulin derivatives indicate that this hormone can activate various metabolic processes by interaction with cell surface structures. A definition of “receptor” is offered which is operationally useful in studies directed to the identification and purification of receptor structures.
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THE ERYTHROCYTE INSULIN RECEPTOR
Australian Journal of Experimental Biology and Medical Science, 1981SummaryA precise, reproducible radioreceptor assay has been developed for insulin receptors on human erythrocytes. The mean specific binding in 11 normal volunteers was 7.7% ± 1.6 (S.D.) per 2.25 × 109 erythrocytes. The intra and inter assay coefficients of variation are 4%.
A McElduff, CJ Eastman
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The insulin receptor and the kidney
Current Opinion in Nephrology and Hypertension, 2013In recent years, it has become clear that the insulin receptor is important in a variety of renal cell types. It is through this transmembrane receptor that insulin, and to a lesser extent insulin-like growth factor, hormones bind and can control important cellular functions.
Hale, Lorna J, Coward, Richard J M
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Pathologie Biologie, 2003
The number of elderly people is increasing worldwide as well as the age-associated diseases, such as the type 2 diabetes. The consequences are disastrous for elderly patients as well as for healthy ageing. It has been clinically demonstrated that with physiological ageing it exists already a resistance to the action of insulin leading to slightly ...
Anis Larbi, Tamas Fulop, Nadine Douziech
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The number of elderly people is increasing worldwide as well as the age-associated diseases, such as the type 2 diabetes. The consequences are disastrous for elderly patients as well as for healthy ageing. It has been clinically demonstrated that with physiological ageing it exists already a resistance to the action of insulin leading to slightly ...
Anis Larbi, Tamas Fulop, Nadine Douziech
openaire +3 more sources