Results 41 to 50 of about 3,525,166 (333)

Landmarks in insulin research

Frontiers in Endocrinology, 2011
Ever since the discovery of insulin and its role in the regulation of glucose uptake and utilization, there has been great interest in insulin, its structure and the way in which it interacts with its receptor and effects signal transduction. As the 90th
Michael eLawrence, Michael eLawrence
doaj   +1 more source

S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance.

Diabetes, 2005
Evidence demonstrates that exogenous nitric oxide (NO) and the NO produced by inducible nitric oxide synthase (iNOS) can induce insulin resistance in muscle.
M. A. Carvalho-Filho, M. Ueno, S. Hirabara, A. Seabra, J. Carvalheira, M. D. de Oliveira, L. Velloso, R. Curi, M. J. Saad   +8 more
semanticscholar   +1 more source

Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways [PDF]

, 2018
Chemerin and its G protein-coupled receptor [chemerin receptor 23 (ChemR23)] have been associated with endothelial dysfunction, inflammation, and insulin resistance.
Alves-Lopes, Rheure, da Costa, Rafael Menezes, Harvey, Katie Yates, Lobato, Nubia Souza, Montezano, Augusto Cesar, Neves, Karla Bianca, Nguyen Dinh Cat, Aurelie, Oliveira, Ana Maria, Tostes, Rita C., Touyz, Rhian M.   +9 more
core   +1 more source

Effect of diet-induced obesity on protein expression in insulin signalling pathways of skeletal muscle in male Wistar rats [PDF]

, 2012
BACKGROUND: The prevalence of diet-induced obesity is increasing globally, and posing significant health problems for millions of people worldwide. Diet-induced obesity is a major contributor to the global pandemic of type 2 diabetes mellitus.
Abubakari, Abdul-Razak, Fatani, Sameer, Itua, Imose, Naderali, Ebrahim K., Thomas, Cecil, Wong, Christopher   +5 more
core   +2 more sources

Intra-islet GLP-1, but not CCK, is necessary for β-cell function in mouse and human islets [PDF]

, 2020
Glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK) are gut-derived peptide hormones known to play important roles in the regulation of gastrointestinal motility and secretion, appetite, and food intake.
Davis, Dawn, de Souza, Arnaldo Henrique, Kibbe, Carly R., Linnemann, Amelia K., Merrins, Matthew J., Saghafi, Samuel T., Tang, Jiayin, Yadev, Amanjot Kaur   +7 more
core   +1 more source

Insulin analogs and cancer

Frontiers in Endocrinology, 2012
Today, insulin analogs are used in millions of diabetic patients. Insulin analogs have been developed to achieve more physiological insulin replacement in terms of time course of the effect.
Laura eSciacca, Rosario eLe Moli, Riccardo eVigneri   +2 more
doaj   +1 more source

Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice.

Journal of Endocrinology, 2002
In the present study we have used hypopituitary Ames dwarf mice, which lack GH, prolactin and TSH, to investigate the consequences of the deficiency of these hormones on glucose homeostasis and on the initial components of the insulin signal transduction
F. Dominici, S. Hauck, D. P. Argentino, A. Bartke, D. Turyn   +4 more
semanticscholar   +1 more source

Identification and characterization of insulin-like growth factor receptors on adult rat cardiac myocytes: linkage to inositol 1,4,5-trisphosphate formation. [PDF]

, 1992
Cultured cardiac myocytes from adult Sprague-Dawley rats express both insulin-like growth factor-I (IGF-I) receptors and insulin-like growth factor-II/mannose 6-phosphate (IGF-II/Man6P) receptors and respond to IGF-I with a dose-dependent accumulation of
Berg, Ingeborg, Funk, Barbara, Gercken, Günther, Guse, Andreas H., Kessler, Ulrike, Kiess, Wieland   +5 more
core   +1 more source

Adapter Function of Protein-tyrosine Phosphatase 1D in Insulin Receptor/Insulin Receptor Substrate-1 Interaction (*)

Journal of Biological Chemistry, 1995
Insulin signal transduction involves the multisite docking protein insulin receptor substrate-1 (IRS-1) and a number of Src homology-2 (SH2) domain factors, including p85/p110 phosphatidylinositol 3-kinase, p110 GTPase-activating protein, and the ...
A. Kharitonenkov, J. Schnekenburger, Zhengjun Chen, P. Knyazev, Suhad Ali, Esther Zwick, M. White, A. Ullrich   +7 more
semanticscholar   +1 more source

Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats.

Endocrinology, 1996
Insulin stimulates the tyrosine kinase activity of its receptor, resulting in the phosphorylation of its cytosolic substrate, insulin receptor substrate-1 (IRS-1), which, in turn, associates with phosphatidylinositol 3-kinase (PI 3-kinase), thereby ...
Carla, R., 0., Carvalho, Sigisfredo, L., Brenelli, Ana, C., Silva, André, B., Nunes, Licio, A., Velloso, Mário, J., Saad   +18 more
semanticscholar   +1 more source