Results 41 to 50 of about 3,230,451 (211)
Tissue-specific regulation of IRS-1 in unilaterally nephrectomized rats
Brazilian Journal of Medical and Biological Research, 1997 Insulin stimulates the tyrosine kinase activity of its receptor, resulting in the phosphorylation of its cytosolic substrate, insulin receptor substrate 1 (IRS-1).
A.D. Sasse +5 more
doaj +1 more source
Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa
Cell Death and Disease, 2022 Synaptic loss, neuronal death, and circuit remodeling are common features of central nervous system neurodegenerative disorders. Retinitis pigmentosa (RP), the leading cause of inherited blindness, is a group of retinal dystrophies characterized by ...
Alonso Sánchez-Cruz +9 more
doaj +1 more source
Insulin signaling and its application
Frontiers in Endocrinology, 2023 The discovery of insulin in 1921 introduced a new branch of research into insulin activity and insulin resistance. Many discoveries in this field have been applied to diagnosing and treating diseases related to insulin resistance.
Thi Kim Chung Le +9 more
doaj +1 more source
Haematologica, 2012 Background In normal platelets, insulin inhibits agonist-induced Ca2+ mobilization by raising cyclic AMP. Platelet from patients with type 2 diabetes are resistant to insulin and show increased Ca2+ mobilization, aggregation and procoagulant activity. We
Anja J. Gerrits +5 more
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The impact of acute rosiglitazone on insulin pharmacokinetics at the blood‐brain barrier
Endocrinology, Diabetes & Metabolism, 2020 Introduction CNS insulin levels are decreased and insulin receptor signalling is dampened in Alzheimer's disease (AD). Increasing CNS insulin levels through a variety of methods has been shown to improve memory.
Demi C. Galindo +2 more
doaj +1 more source
New Twist on Neuronal Insulin Receptor Signaling in Health, Disease, and Therapeutics
Journal of Pharmacological Sciences, 2005 Long after the pioneering studies documenting the existence of insulin (year 1967) and insulin receptor (year 1978) in brain, the last decade has witnessed extraordinary progress in the understanding of brain region-specific multiple roles of insulin ...
Akihiko Wada +3 more
doaj +1 more source
Nature Communications, 2013 The gut microbiota affects nutrient acquisition and energy regulation of the host, and can influence the development of obesity, insulin resistance, and diabetes.
I. Kimura +14 more
semanticscholar +1 more source
Brain Insulin Resistance: Focus on Insulin Receptor-Mitochondria Interactions
Life, 2021 Current hypotheses implicate insulin resistance of the brain as a pathogenic factor in the development of Alzheimer’s disease and other dementias, Parkinson’s disease, type 2 diabetes, obesity, major depression, and traumatic brain injury.
Igor Pomytkin, Vsevolod Pinelis
doaj +1 more source
Journal of Biological Chemistry, 2002 Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase (PI3-kinase). To examine the mechanism by which
Chunli Yu +13 more
semanticscholar +1 more source
ATP sensitizes the insulin receptor to insulin. [PDF]
Proceedings of the National Academy of Sciences, 1988 Insulin receptor with high insulin binding and tyrosine kinase activities has been prepared from human placenta. Based on a molecular mass of 306 kDa for the receptor (the value obtained from the sum of the amino acid residues), this preparation is capable of binding 1.48 mol of insulin per mol of receptor.
Kevin D. Ridge +2 more
openaire +3 more sources