Results 111 to 120 of about 6,575 (222)
Melatonin alleviates aging-related heart failure through melatonin receptor 1A/B knockout in mice
HeliyonAge-related cardiovascular diseases continue to be important issues that contribute to the societal burden. Unveiling the molecular mechanisms underlying age-related cardiovascular diseases provides novel opportunities to delay aging and facilitate early
Zhenyu Feng +6 more
doaj +1 more source
Sites of action of sleep and wake drugs: insights from model organisms [PDF]
, 2013 Small molecules have been used since antiquity to regulate our sleep. Despite the explosion of diverse drugs to treat problems of too much or too little sleep, the detailed mechanisms of action and especially the neuronal targets by which these compounds
Rihel, J, Schier, AF
core +1 more source
The role of the mammalian prion protein in the control of sleep [PDF]
, 2017 Sleep disruption is a prevalent clinical feature in many neurodegenerative disorders, including human prion diseases where it can be the defining dysfunction, as in the case of the “eponymous” fatal familial insomnia, or an early-stage symptom as in ...
Gill, Andrew C., Roguski, Amber
core +2 more sources
Anti-oxidants in Parkinson's disease therapy: a critical point of view [PDF]
, 2016 Parkinson's disease (PD) is a degenerative neurological syndrome, which is characterized by the preferential death of dopaminergic (DAergic) neurons in the SubstantiaNigra.
Beltramini, Mariano +3 more
core +2 more sources
Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression [PDF]
, 2007 G protein-coupled receptors are key regulators of cellular communication, mediating the efficient coordination of a cell's responses to extracellular stimuli.
New, David C., Wong, Yung Hou
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Chimeric Melatonin mt1 and Melatonin-related Receptors [PDF]
Journal of Biological Chemistry, 2000 Shaun Conway +5 more
openaire +1 more source
[MT1 melatonin receptors and their role in the oncostatic action of melatonin].
Postepy higieny i medycyny doswiadczalnej (Online), 2010 Melatonin, the main hormone produced by the pineal gland, strongly inhibits the growth of cancer cells in vitro and in vivo. Some publications indicate that the addition of melatonin to culture medium slows the proliferation of some cancer cell lines.
Karolina, Danielczyk, Piotr, Dziegiel
openaire +1 more source
Melatonin: A Molecule for Reducing Breast Cancer Risk [PDF]
, 2018 The objective of this article is to review the basis supporting the usefulness of melatonin as an adjuvant therapy for breast cancer (BC) prevention in several groups of individuals at high risk for this disease.
González González, Alicia +2 more
core +3 more sources
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2011 In bile duct-ligated (BDL) rats, large cholangiocytes proliferate by activation of cAMP-dependent signaling. Melatonin, which is secreted from pineal gland as well as extrapineal tissues, regulates cell mitosis by interacting with melatonin receptors (MT1 and MT2) modulating cAMP and clock genes.
Anastasia, Renzi +15 more
openaire +3 more sources
Melatonin MT1 and MT2 receptor expression in Parkinson's disease.
Medical science monitor : international medical journal of experimental and clinical research, 2010 Idiopathic Parkinson disease (PD) is a multi-system disorder with a multifactorial etiology and diverse clinical phenotype. Selective, regional dopaminergic neuronal degeneration in the substantia nigra and other CNS areas including the amygdala are observed in all patients.
Nikhil, Adi +5 more
openaire +1 more source