Results 91 to 100 of about 6,575 (222)

The role of agomelatine in appetite regulation and body weight in rats

Experimental Physiology, Volume 111, Issue 4, Page 1808-1818, 1 April 2026.
Abstract The hypothalamic nuclei play a central role in the synthesis of anorexigenic and orexigenic neuropeptides, which are regulated by peripheral hormones, like leptin and ghrelin. Melatonergic receptors (MT1/MT2) are prominently expressed in the arcuate nucleus of the hypothalamus – an essential hub for appetite control – and in peripheral ...
Engin Korkmaz, Yavuz Erden, Çiğdem Tekin, Suat Tekin   +3 more
wiley   +1 more source

Behavioral Phenotype and Neuropsychological Profile of an Adult With Smith‐Magenis Syndrome due to a Previously Unreported RAI1 Mutation: A Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Smith‐Magenis Syndrome (SMS) is an uncommon genetic disorder caused by microdeletions of chromosome 17p11.2 including the RAI1 gene, or loss‐of‐function mutations that directly affect RAI1. Due to the involvement of RAI1 in neurodevelopment, SMS leads to typical pathologic features in the behavioral and physical phenotype that must be ...
Edgar Andrés Chavarría‐Martínez, Julen Arellano‐Sandúa, Ruth Arias‐Hidalgo, Ana Patiño‐García, Adrián Cano‐Prous   +4 more
wiley   +1 more source

Structure-based discovery of potent and selective melatonin receptor agonists

eLife, 2020
Melatonin receptors MT1 and MT2 are involved in synchronizing circadian rhythms and are important targets for treating sleep and mood disorders, type-2 diabetes and cancer.
Nilkanth Patel, Xi Ping Huang, Jessica M Grandner, Linda C Johansson, Benjamin Stauch, John D McCorvy, Yongfeng Liu, Bryan Roth, Vsevolod Katritch   +8 more
doaj   +1 more source

Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway [PDF]

Sirtuin1 (SIRT1) and forkhead box transcription factor O subfamily 1 (FOXO1) play vital roles in the maintenance of hippocampal neuronal homeostasis during aging. Our previous study showed that melatonin, a hormone mainly secreted by the pineal gland,
Boontem, Parichart, Govitrapong, Piyarat, Jenwitheesuk, Anorut, Mukda, Sujira, Tocharus, Jiraporn, Wongchitrat, Prapimpun   +5 more
core   +1 more source

Ultrastructural evidence of a secretory role for melatonin in the human parotid gland [PDF]

, 2015
In vivo animal studies show that pentagastrin, cholecystokinin and melatonin cause the secretion and synthesis of salivary proteins. Melatonin occurs in large amounts in the gut and is released into the blood on food intake.
Ekstrom, J., ISOLA, MICHELA, ISOLA, RAFFAELLA, LILLIU, MARIA ALBERTA, LOY, FRANCESCO, PUXEDDU, ROBERTO, SOLINAS, PAOLA   +6 more
core  

The melatonergic system in mood and anxiety disorders and the role of agomelatine: implications for clinical practice [PDF]

, 2013
Melatonin exerts its actions through membrane MT1/MT2 melatonin receptors, which belong to the super family of G-protein-coupled receptors consisting of the typical seven transmembrane domains.
De Berardis D., di Giannantonio M., Fornaro Michele, Iasevoli Felice, Marini S., Martinotti G., Perna G., Quera-Salva M. A., Srinivasan V., Tomasetti C., Valchera A.   +10 more
core   +2 more sources

Quercetin and Its Nano‐Based Formulations Against Skin Cancer: A Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Skin cancer is one of the most prevalent malignancies worldwide, characterized by the abnormal growth of skin cells and significant clinical challenges. Conventional treatments—including surgery, chemotherapy, and radiotherapy—often suffer from limitations such as adverse side effects, tumor resistance, and inadequate efficacy.
Mahtab Khanyabzadeh, Alireza Emamifar, Nikoo Emtiazi, Amir Nazari, Masoumeh Shekarriz, Amin Karami, Fateme Hashem Beik Mahallati, Rahineh Nomani Lafmejani, Atieh Dariush, Seyed Mohammad Mahdi Rohani, Elaheh Mohseni Vadeghani, Negin Khoshnood, Hamid Reza Ojaghi, Fatemeh Rezaei‐Tazangi, Reza Arefnezhad   +14 more
wiley   +1 more source

Modulation of human ovarian function by melatonin

Frontiers in Bioscience-Elite, 2020
Melatonin, a hormone which is primarily released by the pineal gland, has a wide range of actions in the female reproductive tract. While the melatonin receptor subtype, MT3, has been identified in amphibian animals and birds, in humans and other mammals,
Seema Rai, Hindole Gosh
doaj   +1 more source

Gene and protein patterns of potential prion-related markers in the central nervous system of clinical and preclinical infected sheep [PDF]

, 2013
The molecular pathogenic mechanisms of prion diseases are far from clear. Genomic analyses have revealed genetic biomarkers potentially involved in prion neuropathology in naturally scrapie-infected sheep, a good animal model of infectious prionopathies.
Antonia Vargas, Enric Vidal, Filali, Hicham, Hicham Filali, Inmaculada Martin-Burriel, Juan J Badiola, Martí Pumarola, Mercedes Márquez, Paola Marco, Rosa Bolea   +9 more
core   +4 more sources

MT1 melatonin receptor mRNA tissular localization by PCR amplification.

Neuro endocrinology letters, 2003
The pineal gland transduces photoperiodic informations to the neuroendocrine axis through the nocturnally melatonin secretion. This hormonal message plays a major role in the biological rhythm regulation. By autoradiography, more than 130 melatonin putative targets have been reported in the central nervous system (CNS) and in peripheral tissues ...
Poirel, Vincent Joseph, Cailotto, Cathy, Streicher, Dominique, Pevet, Paul, Masson-Pevet, Mireille, Gauer, Francois   +5 more
openaire   +2 more sources