Results 81 to 90 of about 6,575 (222)

T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets

Aging Cell, Volume 25, Issue 5, May 2026.
Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu, Ming Yang, Fugang Xiao, Jinrong Zeng   +3 more
wiley   +1 more source

Remodeling Of The Bone Tissue Of Rats Of Different Lines After Melatonin Effect [PDF]

, 2016
The markers of remodeling of bone tissue (BT) were studied after the impact of pharmacologic dose of melatonin (5 mg/kg of the animal body weight) during 28 days for 3-months rats-males of Wistar and SHR lines.
Berezovskyi, V. (Vadim), Litovka, I. (Irina), Zhernoklov, U. (Uliana)   +2 more
core   +2 more sources

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, Volume 153, Issue 5, Page 402-431, May 2026.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

Melatonin inhibits muscular-mucosal stretch-sensitive bladder afferents via the MT2 receptors

Scientific Reports, 2022
Melatonin is a circadian rhythm regulator capable of controlling a variety of physiological processes in the body. It predominantly acts via the melatonin 1 (MT1) and MT2 receptors expressed in the CNS neurons and peripheral organs and tissues. Melatonin
Stewart Ramsay, Vladimir Zagorodnyuk
doaj   +1 more source

The potential anti-cancer effects of melatonin on breast cancer

Exploration of Medicine, 2022
Melatonin is the primary hormone of the pineal gland that is secreted at night. It regulates many physiological functions, including the sleep-wake cycle, gonadal activity, free radical scavenging, immunomodulation, neuro-protection, and cancer ...
Naba Kumar Das, Saptadip Samanta
doaj   +1 more source

N-(Phenoxyalkyl)amides as MT1 and MT2 ligands: Antioxidant properties and inhibition of Ca2+/CaM-dependent kinase II [PDF]

, 2013
Recently a series of chiral N-(phenoxyalkyl)amides have been reported as potent MT(1) and MT(2) melatonergic ligands. Some of these compounds were selected and tested for their antioxidant properties by measuring their reducing effect against oxidation ...
A. Carocci, A. Catalano, A. De Palma, A. Lovece, C. Franchini, C. o. Bruno, F. De Santis, G. Lentini, ILLARIO, MADDALENA, M. G. Roselli, M. M. Cavalluzzi, M. R. Rusciano   +11 more
core   +1 more source

Gestational Melatonin Supplementation Attenuates Maternal Sleep Deprivation‐Induced Steatohepatitis Susceptibility in Offspring

Cell Proliferation, Volume 59, Issue 5, May 2026.
Maternal SD during pregnancy enhances the development of diet‐induced NASH in adult offspring of both sexes through an NR4A3‐dependent mechanism, characterised by heightened inflammation and increased apoptosis. Maternal melatonin supplementation effectively alleviates this increased susceptibility to NASH in offspring.
Fei Guo, Zexin Yang, Junsen She, Chen Fang, Yizhi Hu, Hefeng Huang, Ling Gao   +6 more
wiley   +1 more source

The Potential Functions and Beneficial Effects of Melatonin on Cognitive Impairment, Neuroinflammation, Blood–Brain Barrier Leakage, and Synaptic Dysfunction in the Offspring of Mice Exposed to Gestational Intermittent Hypoxia

Brain and Behavior, Volume 16, Issue 4, April 2026.
Melatonin rescues the cognitive deficits induced by gestational intermittent hypoxia exposure in male offspring mice, and these results were associated with neuroinflammation, BBB integrity, and alterations in synaptic function. ABSTRACT Introduction Gestational intermittent hypoxia (GIH), which serves as a model for obstructive sleep apnea (OSA), is ...
Xue‐Yan Li, Yun‐Zhoug Cheng, Yue‐Ming Zhang, Fei Hu, Shi‐Kun Fang, Gui‐Hai Chen, Yu Wang   +6 more
wiley   +1 more source

Melatonin limits paclitaxel-induced mitochondrial dysfunction in vitro and protects against paclitaxel-induced neuropathic pain in the rat [PDF]

, 2017
Acknowledgements Thank you to Professor Ahmet Hoke (Johns Hopkins, Baltimore, USA) for the gift of DRG cells; and to Professor Patrick M. Dougherty (MD Anderson Cancer Center, Texas, USA) for sharing his expertise in the rat model.
Agnello, Aguiar, Amin, Andersen, Andre, Areti, Bagheri, Bartley, Cavaletti, Chaplan, Chen, Chenaf, Cottet-Rousselle, Danilov, Devor, Dickie, Dickie, Duggett, Duggett, Fidanboylu, Finnerup, Flatters, Galley, Gao, Gbahou, Gee, Gilron, Griffiths, Jin, Kidd, Kilkenny, Kinker, Kleggetveit, Krukowski, Lissoni, Lopes, Lowes, Lowes, McCormick, Mills, Mogil, Montuschi, Nahleh, Nooshinfar, Orstavik, Orstavik, Paolo, Petkova, Polomano, Presley, Reiter, Sarma, Selimovic, Seretny, Serra, Shim, Shokrzadeh, Smith, Sookprasert, Sprouse, Tchekalarova, Thalhammer, Torsney, Venegas, Virmani, Wang, Wang, Wang, Xiang, Xiao, Xiao, Yang, Yigitturk, Zhang   +73 more
core   +4 more sources

Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells

Cellular & Molecular Biology Letters, 2019
Melatonin receptors MT1 and MT2 (genes officially named MTNR1A and MTNR1B, respectively) play crucial roles in melatonin-mediated regulation of circadian rhythms, the immune system, and control of reproduction in seasonally breeding animals.
Yuan Gao, Xiaochun Wu, Shuqin Zhao, Yujun Zhang, Hailong Ma, Zhen Yang, Wanghao Yang, Chen Zhao, Li Wang, Quanwei Zhang   +9 more
doaj   +1 more source