Results 71 to 80 of about 6,575 (222)

How to cite curated databases and how to make them citable [PDF]

, 2006
Curated scientific databases such as the IUPHAR database resemble conventional publications such as reference manuals in that they represent the work of a large number of people who both create and revise their contents.
Buneman, Peter
core   +1 more source

Effects of Agomelatine on Sleep Across Populations: A Systematic Review and Meta‐Analysis

Journal of Sleep Research, EarlyView.
ABSTRACT Agomelatine, a melatoninergic antidepressant, is often prescribed to improve sleep disturbance, though meta‐analytic evidence is currently lacking. This systematic review and meta‐analysis assessed its efficacy and tolerability in sleep outcomes compared to placebo.
Anastasios Stefanou, Ioannis Anastasiou, Panagiota Fallon, Eleni Glarou, Nikolaos Christodoulou, Andreas S. Lappas, Vasilios‐Panteleimon Bozikas, Myrto T. Samara   +7 more
wiley   +1 more source

Neural stem cells express melatonin receptors and neurotrophic factors: colocalization of the MTreceptor with neuronal and glial markers [PDF]

, 2004
Background In order to optimize the potential benefits of neural stem cell (NSC) transplantation for the treatment of neurodegenerative disorders, it is necessary to understand their biological characteristics.
McMillan Catherine R, Sharma Rohita, Dao Chung V, Rincón Castro Lyda, Armstrong Kristen J, Niles Lennard P, Doering Laurie C, Kirkham David L   +7 more
core   +1 more source

Empowering Melatonin Therapeutics with Drosophila Models

Diseases, 2021
Melatonin functions as a central regulator of cell and organismal function as well as a neurohormone involved in several processes, e.g., the regulation of the circadian rhythm, sleep, aging, oxidative response, and more.
Cassandra Millet-Boureima, Caroline C. Ennis, Jurnee Jamison, Shana McSweeney, Anna Park, Chiara Gamberi   +5 more
doaj   +1 more source

New quinoxaline derivatives as potential MT₁ and MT₂ receptor ligands. [PDF]

, 2012
Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable ...
Aldana, I. (Ignacio), Ancizu, S. (Saioa), Caignard, D.H. (Daniel-Henry), Castrillo, N. (Nerea), Delagrange, P. (Philippe), Galiano, S. (Silvia), Monge, A. (Antonio), Pérez-Silanes, S. (Silvia)   +7 more
core  

Comment développer un antidépresseur au mécanisme d’action innovant : l’exemple de l’agomélatine [PDF]

, 2005
Divers axes de recherche ont été suivis pour obtenir de nouveaux traitements de la dépression plus efficaces, mieux tolérés et d’action plus rapide. Parmi ces axes de recherche, la mélatonine, synchronisateur endogène des rythmes biologiques chez les ...
Boyer, Pierre-Alain, de Bodinat, Christian, Delalleau, Bruno, Mocaër, Elisabeth   +3 more
core   +1 more source

Human Gastroenteropancreatic Expression of Melatonin and Its Receptors MT1 and MT2

PLOS ONE, 2015
The largest source of melatonin, according to animal studies, is the gastrointestinal (GI) tract but this is not yet thoroughly characterized in humans. This study aims to map the expression of melatonin and its two receptors in human GI tract and pancreas using microarray analysis and immunohistochemistry.Gene expression data from normal intestine and
Söderquist, Fanny, Hellström, Per M., Cunningham, Janet L.   +2 more
openaire   +5 more sources

From “Passive Supplementation” to “Active Repair”: Melatonin Reshapes the Treatment Paradigm for Late‐Onset Hypogonadism by Targeting Leydig Cell Senescence

Aging Cell, Volume 25, Issue 5, May 2026.
Melatonin restores testosterone production in aging Leydig cells by targeting key pathological drivers, particularly oxidative stress and mitochondrial dysfunction. This approach offers a fundamental strategy to reshape the Late‐onset hypogonadism treatment paradigm.
Hui Wu, Gang Ning, Mintao Jian, Ajian Peng, Haoyu Wang, Bonan Li, Xing Zhou   +6 more
wiley   +1 more source

The role and therapeutic potential of melatonin in age-related ocular diseases [PDF]

, 2017
The eye is continuously exposed to solar UV radiation and pollutants, making it prone to oxidative attacks. In fact, oxidative damage is a major cause of age-related ocular diseases including cataract, glaucoma, age-related macular degeneration and ...
Colligris, Basilio, Crooke, Almudena, Huete Toral, Fernando, Pintor, Jesús   +3 more
core   +2 more sources

MT1 and MT2 melatonin receptors play opposite roles in brain cancer progression

Journal of Molecular Medicine, 2021
Primary brain tumors remain among the deadliest of all cancers. Glioma grade IV (glioblastoma), the most common and malignant type of brain cancer, is associated with a 5-year survival rate of
G. S. Kinker, L. H. Ostrowski, P. A. C. Ribeiro, R. Chanoch, S. M. Muxel, I. Tirosh, G. Spadoni, S. Rivara, V. R. Martins, T. G. Santos, R. P. Markus, P. A. C. M. Fernandes   +11 more
openaire   +3 more sources