Results 51 to 60 of about 6,575 (222)

Removal of melatonin receptor type 1 signalling induces dyslipidaemia and hormonal changes in mice subjected to environmental circadian disruption

Endocrinology, Diabetes & Metabolism, 2021
Background Melatonin is a hormone secreted by the pineal gland in a circadian rhythmic manner with peak synthesis at night. Melatonin signalling was suggested to play a critical role in metabolism during the circadian disruption.
Cynthia Tchio, Kenkichi Baba, Giuseppe Piccione, Gianluca Tosini   +3 more
doaj   +1 more source

Characterization of the Mel1c melatoninergic receptor in platypus (Ornithorhynchus anatinus). [PDF]

PLoS ONE, 2018
Melatonin is a neurohormone produced in both animals and plants. It binds at least three G-protein-coupled receptors: MT1 and MT2, and Mel1cGPR. Mammalian GPR50 evolved from the reptilian/avian Mel1c and lost its capacity to bind melatonin in all the ...
Célia Gautier, Sophie-Penelope Guenin, Isabelle Riest-Fery, Tahlia Jade Perry, Céline Legros, Olivier Nosjean, Valerie Simonneaux, Frank Grützner, Jean A Boutin   +8 more
doaj   +1 more source

Rat pial microvascular responses to melatonin during bilateral common carotid artery occlusion and reperfusion [PDF]

, 2011
The present study assessed the in vivo rat pial microvascular responses induced by melatonin during brain hypoperfusion and reperfusion (RE) injury. Pial microcirculation of male Wistar rats was visualized by fluorescence microscopy through a closed ...
Cardaci E, COLANTUONI, ANTONIO, Lapi D, Paterni M, Vagnani S   +4 more
core   +1 more source

The role of melatonin in mood disorders [PDF]

, 2015
Melatonin (N-acetyl-5-methoxytryptamine) has been discovered as a hormone secreted by the pineal gland, even though it is also synthetized in various other organs, tissues, and cells.
Cavuto, Marilde, De Berardis, Domenico, Di Giannantonio, Massimo, Di Nicola, Marco, Fornaro, Michele, Girinelli, Gabriella, Iasevoli, Felice, Martinotti, Giovanni, Mazza, Monica, Orsolini, Laura, Perna, Giampaolo, Piersanti, Monica, Serroni, Nicola, Tomasetti, Carmine, Valchera, Alessandro   +14 more
core   +1 more source

Melatonin antagonizes lipopolysaccharide-induced pulpal fibroblast responses

BMC Oral Health, 2020
Background Pulpal inflammation is known to be mediated by multiple signaling pathways. However, whether melatonin plays regulatory roles in pulpal inflammation remains unclear.
Nutthapong Kantrong, Piyabhorn Jit-Armart, Uthaiwan Arayatrakoollikit   +2 more
doaj   +1 more source

Is there a role for melatonin in fibromyalgia? [PDF]

, 2019
Fibromyalgia, characterised by persistent pain, fatigue, sleep disturbance and cognitive dysfunction, is a central sensitivity syndrome that also involves abnormality in peripheral generators and in the hypothalamic pituitary adrenal axis.
Acuna-Castroviejo D, Escames G, Reiter RJ, Ambriz-Tututi M, Rocha-González HI, Cruz SL, et al., Bunney WE, Bunney BG, Castaño MY, Garrido M, Delgado-Adamez J, et al., Castaño MY, Garrido M, Rodríguez AB, et al., Caumo W, Hidalgo MP, Souza A, et al., Chen WW, Zhang X, Huang WJ., Citera G, Arias MA, Maldonado-Cocco JA, et al., Clauw DJ, Comai S, Gobbi G, de Zanette SA, Vercelino R, Laste G, et al., Fatima G, Das SK, Mahdi AA, Fayed N, Garcia-Campayo J, Magallón R, et al., Hardeland R, Cardinali DP, Srinivasan V, et al., Herrero JF, Laird JM, López-García JA, Hussain SA, Al-Khalifa II, Jasim NA, et al., Ismail SA, Mowafi HA, Laurido C, Pelissie T, Soto-Moyano R, et al., Lawson K, Macfarlane GJ, Kronisch C, Dean LE, et al., Masruha M, de Souza Vieira DS, Minett TS, et al., Masruha MR, Lin J, de Souza Vieira DS, et al., Musshoff U, Riewenherm D, Berger E, et al., Nava F, Carta G, Noseda R, Hernández A, Valladares L, et al., Pardini M, Cordano C, Benassi F, et al., Pyke TL, Osmotherly PG, Baines S, Queiroz LP, Quera Salva MA, Hartley S, Barbot F, et al., San L, Arranz B, Senel K, Baygutalp F, Baykal T, et al., Sluka KA, Clauw DJ, Srinivasan V, Brzezinski A, Pandi-Perumal SR, et al., Srinivasan V, Lauterbach EC, Ho KY, et al., Srinivasan V, Pandi-Perumal SR, Trahkt I, et al., Sánchez-Domínguez B, Bullón P, Román-Malo L, et al., Torres-Farfan C, Richter HG, Rojas-García P, et al., Vanecek J, Wan Q, Man HY, Liu F, et al., Webb SM, Wikner J, Hirsch U, Wetterberg L, et al., Wilhelmsen M, Amirian I, Reiter RJ, et al., Wolfe F, Clauw DJ, Fitzcharles MA, et al., Wood PB, Schweinhardt P, Jaeger E, et al., Üçeyler N, Zeller D, Kahn AK, et al.   +44 more
core   +1 more source

Heteromeric MT ₁ /MT ₂ Melatonin Receptors Modulate Photoreceptor Function [PDF]

Science Signaling, 2013
Melatonin stimulates a heteromeric G protein–coupled receptor to modulate the eye’s response to light flashes at night.
Baba, Kenkichi, Benleulmi-Chaachoua, Abla, Journé, Anne-Sophie, Kamal, Maud, Guillaume, Jean-Luc, Dussaud, Sébastien, Gbahou, Florence, Yettou, Katia, Liu, Cuimei, Contreras-Alcantara, Susana, Jockers, Ralf, Tosini, Gianluca   +11 more
openaire   +3 more sources

Melatonin Synergizes the Chemotherapeutic Effect of Cisplatin in Ovarian Cancer Cells Independently of MT1 Melatonin Receptors [PDF]

In Vivo, 2018
Melatonin (MLT), through the interaction with membrane melatonin receptors MT1, can improve the effectiveness of cytostatic agents, including cisplatin (CP). The aim of this study was to examine the synergistic effect of MLT and CP in three cell lines: IOSE 364, SK-OV-3 and OVCAR-3, as well as to assess the role of MT1 receptors in this mechanism.Using
Agata, Zemła, Irmina, Grzegorek, Piotr, Dzięgiel, Karolina, Jabłońska   +3 more
openaire   +3 more sources

A Review of Melatonin, Its Receptors and Drugs

Eurasian Journal of Medicine, 2019
After a Turkish scientist took Nobel Prize due to his contributions to understand clock genes, melatonin, closely related to these genes, may begin to shine.
Mucahit Emet, Halil Ozcan, Lutfu Ozel, Muhammed Yayla, Zekai Halici, Ahmet Hacimuftuoglu   +5 more
doaj   +1 more source

Myopes have significantly higher serum melatonin concentrations than non-myopes [PDF]

, 2017
Purpose Experimental animal models of myopia demonstrate that higher melatonin (Mel) and lower dopamine (DA) concentrations actively promote axial elongation.
Ackermann, Atkinson, Ayaki, Baba, Barnard, Beck-Friis, Benavente-Pérez, Benloucif, Berg, Bertolet, Besharse, Breslin, Brown, Cahill, Chang, Chiba, Chua, Delgado, Dong, Eisenberg, Fan, Freedman, Guo, Hammond, He, Hua, Huang, Huang, Hughes, Iuvone, Jee, Kivelä, Lanyon, Logan, Lu, Mallen, Mao, Martin, McCullough, Megaw, Megaw, Nickla, Nickla, Ohngemach, Panda, Pendrak, Rada, Rao, Riefahn, Rohrer, Rose, Rudnicka, Sankaridurg, Skene, Stone, Stone, Stormann, Tosini, Trier, Verkicharla, Wahl, Wallman, Wang, Weiss, Wiechmann, Wiechmann, Wilson, Witkovsky, Wu, Xu, Zhang   +70 more
core   +2 more sources