Results 61 to 70 of about 6,575 (222)

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Integrating classical and quantum mechanics in melatonin receptors for structure-guided drug design

Academia Biology
Although melatonin receptor agonists are acknowledged for their therapeutic potential for managing sleep problems, the structural optimization of these compounds is made challenging by variations in crystallographic data.
Gabriela de Lima Menezes, Gabriel Vinícius Rolim da Silva, Katyanna Sales Bezerra, Marielena Vogel Saivish, Clara Sales Gurgel Ribeiro Dantas, Douglas Soares Galvão, John Fontenele Araújo, Jonas Ivan Nobre Oliveira, Roosevelt Alves da Silva, Umberto Laino Fulco   +9 more
doaj   +1 more source

Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis

Neurobiology of Disease, 2013
Caspase-mediated cell death contributes to the pathogenesis of motor neuron degeneration in the mutant SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis (ALS), along with other factors such as inflammation and oxidative damage.
Yi Zhang, Anna Cook, Jinho Kim, Sergei V. Baranov, Jiying Jiang, Karen Smith, Kerry Cormier, Erik Bennett, Robert P. Browser, Arthur L. Day, Diane L. Carlisle, Robert J. Ferrante, Xin Wang, Robert M. Friedlander   +13 more
doaj   +1 more source

Recombinant human melatonin receptor MT1 isolated in mixed detergents shows pharmacology similar to that in mammalian cell membranes. [PDF]

PLoS ONE, 2014
The human melatonin MT1 receptor-belonging to the large family of G protein-coupled receptors (GPCRs)-plays a key role in circadian rhythm regulation and is notably involved in sleep disorders and depression.
Christel Logez, Sylvie Berger, Céline Legros, Jean-Louis Banères, William Cohen, Philippe Delagrange, Olivier Nosjean, Jean A Boutin, Gilles Ferry, Frédéric Simonin, Renaud Wagner   +10 more
doaj   +1 more source

Npas4 is activated by melatonin, and drives the clock gene Cry1 in the ovine pars tuberalis [PDF]

, 2013
Seasonal mammalsintegrate changes in the duration of nocturnal melatonin secretion to drive annual physiologic cycles. Melatonin receptors within the proximal pituitary region, the pars tuberalis (PT), are essential in regulating seasonal neuroendocrine ...
Burt, Dw, Davis, Jre, Dupre, Sm, Loudon, Asi, McNeilly, As, Miedzinska, K, Paton, Bob, West, A, Yu, L   +8 more
core   +1 more source

Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3‐Mediated Mitophagy

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang, Gang Zhang, Ying‐Kai Ma, Xin‐Nan Ma, Song‐Cen Lv   +4 more
wiley   +1 more source

Profile of melatonin and its receptors and synthesizing enzymes in cumulus–oocyte complexes of the developing sheep antral follicle—a potential estradiol-mediated mechanism

Reproductive Biology and Endocrinology, 2019
Background Melatonin is an amine hormone that plays an important role in regulating mammalian reproduction. This study aimed to investigate the expression pattern of melatonin synthesis enzymes AANAT and HIOMT and melatonin receptors MT1 and MT2 in sheep
Longfei Xiao, Junjie Hu, Liangli Song, Yong Zhang, Weitao Dong, Yuting Jiang, Quanwei Zhang, Ligang Yuan, Xingxu Zhao   +8 more
doaj   +1 more source

Monoaminergic Neuropathology in Alzheimer's disease [PDF]

, 2016
Acknowledgments This work was supported by The Croatian Science Foundation grant. no. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Bažadona, Danira, Buée, Luc, Delalle, Ivana, Giovanni, Giuseppe Di, Harrington, Charles R., Hof, Patrick R., Jovanov-Milošević, Nataša, Leko, Mirjana Babić, Silva, Rohan de, Wischik, Claude M., Wray, Selina, Šimić, Goran   +11 more
core   +1 more source

mt1 Melatonin Receptor in the Primate Adrenal Gland: Inhibition of Adrenocorticotropin-Stimulated Cortisol Production by Melatonin [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2003
The pineal hormone melatonin participates in circadian, seasonal, and reproductive physiology. The presence of melatonin binding sites in human brain and peripheral tissues is well documented. However, in the mammalian adrenal gland, low-affinity melatonin binding sites have been detected only in the rat by some but not all authors.
Torres Farfán, Claudia, Richter, Hans G., Rojas García, Pedro, Vergara, Marcela, Forcelledo, María Luisa, Valladares Boasi, Luis, Torrealba, Fernando, Valenzuela, Guillermo J., Serón Ferré, María   +8 more
openaire   +5 more sources

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source