Results 121 to 130 of about 6,476 (207)

Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors

open access: yesAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2011
In bile duct-ligated (BDL) rats, large cholangiocytes proliferate by activation of cAMP-dependent signaling. Melatonin, which is secreted from pineal gland as well as extrapineal tissues, regulates cell mitosis by interacting with melatonin receptors (MT1 and MT2) modulating cAMP and clock genes.
Anastasia, Renzi   +15 more
openaire   +3 more sources

GPR50 is the mammalian ortholog of Mel1c: Evidence of rapid evolution in mammals

open access: yesBMC Evolutionary Biology, 2008
Background The melatonin receptor subfamily contains three members Mel1a, Mel1b and Mel1c, found in all vertebrates except for Mel1c which is found only in fish, Xenopus species and the chicken.
Malpaux Benoit   +6 more
doaj   +1 more source

Melatonin MT1 and MT2 receptor expression in Parkinson's disease.

open access: yesMedical science monitor : international medical journal of experimental and clinical research, 2010
Idiopathic Parkinson disease (PD) is a multi-system disorder with a multifactorial etiology and diverse clinical phenotype. Selective, regional dopaminergic neuronal degeneration in the substantia nigra and other CNS areas including the amygdala are observed in all patients.
Nikhil, Adi   +5 more
openaire   +1 more source

Research on the effects and related mechanisms of geomagnetic storm on depression

open access: yesBrain Research Bulletin
Objective: Depression has become disabling disease in the world. Geomagnetic storm is closely related to depression behavior, and melatonin is an important factor in the pathogenesis of depression. This study observed the effects of different intensities
Hui Wu   +8 more
doaj   +1 more source

Effect of Melatonin on Chemoresistance Exhibited by Spheres Derived from Canine Mammary Carcinoma Cells

open access: yesAnimals
Mammary cancer is a frequent disease in female dogs, where a high proportion of cases correspond to malignant tumors that may exhibit drug resistance. Within the mammary tumor microenvironment, there is a cell subpopulation called cancer stem cells (CSCs)
Dania Cataldo   +5 more
doaj   +1 more source

Association between rs2119882 (MT1A) Melatonin Receptor Polymorphism and Childhood Leukemia Using RFlP-PCR Method

open access: yesJournal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Melatonin is a well-known neuroendocrine reproductive hormone-based hormone that has an important role in the circadian clock system and has potent antioxidant properties.
Mohaddeseh Nemati   +5 more
doaj  

Light pollution during pregnancy influences the growth of offspring in rats

open access: yesEcotoxicology and Environmental Safety
Objective: To investigate the effects of excessive light exposure during gestation on intrauterine development and early growth of neonates in rats. Methods: Pregnant rats were randomly allocated to three groups: the constant light exposure group, non ...
Baojing Zhao   +7 more
doaj   +1 more source

The Effect of Melatonin on Behavioral, Molecular, and Histopathological Changes in Cuprizone Model of Demyelination [PDF]

open access: yes, 2016
Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system. The protective effects of melatonin (MLT) on various neurodegenerative diseases, including MS, have been suggested.
Ghadiri, T.   +6 more
core  

Environmental Control of Annual Reproductive Cycle and Spawning Rhythmicity of Spinefoots [PDF]

open access: yes, 2015
Proceedins of 8th Kuroshio University League Network Formation Toward the Sustainable Society in Kuroshio Region Through Cross-Boader ...
Ayson,Felix   +7 more
core  

MT1/MT2 melatonin receptors in proinflammatory T helper cell populations

open access: yesRussian Journal of Immunology
Melatonin, a pineal gland hormone, is an effective regulator of the main T helper Th1 and Th17 populations. Currently, the studies of T helpers are shifting from classical to non-classical variants of these cells, primarily to Th1-polarized Th17 lymphocytes (Th17.1), which are formed in vitro and in vivo by transformation of differentiated Th17 cells ...
Elena M. Kuklina   +2 more
openaire   +1 more source

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