Results 11 to 20 of about 6,575 (222)
MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations [PDF]
Journal of Pineal Research, 2019 AbstractMelatonin (MLT) exerts its physiological effects principally through two high‐affinity membrane receptors MT1 and MT2. Understanding the exact mechanism of MLT action necessitates the use of highly selective agonists/antagonists to stimulate/inhibit a given MLT receptor. The respective distribution of MT1 and MT2 within the CNS and elsewhere is
Klosen, Paul +6 more
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Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep
Frontiers in Endocrinology, 2019 The pathophysiological function of the G-protein coupled melatonin MT1 and MT2 receptors has not yet been well-clarified. Recent advancements using selective MT1/ MT2 receptor ligands and MT1/MT2 receptor knockout mice have suggested that the activation ...
Gabriella Gobbi +2 more
doaj +3 more sources
Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks. [PDF]
PLoS ONE, 2016 Melatonin is rhythmically secreted by both the pineal gland and retina in a circadian fashion, with its peak synthesis occurring during the night. Once synthesized, melatonin exerts its effects by binding to two specific G-protein coupled receptors ...
Sharon Owino +3 more
doaj +1 more source
Modeling the Heterodimer Interfaces of Melatonin Receptors
Frontiers in Cellular Neuroscience, 2021 Melatonin receptors are Class A G protein-coupled receptors (GPCRs) that regulate a plethora of physiological activities in response to the rhythmic secretion of melatonin from the pineal gland.
Lap Hang Tse +3 more
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Melatonin Transmits Photoperiodic Signals through the MT1 Melatonin Receptor [PDF]
The Journal of Neuroscience, 2009 Melatonin transmits photoperiodic signals that regulate reproduction. Two melatonin receptors (MT1 and MT2) have been cloned in mammals and additional melatonin binding sites suggested, but the receptor that mediates the effects of melatonin on the photoperiodic gonadal response has not yet been identified. We therefore investigated in mice whether and
Shinobu, Yasuo +3 more
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Expression of the MT1 Melatonin Receptor in Ovarian Cancer Cells [PDF]
International Journal of Molecular Sciences, 2014 Ovarian cancer (OC) is the leading cause of death among women with genital tract disorders. Melatonin exhibits oncostatic properties which it may effect through binding to its membrane receptor, MT1. The aim of this study was to determine the expression of MT1 in OC cells and to correlate this with clinical and pathological data.
Karolina Jablonska +9 more
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Frontiers in Cell and Developmental Biology, 2021 It is well known that hypoxanthine (HX) inhibits nuclear maturation of oocytes by elevating the intracellular cAMP level, while melatonin (MT) is a molecule that reduces cAMP production, which may physiologically antagonize this inhibition and restore ...
Jing Wang +11 more
doaj +1 more source
Distribution of Melatonin MT1 Receptor Immunoreactivity in Human Retina [PDF]
Journal of Histochemistry & Cytochemistry, 2002 Melatonin is synthesized in the pineal gland and retina during the night. Retinal melatonin is believed to be involved in local cellular modulation and in regulation of light-induced entrainment of circadian rhythms. The present study provides the first immunohistochemical evidence for the localization of melatonin 1a-receptor (MT1) in human retina of
Savaskan, Egemen +8 more
openaire +3 more sources
Role of melatonin receptors in the effect of estrogen on brain edema, intracranial pressure and expression of aquaporin 4 after traumatic brain injury [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Traumatic brain injury (TBI) is one of the most common causes of death and disability in modern societies. The role of steroids and melatonin is recognized as a neuroprotective factor in traumatic injuries.
Nader Shahrokhi +4 more
doaj +1 more source
Melatonin and the Dental Pulp: A Scoping Review. [PDF]
Int Endod JABSTRACT Background In general medicine, melatonin is known to enhance wound healing and promote stem cell differentiation. Its potential relevance in endodontics, however, remains underexplored. Objectives This scoping review aimed to systematically assess the available evidence on the effects of melatonin (a) on dental pulp tissue and (b) on human ...
Schäfer J, Kleszczynski K, Schäfer E.
europepmc +2 more sources