Results 11 to 20 of about 3,161 (162)

Suicidal Ideation Following a Single Dose of Melatonin in a Patient With Major Depressive Disorder: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Melatonin is a neurohormone that primarily regulates sleep patterns and circadian rhythms by interacting with melatonin receptors MT1 and MT2. Disruptions in circadian rhythms may contribute to mood disorders; for example, individuals with major depressive disorder often have significantly lower melatonin levels compared to healthy individuals.
Badrfam R, Zandifar A.
europepmc   +2 more sources

Melatonin and the Dental Pulp: A Scoping Review. [PDF]

Int Endod J
ABSTRACT Background In general medicine, melatonin is known to enhance wound healing and promote stem cell differentiation. Its potential relevance in endodontics, however, remains underexplored. Objectives This scoping review aimed to systematically assess the available evidence on the effects of melatonin (a) on dental pulp tissue and (b) on human ...
Schäfer J, Kleszczynski K, Schäfer E.
europepmc   +2 more sources

Functional Expression of MT2 (Mel1b) Melatonin Receptors in Human PAZ6 Adipocytes [PDF]

Endocrinology, 2001
Several reports have demonstrated that the pineal hormone, melatonin, plays an important role in body mass regulation in mammals. To date, however, the target tissues and relevant biochemical mechanisms involved remain uncharacterized. As adipose tissue is the principal site of energy storage in the body, we investigated whether melatonin could also ...
L, Brydon, L, Petit, P, Delagrange, A D, Strosberg, R, Jockers   +4 more
openaire   +3 more sources

Anti-Inflammatory Effects of Melatonin in Rats with Induced Type 2 Diabetes Mellitus

Life, 2022
Introduction: Insulin resistance is associated with a pro-inflammatory state increasing the risk for complications in patients with type 2 diabetes mellitus (T2DM).
Hande Yapislar, Ebru Haciosmanoglu, Turkan Sarioglu, Sevgin Degirmencioglu, Ibrahim Sogut, Michael Poteser, Cem Ekmekcioglu   +6 more
doaj   +1 more source

Synthesis and functional characterization of substituted isoquinolinones as MT2-selective melatoninergic ligands. [PDF]

PLoS ONE, 2014
A series of substituted isoquinolinones were synthesized and their binding affinities and functional activities towards human melatonin MT1 and MT2 receptors were evaluated.
Yueqing Hu, King H Chan, Xixin He, Maurice K C Ho, Yung H Wong   +4 more
doaj   +1 more source

Melatonin Receptors: A Key Mediator in Animal Reproduction

Veterinary Sciences, 2022
Melatonin, a hormone produced by the mammalian pineal gland, influences various physiological activities, many of which are related to animal reproduction, including neuroendocrine function, rhythm regulation, seasonal behavior, gonadogenesis, gamete ...
Yuan Gao, Shuqin Zhao, Yong Zhang, Quanwei Zhang   +3 more
doaj   +1 more source

The ubiquitin-specific protease 8 antagonizes melatonin-induced endocytic degradation of MT1 receptor to promote lung adenocarcinoma growth

Journal of Advanced Research, 2022
Introduction: The human genome encodes two melatonin receptors (MT1 and MT2) that relay melatonin signals to cellular interior. Accumulating evidence has linked melatonin to multiple health benefits, among which its anticancer effects have become well ...
Qianhui Sun, Jinrui Zhang, Xiaoxi Li, Guoheng Yang, Shaoxuan Cheng, Dong Guo, Qingqing Zhang, Feng Sun, Feng Zhao, Dian Yang, Shanshan Wang, Taishu Wang, Shuyan Liu, Lijuan Zou, Yingqiu Zhang, Han Liu   +15 more
doaj   +1 more source

Melatonin as a therapy in cardiac ischemia-reperfusion injury: Potential mechanisms by which MT2 activation mediates cardioprotection

Journal of Advanced Research, 2021
Introduction: Previous studies reported the beneficial effects of pretreatment with melatonin on the heart during cardiac ischemia/reperfusion (I/R) injury.
Kodchanan Singhanat, Nattayaporn Apaijai, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Siriporn C. Chattipakorn, Nipon Chattipakorn   +5 more
doaj   +1 more source

MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations [PDF]

Journal of Pineal Research, 2019
AbstractMelatonin (MLT) exerts its physiological effects principally through two high‐affinity membrane receptors MT1 and MT2. Understanding the exact mechanism of MLT action necessitates the use of highly selective agonists/antagonists to stimulate/inhibit a given MLT receptor. The respective distribution of MT1 and MT2 within the CNS and elsewhere is
Klosen, Paul, Lapmanee, Sarawut, Schuster, Carole, Guardiola, Béatrice, Hicks, David, Pevet, Paul, Felder‐schmittbuhl, Marie Paule   +6 more
openaire   +3 more sources

Characterization of the Mel1c melatoninergic receptor in platypus (Ornithorhynchus anatinus). [PDF]

PLoS ONE, 2018
Melatonin is a neurohormone produced in both animals and plants. It binds at least three G-protein-coupled receptors: MT1 and MT2, and Mel1cGPR. Mammalian GPR50 evolved from the reptilian/avian Mel1c and lost its capacity to bind melatonin in all the ...
Célia Gautier, Sophie-Penelope Guenin, Isabelle Riest-Fery, Tahlia Jade Perry, Céline Legros, Olivier Nosjean, Valerie Simonneaux, Frank Grützner, Jean A Boutin   +8 more
doaj   +1 more source