Results 31 to 40 of about 5,798 (220)

Circadian Pattern of Melatonin MT1 and MT2 Receptor Localization in the Rat Suprachiasmatic Nucleus

Journal of Circadian Rhythms, 2015
The suprachiasmatic nucleus (SCN) is the circadian pacemaker. The pineal hormone melatonin is involved in the regulation of circadian phase. As a part of the circadian system its synthesis and secretion is under SCN control.
Nermien Waly, Richard Hallworth
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Melatonin Alleviates Acute Sleep Deprivation-Induced Memory Loss in Mice by Suppressing Hippocampal Ferroptosis

Frontiers in Pharmacology, 2021
Objectives: Memory decline caused by insufficient sleep is a critical public health issues and currently lacks effective treatments. This study objective was to explore alleviative effect of melatonin on sleep deprivation (SD)-induced deficiencies in ...
Xintong Wang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen   +4 more
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Rat pial microvascular responses to melatonin during bilateral common carotid artery occlusion and reperfusion [PDF]

, 2011
The present study assessed the in vivo rat pial microvascular responses induced by melatonin during brain hypoperfusion and reperfusion (RE) injury. Pial microcirculation of male Wistar rats was visualized by fluorescence microscopy through a closed ...
Cardaci E, COLANTUONI, ANTONIO, Lapi D, Paterni M, Vagnani S   +4 more
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Heteromeric MT ₁ /MT ₂ Melatonin Receptors Modulate Photoreceptor Function [PDF]

Science Signaling, 2013
Melatonin stimulates a heteromeric G protein–coupled receptor to modulate the eye’s response to light flashes at night.
Baba, Kenkichi, Benleulmi-Chaachoua, Abla, Journé, Anne-Sophie, Kamal, Maud, Guillaume, Jean-Luc, Dussaud, Sébastien, Gbahou, Florence, Yettou, Katia, Liu, Cuimei, Contreras-Alcantara, Susana, Jockers, Ralf, Tosini, Gianluca   +11 more
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The role of melatonin in mood disorders [PDF]

, 2015
Melatonin (N-acetyl-5-methoxytryptamine) has been discovered as a hormone secreted by the pineal gland, even though it is also synthetized in various other organs, tissues, and cells.
Cavuto, Marilde, De Berardis, Domenico, Di Giannantonio, Massimo, Di Nicola, Marco, Fornaro, Michele, Girinelli, Gabriella, Iasevoli, Felice, Martinotti, Giovanni, Mazza, Monica, Orsolini, Laura, Perna, Giampaolo, Piersanti, Monica, Serroni, Nicola, Tomasetti, Carmine, Valchera, Alessandro   +14 more
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Melatonin Promotes Heterotopic Ossification Through Regulation of Endothelial-Mesenchymal Transition in Injured Achilles Tendons in Rats

Frontiers in Cell and Developmental Biology, 2021
Although heterotopic ossification (HO) has been reported to be a common complication of the posttraumatic healing process, the underlying mechanism remains unknown.
Jie Zhang, Jie Zhang, Jiajun Tang, Jiajun Tang, Jie Liu, Jie Liu, Bo Yan, Bo Yan, Bin Yan, Bin Yan, Minjun Huang, Minjun Huang, Zhongmin Zhang, Liang Wang, Liang Wang   +14 more
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Is there a role for melatonin in fibromyalgia? [PDF]

, 2019
Fibromyalgia, characterised by persistent pain, fatigue, sleep disturbance and cognitive dysfunction, is a central sensitivity syndrome that also involves abnormality in peripheral generators and in the hypothalamic pituitary adrenal axis.
Acuna-Castroviejo D, Escames G, Reiter RJ, Ambriz-Tututi M, Rocha-González HI, Cruz SL, et al., Bunney WE, Bunney BG, Castaño MY, Garrido M, Delgado-Adamez J, et al., Castaño MY, Garrido M, Rodríguez AB, et al., Caumo W, Hidalgo MP, Souza A, et al., Chen WW, Zhang X, Huang WJ., Citera G, Arias MA, Maldonado-Cocco JA, et al., Clauw DJ, Comai S, Gobbi G, de Zanette SA, Vercelino R, Laste G, et al., Fatima G, Das SK, Mahdi AA, Fayed N, Garcia-Campayo J, Magallón R, et al., Hardeland R, Cardinali DP, Srinivasan V, et al., Herrero JF, Laird JM, López-García JA, Hussain SA, Al-Khalifa II, Jasim NA, et al., Ismail SA, Mowafi HA, Laurido C, Pelissie T, Soto-Moyano R, et al., Lawson K, Macfarlane GJ, Kronisch C, Dean LE, et al., Masruha M, de Souza Vieira DS, Minett TS, et al., Masruha MR, Lin J, de Souza Vieira DS, et al., Musshoff U, Riewenherm D, Berger E, et al., Nava F, Carta G, Noseda R, Hernández A, Valladares L, et al., Pardini M, Cordano C, Benassi F, et al., Pyke TL, Osmotherly PG, Baines S, Queiroz LP, Quera Salva MA, Hartley S, Barbot F, et al., San L, Arranz B, Senel K, Baygutalp F, Baykal T, et al., Sluka KA, Clauw DJ, Srinivasan V, Brzezinski A, Pandi-Perumal SR, et al., Srinivasan V, Lauterbach EC, Ho KY, et al., Srinivasan V, Pandi-Perumal SR, Trahkt I, et al., Sánchez-Domínguez B, Bullón P, Román-Malo L, et al., Torres-Farfan C, Richter HG, Rojas-García P, et al., Vanecek J, Wan Q, Man HY, Liu F, et al., Webb SM, Wikner J, Hirsch U, Wetterberg L, et al., Wilhelmsen M, Amirian I, Reiter RJ, et al., Wolfe F, Clauw DJ, Fitzcharles MA, et al., Wood PB, Schweinhardt P, Jaeger E, et al., Üçeyler N, Zeller D, Kahn AK, et al.   +44 more
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Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions

Scientific Reports, 2017
Understanding the function of orphan G protein-coupled receptors (GPCRs), whose cognate ligand is unknown, is of major importance as GPCRs are privileged drug targets for many diseases. Recent phylogenetic studies classified three orphan receptors, GPR61,
Atsuro Oishi, Angeliki Karamitri, Romain Gerbier, Olivier Lahuna, Raise Ahmad, Ralf Jockers   +5 more
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Profile of melatonin and its receptors and synthesizing enzymes in cumulus–oocyte complexes of the developing sheep antral follicle—a potential estradiol-mediated mechanism

Reproductive Biology and Endocrinology, 2019
Background Melatonin is an amine hormone that plays an important role in regulating mammalian reproduction. This study aimed to investigate the expression pattern of melatonin synthesis enzymes AANAT and HIOMT and melatonin receptors MT1 and MT2 in sheep
Longfei Xiao, Junjie Hu, Liangli Song, Yong Zhang, Weitao Dong, Yuting Jiang, Quanwei Zhang, Ligang Yuan, Xingxu Zhao   +8 more
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Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction [PDF]

Journal of Psychopharmacology, 2021
Background: Aside from regulating circadian rhythms, melatonin also affects cognitive processes, such as alertness, and modulates the brain circuitry underlying psychiatric diseases, such as depression, schizophrenia and bipolar disorder, via mechanisms that are not fully clear.
Thomson, David M., Mitchell, Emma J., Openshaw, Rebecca L., Pratt, Judith A., Morris, Brian J.   +4 more
openaire   +5 more sources