Abnormal hippocampal melatoninergic system: a potential link between absence epilepsy and depression-like behavior in WAG/Rij rats? [PDF]
, 2018 Absence epilepsy and depression are comorbid disorders, but the molecular link between the two disorders is unknown. Here, we examined the role of the melatoninergic system in the pathophysiology of spike and wave discharges (SWDs) and depression-like ...
Battaglia, Giuseppe +8 more
core +1 more source
Monoaminergic Neuropathology in Alzheimer's disease [PDF]
, 2016 Acknowledgments This work was supported by The Croatian Science Foundation grant. no. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Bažadona, Danira +11 more
core +1 more source
Journal of Advanced Research, 2021 Introduction: Previous studies reported the beneficial effects of pretreatment with melatonin on the heart during cardiac ischemia/reperfusion (I/R) injury.
Kodchanan Singhanat +5 more
doaj +1 more source
Characterization of the Mel1c melatoninergic receptor in platypus (Ornithorhynchus anatinus). [PDF]
PLoS ONE, 2018 Melatonin is a neurohormone produced in both animals and plants. It binds at least three G-protein-coupled receptors: MT1 and MT2, and Mel1cGPR. Mammalian GPR50 evolved from the reptilian/avian Mel1c and lost its capacity to bind melatonin in all the ...
Célia Gautier +8 more
doaj +1 more source
Recent advances on the mechanisms regulating cholangiocyte proliferation and the significance of the neuroendocrine regulation of cholangiocyte pathophysiology [PDF]
, 2013 Cholangiocytes are epithelial cells lining the biliary epithelium. Cholangiocytes play several key roles in the modification of ductal bile and are also the target cells in chronic cholestatic liver diseases (i.e., cholangiopathies) such as PSC, PBC ...
Alvaro, Domenico +6 more
core +1 more source
Melatonin Inhibits NF-κB/CREB/Runx2 Signaling and Alleviates Aortic Valve Calcification
Frontiers in Cardiovascular Medicine, 2022 Calcific aortic valve disease (CAVD) is linked to high mortality. Melatonin inhibits nuclear factor-kappa B (NF-κB)/cyclic AMP response element-binding protein (CREB), contributing to CAVD progression.
Shao-Jung Li +20 more
doaj +1 more source
Melatonin receptor expression in the zebra finch brain and peripheral tissues [PDF]
, 2012 The circadian endocrine hormone melatonin plays a significant role in many physiological processes such as modulating sleep/wake cycle and oxidative stress.
Brandstaetter, Roland +2 more
core +1 more source
MT2 selective melatonin receptor antagonists: design and structure-activity relationships [PDF]
Arkivoc, 2006 The neurohormone melatonin is involved in the regulation of many physiological functions, in particular those related to circadian and seasonal rhythms. In mammals, melatonin activates two GPCRs, named MT1 and MT2, and ligands of these receptors have been proposed for the treatment of different pathologies.
RIVARA, Silvia +6 more
openaire +2 more sources
Melatonin antagonizes lipopolysaccharide-induced pulpal fibroblast responses
BMC Oral Health, 2020 Background Pulpal inflammation is known to be mediated by multiple signaling pathways. However, whether melatonin plays regulatory roles in pulpal inflammation remains unclear.
Nutthapong Kantrong +2 more
doaj +1 more source
From implantation to birth: insight into molecular melatonin functions [PDF]
, 2018 Melatonin is a lipophilic hormone synthesized and secreted mainly in the pineal gland, acting as a neuroendocrine transducer of photoperiodic information during the night.
Carlomagno, Gianfranco +3 more
core +1 more source