Results 41 to 50 of about 5,798 (220)
Comparison of melatonin with growth factors in promoting precursor cells proliferation in adult mouse subventricular zone [PDF]
, 2016 Melatonin, secreted mainly by the pineal gland, plays roles in various physiological functions including protecting cell death. We showed in previous study that the proliferation and differentiation of precursor cells from the adult mouse subventricular ...
Ekthuwapranee, Kasima +2 more
core +1 more source
Melatonin inhibits granulocyte adhesion to ICAM via MT3/QR2 and MT2 receptors [PDF]
International Immunology, 2015 AbstractNeutrophils are cells of the innate immune system that first respond and arrive to the site of infection. Melatonin modulates acute inflammatory responses by interfering with leukocyte recruitment. It is known that melatonin modulates granulocyte migration though the endothelial layer thereby acting on the endothelial cell. Here we investigated
Vitalij, Černyšiov +2 more
openaire +2 more sources
MT1 and MT2 melatonin receptors play opposite roles in brain cancer progression
Journal of Molecular Medicine, 2021 Primary brain tumors remain among the deadliest of all cancers. Glioma grade IV (glioblastoma), the most common and malignant type of brain cancer, is associated with a 5-year survival rate of
G. S. Kinker +11 more
openaire +3 more sources
Molecular Pain, 2023 Background Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, and its specific pathogenesis is still unclear. We have previously reported that TTX-resistant (TTX-R) sodium channels in colon-specific dorsal root ganglion (DRG)
Meng-Dan Lv +5 more
doaj +1 more source
Circadian rhythms and hormonal homeostasis: Pathophysiological implications [PDF]
, 2017 Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation ...
Bruscalupi, Giovannella, Gnocchi, Davide
core +2 more sources
In-vivo Thermal Stress Induces Melatonin Receptors and Heat Shock Proteins Expression in the Spleen of Mice in a Time and Temperature Dependent Manner [PDF]
Journal of Stress Physiology & Biochemistry, 2023 Heat shock proteins (Hsps) responses against stress conditions. Melatonin completes its stress relieving activities via its MT1 and MT2 receptors. The present study delineates the expression pattern of Hsp70/Hsc70 and MT1/MT2 receptor proteins along with
Samik Acharjee, Shiv Shankar Singh
doaj
Empowering Melatonin Therapeutics with Drosophila Models
Diseases, 2021 Melatonin functions as a central regulator of cell and organismal function as well as a neurohormone involved in several processes, e.g., the regulation of the circadian rhythm, sleep, aging, oxidative response, and more.
Cassandra Millet-Boureima +5 more
doaj +1 more source
N-(Phenoxyalkyl)amides as MT1 and MT2 ligands: Antioxidant properties and inhibition of Ca2+/CaM-dependent kinase II [PDF]
, 2013 Recently a series of chiral N-(phenoxyalkyl)amides have been reported as potent MT(1) and MT(2) melatonergic ligands. Some of these compounds were selected and tested for their antioxidant properties by measuring their reducing effect against oxidation ...
A. Carocci +11 more
core +1 more source
Human Gastroenteropancreatic Expression of Melatonin and Its Receptors MT1 and MT2
PLOS ONE, 2015 The largest source of melatonin, according to animal studies, is the gastrointestinal (GI) tract but this is not yet thoroughly characterized in humans. This study aims to map the expression of melatonin and its two receptors in human GI tract and pancreas using microarray analysis and immunohistochemistry.Gene expression data from normal intestine and
Söderquist, Fanny +2 more
openaire +5 more sources
AntioxidantsMelatonin, a well-known antioxidant, has been widely used in sperm cryopreservation of various animals, but its regulatory mechanism in fish remains unclear.
Yuxin Zhang +8 more
doaj +1 more source