Results 61 to 70 of about 5,798 (220)
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Regulation of bone mass through pineal‐derived melatonin‐
Journal of Pineal Research, 2017 AbstractTryptophan, an essential amino acid through a series of enzymatic reactions gives rise to various metabolites, viz. serotonin and melatonin, that regulate distinct biological functions. We show here that tryptophan metabolism in the pineal gland favors bone mass accrual through production of melatonin, a pineal‐derived neurohormone.
Kunal Sharan +3 more
openaire +4 more sources
Non-24-Hour Sleep-Wake Disorder Revisited – A Case Study [PDF]
, 2016 The human sleep-wake cycle is governed by two major factors: a homeostatic hourglass process (process S), which rises linearly during the day, and a circadian process C, which determines the timing of sleep in a ~24-h rhythm in accordance to the external
Bromundt, Vivien +6 more
core +6 more sources
Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells
Cellular & Molecular Biology Letters, 2019 Melatonin receptors MT1 and MT2 (genes officially named MTNR1A and MTNR1B, respectively) play crucial roles in melatonin-mediated regulation of circadian rhythms, the immune system, and control of reproduction in seasonally breeding animals.
Yuan Gao +9 more
doaj +1 more source
Antioxidants, 2022 Previous studies suggest that the inclusion of melatonin (MTn) in in vitro maturation protocols improves the developmental competence of oocytes by scavenging reactive oxygen species (ROS). However, the molecular mechanisms integrating melatonin receptor
Jun-Xue Jin +8 more
doaj +1 more source
The melatonergic system in mood and anxiety disorders and the role of agomelatine: implications for clinical practice [PDF]
, 2013 Melatonin exerts its actions through membrane MT1/MT2 melatonin receptors, which belong to the super family of G-protein-coupled receptors consisting of the typical seven transmembrane domains.
De Berardis D. +10 more
core +2 more sources
Effects of Agomelatine on Sleep Across Populations: A Systematic Review and Meta‐Analysis
Journal of Sleep Research, EarlyView.ABSTRACT Agomelatine, a melatoninergic antidepressant, is often prescribed to improve sleep disturbance, though meta‐analytic evidence is currently lacking. This systematic review and meta‐analysis assessed its efficacy and tolerability in sleep outcomes compared to placebo.
Anastasios Stefanou +7 more
wiley +1 more source
Modulation of human ovarian function by melatonin
Frontiers in Bioscience-Elite, 2020 Melatonin, a hormone which is primarily released by the pineal gland, has a wide range of actions in the female reproductive tract. While the melatonin receptor subtype, MT3, has been identified in amphibian animals and birds, in humans and other mammals,
Seema Rai, Hindole Gosh
doaj +1 more source
Cell Death and Disease, 2022 Progressive structural changes in osteoarthritis (OA) involve synovial inflammation and angiogenesis, as well as activation of the proinflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin (IL)-8, and the angiogenic factor vascular ...
Shan-Chi Liu +7 more
doaj +1 more source
PLoS Pathogens, 2023 Influenza A virus (IAV) H1N1 infection is a constant threat to human health and it remains so due to the lack of an effective treatment. Since melatonin is a potent antioxidant and anti-inflammatory molecule with anti-viral action, in the present study ...
Caiyun Huo +10 more
doaj +1 more source