Results 81 to 90 of about 5,798 (220)

Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer’s disease

European Journal of Histochemistry, 2009
The pineal hormone melatonin is involved in physiological transduction of temporal information from the light dark cycle to circadian and seasonal behavioural rhythms, as well as possessing neuroprotective properties.
P Brunner, N Sözer-Topcular, R Jockers, R Ravid, D Angeloni, F Fraschini   +5 more
doaj   +1 more source

Melatonin restores Muc2 depletion induced by V. vulnificus VvpM via melatonin receptor 2 coupling with Gαq

Journal of Biomedical Science, 2020
Background Melatonin (5-methoxy-N-acetyltryptamine), a hormone produced in the pineal gland, has a variety of biological functions as an antioxidant, but a functional role of melatonin in the regulation of intestinal mucin (Muc) production during ...
Young-Min Lee, Jong Pil Park, Young Hyun Jung, Hyun Jik Lee, Jun Sung Kim, Gee Euhn Choi, Ho Jae Han, Sei-Jung Lee   +7 more
doaj   +1 more source

The Impact of Melatonin and its Agonist on Endothelin-1 Reactivity in Isolated Aorta in Continuous Light and Pinealectomized Rats

Zanco Journal of Pure and Applied Sciences, 2023
   The purpose of the present study is to investigate the influence of melatonin and its receptor (MT1, and MT2) agonist (Ramelteon) on vascular endothelin-1 (ET-1) reactivity in isolated aortic rings in continuous light emitting diode (LED) exposure ...
Evan B. Othman, Ismail M. Maulood
doaj   +1 more source

Novas diretrizes no diagnóstico e tratamento das insônias [PDF]

, 2010
The Brazilian Sleep Association brought together specialists in sleep medicine, in order to develop new guidelines on the diagnosis and treatment of insomnias.
Alves, Rosana Cardoso, Alóe, Flávio, Araújo, John Fontenelle, Assis, Márcia, Ataíde Júnior, Luiz, Bacellar, Andrea, Bittencourt, Lia Rita, Caixeta, Eliazor, Fonseca, Ronaldo, Hasan, Rosa, Minhoto, Gisele, Pinto Júnior, Luciano Ribeiro, Pinto, Maria Christina Ribeiro, Poyares, Dalva, Pradella-Hallinan, Márcia Lurdes de Cacia, Rizzo, Geraldo, Rodrigues, Raimundo Nonato Delgado, Tavares, Stella   +17 more
core   +4 more sources

Gestational Melatonin Supplementation Attenuates Maternal Sleep Deprivation‐Induced Steatohepatitis Susceptibility in Offspring

Cell Proliferation, Volume 59, Issue 5, May 2026.
Maternal SD during pregnancy enhances the development of diet‐induced NASH in adult offspring of both sexes through an NR4A3‐dependent mechanism, characterised by heightened inflammation and increased apoptosis. Maternal melatonin supplementation effectively alleviates this increased susceptibility to NASH in offspring.
Fei Guo, Zexin Yang, Junsen She, Chen Fang, Yizhi Hu, Hefeng Huang, Ling Gao   +6 more
wiley   +1 more source

Melatonergic Signaling Sustains Food Allergy Through FcεRI Recycling

Research
The prevalence of food allergies is increasing dramatically and causing serious public health concerns. Notably, melatonin metabolism imbalance in patients with food allergies; however, the role of melatonin in food allergies remains unclear.
Youxia Wang, Xinmei Zhang, Ifen Hung, Chunxue Liu, Wenkai Ren, Liangpeng Ge, Hao Wang   +6 more
doaj   +1 more source

Melatonin and Human Cardiovascular Disease [PDF]

, 2016
The possible therapeutic role of melatonin in the pathophysiology of coronary artery disorder (CAD) is increasingly being recognized. In humans, exogenous melatonin has been shown to decrease nocturnal hypertension, improve systolic and diastolic blood ...
Akinseye, Oluwaseun A., BaHammam, Ahmed S., Brown, Gregory M., Buttoo, Kenneth, Cardinali, Daniel Pedro, Dhandapany, Perundurai S., Kendzerska, Tetyana, Ojike, Nwakile I., Pandi Perumal, Seithikurippu R.   +8 more
core   +2 more sources

The Potential Functions and Beneficial Effects of Melatonin on Cognitive Impairment, Neuroinflammation, Blood–Brain Barrier Leakage, and Synaptic Dysfunction in the Offspring of Mice Exposed to Gestational Intermittent Hypoxia

Brain and Behavior, Volume 16, Issue 4, April 2026.
Melatonin rescues the cognitive deficits induced by gestational intermittent hypoxia exposure in male offspring mice, and these results were associated with neuroinflammation, BBB integrity, and alterations in synaptic function. ABSTRACT Introduction Gestational intermittent hypoxia (GIH), which serves as a model for obstructive sleep apnea (OSA), is ...
Xue‐Yan Li, Yun‐Zhoug Cheng, Yue‐Ming Zhang, Fei Hu, Shi‐Kun Fang, Gui‐Hai Chen, Yu Wang   +6 more
wiley   +1 more source

Gene and protein patterns of potential prion-related markers in the central nervous system of clinical and preclinical infected sheep [PDF]

, 2013
The molecular pathogenic mechanisms of prion diseases are far from clear. Genomic analyses have revealed genetic biomarkers potentially involved in prion neuropathology in naturally scrapie-infected sheep, a good animal model of infectious prionopathies.
Antonia Vargas, Enric Vidal, Filali, Hicham, Hicham Filali, Inmaculada Martin-Burriel, Juan J Badiola, Martí Pumarola, Mercedes Márquez, Paola Marco, Rosa Bolea   +9 more
core   +4 more sources

The role of agomelatine in appetite regulation and body weight in rats

Experimental Physiology, Volume 111, Issue 4, Page 1808-1818, 1 April 2026.
Abstract The hypothalamic nuclei play a central role in the synthesis of anorexigenic and orexigenic neuropeptides, which are regulated by peripheral hormones, like leptin and ghrelin. Melatonergic receptors (MT1/MT2) are prominently expressed in the arcuate nucleus of the hypothalamus – an essential hub for appetite control – and in peripheral ...
Engin Korkmaz, Yavuz Erden, Çiğdem Tekin, Suat Tekin   +3 more
wiley   +1 more source