Results 91 to 100 of about 5,798 (220)
Neural stem cells express melatonin receptors and neurotrophic factors: colocalization of the MTreceptor with neuronal and glial markers [PDF]
Background In order to optimize the potential benefits of neural stem cell (NSC) transplantation for the treatment of neurodegenerative disorders, it is necessary to understand their biological characteristics.
McMillan Catherine R +7 more
core +1 more source
ABSTRACT Smith‐Magenis Syndrome (SMS) is an uncommon genetic disorder caused by microdeletions of chromosome 17p11.2 including the RAI1 gene, or loss‐of‐function mutations that directly affect RAI1. Due to the involvement of RAI1 in neurodevelopment, SMS leads to typical pathologic features in the behavioral and physical phenotype that must be ...
Edgar Andrés Chavarría‐Martínez +4 more
wiley +1 more source
Anti-oxidants in Parkinson's disease therapy: a critical point of view [PDF]
Parkinson's disease (PD) is a degenerative neurological syndrome, which is characterized by the preferential death of dopaminergic (DAergic) neurons in the SubstantiaNigra.
Beltramini, Mariano +3 more
core +2 more sources
Abstract Aim Children with autism spectrum disorder (ASD) are more likely to have sleep problems. Few studies have investigated the relationship between sleep problems and blood melatonin and ferritin levels. The objective of this study was to determine the correlation between sleep problems and morning serum melatonin and ferritin levels, and the ...
Ai Terui +7 more
wiley +1 more source
Ultrastructural evidence of a secretory role for melatonin in the human parotid gland [PDF]
In vivo animal studies show that pentagastrin, cholecystokinin and melatonin cause the secretion and synthesis of salivary proteins. Melatonin occurs in large amounts in the gut and is released into the blood on food intake.
Ekstrom, J. +6 more
core
Switching from serotonin reuptake inhibitors to agomelatine in patients with refractory obsessive-compulsive disorder: a 3 month follow-up case series [PDF]
Serotonin reuptake inhibitors (SRIs) currently represent the cornerstone of obsessive-compulsive disorder (OCD) pharmacotherapy. However, OCD is characterized by high rates of partial and/or absent response to standard, recommended treatments, often ...
Michele Fornaro
core +2 more sources
Sleep quality and sleepiness in adults with multiple myeloma. Is melatonin a potential treatment?
Abstract Sleep disturbances significantly impact quality of life in cancer patients, yet remain poorly characterized in multiple myeloma (MM). This observational study aimed to characterize sleep profiles in MM patients and evaluate the therapeutic potential of exogenous melatonin.
Mariana Fiori +5 more
wiley +1 more source
BackgroundMelatonin modulates circadian rhythms in physiology and sleep initiation. Genetic variants of the MTNR1B locus, encoding the melatonin MT2 receptor, have been associated with increased type 2 diabetes (T2D) risk. Carriers of the common intronic
Akram Imam +17 more
doaj +1 more source
Molecular mechanisms of the sleep wake cycle : therapeutic applications to insomnia [PDF]
The aim of this review is to explore the molecular mechanism and genetic components of the sleepwake cycle and insomnia. Moreover, we wanted to review the correlation between primary insomnia and its comorbidities.
Grima, Melanie +2 more
core +1 more source

