Results 111 to 120 of about 5,798 (220)

A Review of Melatonin, Its Receptors and Drugs

Eurasian Journal of Medicine, 2019
After a Turkish scientist took Nobel Prize due to his contributions to understand clock genes, melatonin, closely related to these genes, may begin to shine.
Mucahit Emet, Halil Ozcan, Lutfu Ozel, Muhammed Yayla, Zekai Halici, Ahmet Hacimuftuoglu   +5 more
doaj   +1 more source

Melatonin MT1 and MT2 receptor expression in Parkinson's disease.

Medical science monitor : international medical journal of experimental and clinical research, 2010
Idiopathic Parkinson disease (PD) is a multi-system disorder with a multifactorial etiology and diverse clinical phenotype. Selective, regional dopaminergic neuronal degeneration in the substantia nigra and other CNS areas including the amygdala are observed in all patients.
Nikhil, Adi, Deborah C, Mash, Yousuf, Ali, Carlos, Singer, Lina, Shehadeh, Spyridon, Papapetropoulos   +5 more
openaire   +1 more source

Potential pleiotropic beneficial effects of adjuvant melatonergic treatment in posttraumatic stress disorder [PDF]

, 2016
Loss of circadian rhythmicity fundamentally affects the neuroendocrine, immune and autonomic system, similar to chronic stress and may play a central role in the development of stress-related disorders.
Agorastos, Agorastos, Linthorst, Astrid C E   +1 more
core   +2 more sources

The Effect of Melatonin on Behavioral, Molecular, and Histopathological Changes in Cuprizone Model of Demyelination [PDF]

, 2016
Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system. The protective effects of melatonin (MLT) on various neurodegenerative diseases, including MS, have been suggested.
Ghadiri, T., Ghaemi, A., Gorji, A., Khodagholi, F., Noorbakhsh, F., Sharifzadeh, M., Vakilzadeh, G.   +6 more
core  

Functional insights into modulation of BKCa channel activity to alter myometrial contractility [PDF]

, 2014
The large-conductance voltage- and Ca2+-activated K+ channel (BKCa) is an important regulator of membrane excitability in a wide variety of cells and tissues.
England, Sarah K, Lorca, Ramón A, Prabagaran, Monali   +2 more
core   +3 more sources

Compuestos neurogénicos basados en melatonina y su uso en el tratamiento de enfermedades del sistema nervioso [PDF]

, 2013
La presente invención, que se incluye en el campo de la investigación e industria farmacéutica, se refiere a nuevas entidades químicas derivadas de melatonina con propiedades neurogénicas, moduladoras de los receptores de melatonina y/o ...
Alonso-Gil, Sandra, Fuente Revenga, Mario de la, Morales-García, José A., Pérez Castillo, Ana, Pérez Martín, María Concepción, Rodríguez-Franco, María Isabel   +5 more
core  

MT1/MT2 melatonin receptors in proinflammatory T helper cell populations

Russian Journal of Immunology
Melatonin, a pineal gland hormone, is an effective regulator of the main T helper Th1 and Th17 populations. Currently, the studies of T helpers are shifting from classical to non-classical variants of these cells, primarily to Th1-polarized Th17 lymphocytes (Th17.1), which are formed in vitro and in vivo by transformation of differentiated Th17 cells ...
Elena M. Kuklina, Irina Y. Danchenko, Tatiana V. Baidina   +2 more
openaire   +1 more source

Melatonin regulates mitochondrial function to alleviate ferroptosis through the MT2/Akt signaling pathway in swine testicular cells

Scientific Reports
Increasing evidence has shown that many environmental and toxic factors can cause testicular damage, leading to testicular ferroptosis and subsequent male reproductive disorders.
Yuanjie Zhao, Ge Qin, Biao Jiang, Jinglei Huang, Shiwen He, Hui Peng   +5 more
doaj   +1 more source

Melatonin alleviates aging-related heart failure through melatonin receptor 1A/B knockout in mice

Heliyon
Age-related cardiovascular diseases continue to be important issues that contribute to the societal burden. Unveiling the molecular mechanisms underlying age-related cardiovascular diseases provides novel opportunities to delay aging and facilitate early
Zhenyu Feng, Yang Liu, Yijin Yang, Jie Bai, Qiu-yue Lin, Yun-long Xia, Yunpeng Xie   +6 more
doaj   +1 more source

Estudios básicos y clínicos sobre la melatonina como ejemplo de medicina traslacional [PDF]

, 2015
A esta altura de la vida uno se siente tentado a detenerse y reflexionar sobre lo que la vida profesional le ha deparado. En mi caso se cumplen 50 años de mi relación con la glándula pineal y la melatonina y reconozco la inmensa fortuna de haberme ...
Cardinali, Daniel Pedro
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