Results 71 to 80 of about 5,798 (220)
Aging Cell, Volume 25, Issue 5, May 2026.Melatonin restores testosterone production in aging Leydig cells by targeting key pathological drivers, particularly oxidative stress and mitochondrial dysfunction. This approach offers a fundamental strategy to reshape the Late‐onset hypogonadism treatment paradigm.
Hui Wu +6 more
wiley +1 more source
Melatonin MT1 and MT2 Receptors in the Ram Reproductive Tract [PDF]
International Journal of Molecular Sciences, 2017 Some melatonin functions in mammals are exerted through MT1 and MT2 receptors. However, there are no reports of their presence in the reproductive tract of the ram, a seasonal species. Thus, we have investigated their existence in the ram testis, epididymis, accessory glands and ductus deferens.
Marta González-Arto +11 more
openaire +2 more sources
Frontiers in PharmacologyObjectivesDim light at night contributes to neurodegenerative diseases by causing neuroinflammation. In the central nervous system, the activation of microglia is a significant contributor to neuroinflammation.
Chao Song +5 more
doaj +1 more source
The potential anti-cancer effects of melatonin on breast cancer
Exploration of Medicine, 2022 Melatonin is the primary hormone of the pineal gland that is secreted at night. It regulates many physiological functions, including the sleep-wake cycle, gonadal activity, free radical scavenging, immunomodulation, neuro-protection, and cancer ...
Naba Kumar Das, Saptadip Samanta
doaj +1 more source
Dynamics of the melatonin MT1 receptor in the rat parotid gland upon melatonin administration [PDF]
, 2016 Our recent ultrastructural study of human parotid glands revealed that the melatonin receptors, MT1 and MT2, are localised in the plasma cell membranes of acinar and ductal cells but also, and intriguingly, predominantly in acinar secretory granules ...
Ekstrom, J +4 more
core
Remodeling Of The Bone Tissue Of Rats Of Different Lines After Melatonin Effect [PDF]
, 2016 The markers of remodeling of bone tissue (BT) were studied after the impact of pharmacologic dose of melatonin (5 mg/kg of the animal body weight) during 28 days for 3-months rats-males of Wistar and SHR lines.
Berezovskyi, V. (Vadim) +2 more
core +2 more sources
T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets
Aging Cell, Volume 25, Issue 5, May 2026.Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu +3 more
wiley +1 more source
Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway [PDF]
Sirtuin1 (SIRT1) and forkhead box transcription factor O subfamily 1 (FOXO1) play vital roles in the maintenance of hippocampal neuronal homeostasis during aging. Our previous study showed that melatonin, a hormone mainly secreted by the pineal gland,
Boontem, Parichart +5 more
core +1 more source
Acta Psychiatrica Scandinavica, Volume 153, Issue 5, Page 402-431, May 2026.ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian +3 more
wiley +1 more source
Drug Design, Development and Therapy, 2020 Jinjing Wu,* Yanli Yang,* Yafen Gao, Zhaoqi Wang, Jun Ma Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University-Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, People’s Republic of China*These authors ...
Wu J, Yang Y, Gao Y, Wang Z, Ma J
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