Results 51 to 60 of about 5,798 (220)
Sites of action of sleep and wake drugs: insights from model organisms [PDF]
, 2013 Small molecules have been used since antiquity to regulate our sleep. Despite the explosion of diverse drugs to treat problems of too much or too little sleep, the detailed mechanisms of action and especially the neuronal targets by which these compounds
Rihel, J, Schier, AF
core +1 more source
Improving Melatonin Delivery Within the Eye [PDF]
, 2017 Melatonin is a neurohormone synthesized in the pineal gland as well as in other organs and it plays an important role in many ocular functions, as it is synthesized in numerous eye structures.
Alkozi, Hanan Awad, Pintor, Jesús
core +2 more sources
Comment développer un antidépresseur au mécanisme d’action innovant : l’exemple de l’agomélatine [PDF]
, 2005 Divers axes de recherche ont été suivis pour obtenir de nouveaux traitements de la dépression plus efficaces, mieux tolérés et d’action plus rapide. Parmi ces axes de recherche, la mélatonine, synchronisateur endogène des rythmes biologiques chez les ...
Boyer, Pierre-Alain +3 more
core +1 more source
Absence seizures: Update on signaling mechanisms and networks
Epilepsia Open, EarlyView.Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley +1 more source
Медицинская иммунология, 2023 The hormone melatonin is involved in regulation of functioning of almost all organs and systems of the organism. In the immune system, T lymphocytes are an important target of melatonin: they express specific melatonin receptors with different affinities
N. S. Glebezdina +2 more
doaj +1 more source
The role of the mammalian prion protein in the control of sleep [PDF]
, 2017 Sleep disruption is a prevalent clinical feature in many neurodegenerative disorders, including human prion diseases where it can be the defining dysfunction, as in the case of the “eponymous” fatal familial insomnia, or an early-stage symptom as in ...
Gill, Andrew C., Roguski, Amber
core +2 more sources
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang +4 more
wiley +1 more source
Structure-based discovery of potent and selective melatonin receptor agonists
eLife, 2020 Melatonin receptors MT1 and MT2 are involved in synchronizing circadian rhythms and are important targets for treating sleep and mood disorders, type-2 diabetes and cancer.
Nilkanth Patel +8 more
doaj +1 more source
New quinoxaline derivatives as potential MT₁ and MT₂ receptor ligands. [PDF]
, 2012 Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable ...
Aldana, I. (Ignacio) +7 more
core
The role and therapeutic potential of melatonin in age-related ocular diseases [PDF]
, 2017 The eye is continuously exposed to solar UV radiation and pollutants, making it prone to oxidative attacks. In fact, oxidative damage is a major cause of age-related ocular diseases including cataract, glaucoma, age-related macular degeneration and ...
Colligris, Basilio +3 more
core +2 more sources