Results 11 to 20 of about 5,798 (220)

MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations [PDF]

Journal of Pineal Research, 2019
AbstractMelatonin (MLT) exerts its physiological effects principally through two high‐affinity membrane receptors MT1 and MT2. Understanding the exact mechanism of MLT action necessitates the use of highly selective agonists/antagonists to stimulate/inhibit a given MLT receptor. The respective distribution of MT1 and MT2 within the CNS and elsewhere is
Klosen, Paul, Lapmanee, Sarawut, Schuster, Carole, Guardiola, Béatrice, Hicks, David, Pevet, Paul, Felder‐schmittbuhl, Marie Paule   +6 more
openaire   +5 more sources

Melatonin inhibits muscular-mucosal stretch-sensitive bladder afferents via the MT2 receptors

Scientific Reports, 2022
Melatonin is a circadian rhythm regulator capable of controlling a variety of physiological processes in the body. It predominantly acts via the melatonin 1 (MT1) and MT2 receptors expressed in the CNS neurons and peripheral organs and tissues. Melatonin
Stewart Ramsay, Vladimir Zagorodnyuk
doaj   +4 more sources

Melatonin signaling in mouse cerebellar granule cells with variable native MT1 and MT2 melatonin receptors [PDF]

Brain Research, 2008
Although G protein-coupled MT1 and MT2 melatonin receptors are expressed in neurons of the mammalian brain including in humans, relatively little is known about the influence of native MT1 and MT2 melatonin receptors on neuronal melatonin signaling. Whereas human cerebellar granule cells (CGC) express only MT1 receptors, mouse CGC express both MT1 and ...
IMBESI, MARTA, UZ T, DZITOYEVA S, GIUSTI, PIETRO, MANEV H.   +4 more
openaire   +4 more sources

Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep

Frontiers in Endocrinology, 2019
The pathophysiological function of the G-protein coupled melatonin MT1 and MT2 receptors has not yet been well-clarified. Recent advancements using selective MT1/ MT2 receptor ligands and MT1/MT2 receptor knockout mice have suggested that the activation ...
Gabriella Gobbi, Stefano Comai, Stefano Comai   +2 more
doaj   +3 more sources

Functional Expression of MT2 (Mel1b) Melatonin Receptors in Human PAZ6 Adipocytes [PDF]

Endocrinology, 2001
Several reports have demonstrated that the pineal hormone, melatonin, plays an important role in body mass regulation in mammals. To date, however, the target tissues and relevant biochemical mechanisms involved remain uncharacterized. As adipose tissue is the principal site of energy storage in the body, we investigated whether melatonin could also ...
L, Brydon, L, Petit, P, Delagrange, A D, Strosberg, R, Jockers   +4 more
openaire   +3 more sources

The genomic response of human granulosa cells (KGN) to melatonin and specific agonists/antagonists to the melatonin receptors

Scientific Reports, 2022
Melatonin is a known modulator of follicle development; it acts through several molecular cascades via binding to its two specific receptors MT1 and MT2. Even though it is believed that melatonin can modulate granulosa cell (GC) functions, there is still
Asma Arjoune, Marc-André Sirard
doaj   +1 more source

Anti-Inflammatory Effects of Melatonin in Rats with Induced Type 2 Diabetes Mellitus

Life, 2022
Introduction: Insulin resistance is associated with a pro-inflammatory state increasing the risk for complications in patients with type 2 diabetes mellitus (T2DM).
Hande Yapislar, Ebru Haciosmanoglu, Turkan Sarioglu, Sevgin Degirmencioglu, Ibrahim Sogut, Michael Poteser, Cem Ekmekcioglu   +6 more
doaj   +1 more source

Synthesis and functional characterization of substituted isoquinolinones as MT2-selective melatoninergic ligands. [PDF]

PLoS ONE, 2014
A series of substituted isoquinolinones were synthesized and their binding affinities and functional activities towards human melatonin MT1 and MT2 receptors were evaluated.
Yueqing Hu, King H Chan, Xixin He, Maurice K C Ho, Yung H Wong   +4 more
doaj   +1 more source

Melatonin Receptors: A Key Mediator in Animal Reproduction

Veterinary Sciences, 2022
Melatonin, a hormone produced by the mammalian pineal gland, influences various physiological activities, many of which are related to animal reproduction, including neuroendocrine function, rhythm regulation, seasonal behavior, gonadogenesis, gamete ...
Yuan Gao, Shuqin Zhao, Yong Zhang, Quanwei Zhang   +3 more
doaj   +1 more source

The ubiquitin-specific protease 8 antagonizes melatonin-induced endocytic degradation of MT1 receptor to promote lung adenocarcinoma growth

Journal of Advanced Research, 2022
Introduction: The human genome encodes two melatonin receptors (MT1 and MT2) that relay melatonin signals to cellular interior. Accumulating evidence has linked melatonin to multiple health benefits, among which its anticancer effects have become well ...
Qianhui Sun, Jinrui Zhang, Xiaoxi Li, Guoheng Yang, Shaoxuan Cheng, Dong Guo, Qingqing Zhang, Feng Sun, Feng Zhao, Dian Yang, Shanshan Wang, Taishu Wang, Shuyan Liu, Lijuan Zou, Yingqiu Zhang, Han Liu   +15 more
doaj   +1 more source