Results 191 to 200 of about 5,798 (220)

Functional MT1 and MT2 melatonin receptors in mammals.

Endocrine, 2005
Melatonin, dubbed the hormone of darkness, is known to regulate a wide variety of physiological processes in mammals. This review describes well-defined functional responses mediated through activation of high-affinity MT1 and MT2 G protein-coupled receptors viewed as potential targets for drug discovery.
Margarita L, Dubocovich, Magdalena, Markowska   +1 more
openaire   +1 more source

Human amniotic epithelial cells express melatonin receptor MT1, but not melatonin receptor MT2: a new perspective to neuroprotection.

Journal of pineal research, 2011
Recent studies have demonstrated that the human placenta is a novel source of adult stem cells. We have provided laboratory evidence that transplantation of these human placenta-derived cells in vitro and in vivo stroke models promotes functional recovery.
Kaneko, Yuji, Hayashi, Takuro, Yu, Seongjin, Tajiri, Naoki, Bae, Eunkyung C, Solomita, Marianna A, Chheda, Sonia H, Weinbren, Nathan L, Parolini, Ornella, Borlongan, Cesar V.   +9 more
openaire   +2 more sources

Molecular pharmacology of the ovine melatonin receptor: comparison with recombinant human MT1 and MT2 receptors

Biochemical Pharmacology, 2004
The variations of the pharmacological properties of melatonin receptors between different mammalian species in transfected cell lines have been poorly investigated. In the present study, melatonin analogues have been used to characterize the pharmacology of the recombinant ovine melatonin receptor (oMT1) expressed in CHO cell lines and the native oMT1 ...
Mailliet, F., Audinot, V., Malpaux, Benoit, Bonnaud, Anthony, Delagrange, P., Migaud, Martine, Barrett, P., Viaud-Massuard, M.C., Lesieur, D., Lefoulon, F., Renard, P., Boutin, Jany   +11 more
openaire   +2 more sources

Expression of melatonin (MT1, MT2) and melatonin-related receptors in the adult rat testes and during development

Zygote, 2010
SummaryIt is well known that melatonin provokes reproductive alterations in response to changes in hours of daylight in seasonally breeding mammals, exerting a regulatory role at different levels of the hypothalamic–pituitary–gonadal axis. Although it has also been demonstrated that melatonin may affect testicular activity in vertebrates, until now ...
IZZO G., ANIELLO F., FERRARA D., CAMPITIELLO M. R., SERINO, Ismene, MINUCCI, Sergio, D'ISTRIA M.   +6 more
openaire   +4 more sources

Selective MT2 melatonin receptor antagonist blocks melatonin-induced antinociception in rats

Neuroscience Letters, 2000
The present study was undertaken to assess the effects of intracerebroventricular (i.c.v.) luzindole (a selective MT(2) melatonin receptor antagonist) and prazosin (a selective MT(3) melatonin receptor antagonist) on melatonin-induced antinociception, so as to clarify which of melatonin receptor subtypes within the central nervous system (CNS) was ...
C X, Yu, C B, Zhu, S F, Xu, X D, Cao, G C, Wu   +4 more
openaire   +2 more sources

MT2 selective melatonin receptor antagonists: design and structure-activity relationships

2005
Second Joint Italian-Swiss Meeting on Medicinal Chemistry Poster SC-15 -
RIVARA S, MOR M, LORENZI S, LODOLA A, PLAZZI PV, SPADONI, GILBERTO, BEDINI, ANNALIDA, TARZIA, GIORGIO   +7 more
openaire   +2 more sources

[Involvement of melatonin MT2 receptor mutants in type 2 diabetes development].

Medecine sciences : M/S, 2013
Genetic and environmental factors participate in the development of type 2 diabetes (T2D). Genome-wide association studies have revealed new genetic variants associated with T2D, including the rs10830963 variant located in the intron of the MTNR1B gene.
Angeliki, Karamitri, Monique, Vincens, Min, Chen, Ralf, Jockers   +3 more
openaire   +1 more source

Melatonin Receptor MT1 and MT2

2016
Atsuro Oishi, Ralf Jockers
openaire   +1 more source

QSAR and 3D-QSAR characterization of MT2-selective melatonin receptor antagonists

2001
HUNGARIAN-GERMAN-ITALIAN-POLISH JOINT MEETING ON MEDICINAL ...
RIVARA S., MOR M., SPADONI, GILBERTO, TARZIA, GIORGIO, VACONDIO F., LUCINI V., PLAZZI P. V.   +6 more
openaire   +1 more source

Melatonin Receptor MT2

2018
openaire   +1 more source