Results 21 to 30 of about 3,161 (162)
Melatonin Inhibits NF-κB/CREB/Runx2 Signaling and Alleviates Aortic Valve Calcification
Frontiers in Cardiovascular Medicine, 2022 Calcific aortic valve disease (CAVD) is linked to high mortality. Melatonin inhibits nuclear factor-kappa B (NF-κB)/cyclic AMP response element-binding protein (CREB), contributing to CAVD progression.
Shao-Jung Li +20 more
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Melatonin antagonizes lipopolysaccharide-induced pulpal fibroblast responses
BMC Oral Health, 2020 Background Pulpal inflammation is known to be mediated by multiple signaling pathways. However, whether melatonin plays regulatory roles in pulpal inflammation remains unclear.
Nutthapong Kantrong +2 more
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MT2 selective melatonin receptor antagonists: design and structure-activity relationships [PDF]
Arkivoc, 2006 The neurohormone melatonin is involved in the regulation of many physiological functions, in particular those related to circadian and seasonal rhythms. In mammals, melatonin activates two GPCRs, named MT1 and MT2, and ligands of these receptors have been proposed for the treatment of different pathologies.
RIVARA, Silvia +6 more
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Circadian Pattern of Melatonin MT1 and MT2 Receptor Localization in the Rat Suprachiasmatic Nucleus
Journal of Circadian Rhythms, 2015 The suprachiasmatic nucleus (SCN) is the circadian pacemaker. The pineal hormone melatonin is involved in the regulation of circadian phase. As a part of the circadian system its synthesis and secretion is under SCN control.
Nermien Waly, Richard Hallworth
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Melatonin signaling in mouse cerebellar granule cells with variable native MT1 and MT2 melatonin receptors [PDF]
Brain Research, 2008 Although G protein-coupled MT1 and MT2 melatonin receptors are expressed in neurons of the mammalian brain including in humans, relatively little is known about the influence of native MT1 and MT2 melatonin receptors on neuronal melatonin signaling. Whereas human cerebellar granule cells (CGC) express only MT1 receptors, mouse CGC express both MT1 and ...
IMBESI, MARTA +4 more
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Frontiers in Pharmacology, 2021 Objectives: Memory decline caused by insufficient sleep is a critical public health issues and currently lacks effective treatments. This study objective was to explore alleviative effect of melatonin on sleep deprivation (SD)-induced deficiencies in ...
Xintong Wang +4 more
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Heteromeric MT 1 /MT 2 Melatonin Receptors Modulate Photoreceptor Function [PDF]
Science Signaling, 2013 Melatonin stimulates a heteromeric G protein–coupled receptor to modulate the eye’s response to light flashes at night.
Baba, Kenkichi +11 more
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Frontiers in Cell and Developmental Biology, 2021 Although heterotopic ossification (HO) has been reported to be a common complication of the posttraumatic healing process, the underlying mechanism remains unknown.
Jie Zhang +14 more
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Reproductive Biology and Endocrinology, 2019 Background Melatonin is an amine hormone that plays an important role in regulating mammalian reproduction. This study aimed to investigate the expression pattern of melatonin synthesis enzymes AANAT and HIOMT and melatonin receptors MT1 and MT2 in sheep
Longfei Xiao +8 more
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Scientific Reports, 2017 Understanding the function of orphan G protein-coupled receptors (GPCRs), whose cognate ligand is unknown, is of major importance as GPCRs are privileged drug targets for many diseases. Recent phylogenetic studies classified three orphan receptors, GPR61,
Atsuro Oishi +5 more
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