Results 101 to 110 of about 18,237 (210)

Direct modulation of TRPC ion channels by Gα proteins

Frontiers in Physiology
GPCR-Gi protein pathways are involved in the regulation of vagus muscarinic pathway under physiological conditions and are closely associated with the regulation of internal visceral organs.
Hana Kang, Jinhyeong Kim, Christine Haewon Park, Byeongseok Jeong, Insuk So   +4 more
doaj   +1 more source

The guinea pig ileum lacks the direct, high-potency, M2-muscarinic, contractile mechanism characteristic of the mouse ileum [PDF]

, 2009
We explored whether the M2 muscarinic receptor in the guinea pig ileum elicits a highly potent, direct-contractile response, like that from the M3 muscarinic receptor knockout mouse.
AF Roffel, B Ringdahl, EA Thomas, EA Thomas, EA Thomas, EE Esqueda, FJ Ehlert, FJ Ehlert, FJ Ehlert, Frederick J. Ehlert, GT Bolger, GW Sawyer, JA Tran, L Noronha-Blob, LM Candell, M Matsui, M Matsui, MI Kotlikoff, Michael T. Griffin, Minoru Matsui, MT Griffin, MT Griffin, O Arunlakshana, R Inoue, RB Barlow, RB Barlow, Rennolds S. Ostrom, RM Eglen, RS Ostrom, RS Ostrom, T Kitazawa, T Sakamoto, T Unno, TB Bolton   +33 more
core   +4 more sources

Activation of M3 Muscarinic Acetylcholine Receptors Delayed Cardiac Aging by Inhibiting the Caspase-1/IL-1β Signaling Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Because the prevalence of age-related cardiac impairment increases as the human lifespan increases, it is important to combat the effects of aging.
Shu Wang, Yanan Jiang, Jingling Chen, Changliang Dai, Dandan Liu, Wei Pan, Lijuan Wang, Moyondafoluwa Blessing Fasae, Lihua Sun, Lanfeng  Wang, Yan Liu   +10 more
doaj   +1 more source

Regulation of human oligodendrocyte differentiation by muscarinic M3 receptor

The FASEB Journal, 2012
Oligodendrocytes are destroyed in demyelinating diseases such as Multiple Sclerosis. In a genomic study to identify novel drug targets, we identified the muscarinic cholinergic M3 receptor as highly expressed by human oligodendrocyte progenitor cells (OPCs).
Bansi H. Vedia, Suyog Pol, Melanie A. O'Bara, Fraser J. Sim   +3 more
openaire   +1 more source

Novel aspects of cholinergic regulation of colonic ion transport [PDF]

, 2015
Nicotinic receptors are not only expressed by excitable tissues, but have been identified in various epithelia. One aim of this study was to investigate the expression of nicotinic receptors and their involvement in the regulation of ion transport across
Bader, Sandra, Diener, Martin
core   +1 more source

Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways

British Journal of Pharmacology, Volume 182, Issue 17, Page 4122-4133, September 2025.
Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani, Clive Page, Francesco Facciolo, Mia Lundblad, Luigino Calzetta   +4 more
wiley   +1 more source

The Role of Muscarinic Acetylcholine Receptor M3 in Cardiovascular Diseases

International Journal of Molecular Sciences
The muscarinic acetylcholine receptor M3 (M3-mAChR) is involved in various physiological and pathological processes. Owing to specific cardioprotective effects, M3-mAChR is an ideal diagnostic and therapeutic biomarker for cardiovascular diseases (CVDs).
xinxing liu, Yi Yu, Haiying Zhang, min zhang, yan liu   +4 more
openaire   +2 more sources

Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning [PDF]

, 2016
This work was supported by the British Heart Foundation (Ref: RG/14/4/30736), Medical Research Council (MR/N02589X/1) and The Wellcome Trust (Ref: 200893/Z/16/Z). A.V.G. is a Wellcome Trust Senior Research Fellow. S.M.
Aleksander Mrochek, Alexander V. Gourine, Ana Gutierrez del Arroyo, Andrey Gourine, Barragán, Gareth L. Ackland, Gourine, Göke, Jenifer Sanchez, John Pernow, Marina V. Basalay, Per-Ove Sjoquist, Svetlana Mastitskaya, Uitterdijk   +13 more
core   +2 more sources

Management of COPD With Cardiovascular Risk in Asia: A Review by the Asian Pacific Society of Respirology COPD Assembly

Respirology, Volume 30, Issue 9, Page 817-830, September 2025.
ABSTRACT Chronic obstructive pulmonary disease (COPD) has a high burden in Asia. These patients are also susceptible to various cardiovascular diseases (CVD). A panel of expert Asian pulmonologists explored the published literature to understand the impact of COPD and CVD on each other and to identify the cardiopulmonary risk factors in the region. The
Chin Kook Rhee, Fanny Wai San Ko, Vu Van Giap, Theerasuk Kawamatawong, Jung‐Kyu Lee, Kazuto Matsunaga, Helmy Haja Mydin, Yong‐Kek Pang, Diahn‐Warng Perng, Myla Salazar‐Supe, Yoko Shibata, David Sim, Naoya Tanabe, Augustine Tee, Hao‐Chien Wang, Yen‐Wen Wu, Faisal Yunus   +16 more
wiley   +1 more source

Characterization of a Muscarinic M3 Receptor‐Associated Protein Complex

The FASEB Journal, 2011
A receptor and its cognate G protein may be pre‐coupled in the absence of agonist. Here, we address whether a) the muscarinic M3 receptor (M3R) is pre‐assembled with G proteins, and b) whether other G protein‐binding signaling molecules are present in this complex.
Wei Kan, Alan V. Smrcka, Stephen M. Lanier   +2 more
openaire   +2 more sources