Results 81 to 90 of about 1,546 (109)

Identification of m3, m4 and m5 subtypes of muscarinic receptor mRNA in human blood mononuclear cells

, 1995
In this study we made use of the Reverse transcription-polymerase chain reaction to analyze the expression of mRNA for the five subtypes of muscarinic acetylcholine receptors in human blood mononuclear cells. mRNA for m3, m4 and m5 subtypes was detected,
Costa, L. G., Costa, P, Traver, D. J, Auger, C. B   +3 more
core  

Comparison of selective M3 and nonselective muscarinic receptor antagonists on gastrointestinal transit and bowel habits in humans

, 2010
M3 and nonselective muscarinic receptor antagonists on gastrointes-tinal transit and bowel habits in humans. Am J Physiol Gastrointest Liver Physiol 299: G215–G219, 2010.
Karthik Ravi, Adil E. Bharucha, Alan R. Zinsmeister   +2 more
core  

Muscarinic receptor subtypes in the alimentary tract

, 2009
Acetylcholine is a transmitter in preganglionic autonomic and postganglionic parasympathetic nerves and a non-neuronal paracrine mediator in the alimentary tract. Acetylcholine is involved in the control of almost any function within these organ systems,
Tobin, Gunnar,, Lundgren, Ove,, Giglio, Daniel,   +2 more
core  

Muscarinic acetylcholine receptor M3 (CHRM3; HM3) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Muscarinic acetylcholine receptor M3 (CHRM3; HM3) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Physiological Significance of Endothelial M3 Muscarinic Receptors During Exercise

Circulation Research
Gareth L. Ackland, Patrick S. Hosford, Ana Gutierrez del Arroyo, Alla Korsak, Asif Machhada, Jack Pickard, Genoveva Gomez Gomez De La Torre, Daniel J. Stuckey, Andrew Tinker, Andrew B. Tobin, Jongrye Jeon, Jürgen Wess, Alexander V. Gourine   +12 more
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Muscarinic M3 receptor coupling and regulation

Life Sciences, 1997
Current concepts regarding the regulation and coupling of muscarinic m3 receptors to G-proteins and various effectors are discussed. The last few years have provided much evidence that although muscarinic m1, m3 and m5 subtypes couple predominantly via pertussis toxin-insensitive G-proteins (Gq/11) to activate phosphoinositidase C (PIC), interactions ...
S R, Nahorski, A B, Tobin, G B, Willars
openaire   +2 more sources

m3 Muscarinic Acetylcholine Receptor Regulation in the Airway

American Journal of Respiratory Cell and Molecular Biology, 2002
The m3 muscarinic acetylcholine receptor (m3 mAChR) plays an important role in airway function by mediating the effects of acetylcholine on multiple airway cell types. m3 mAChRs expressed in airway smooth muscle (ASM) cells promote increased ASM tension, and, therefore, airway narrowing, in response to acetylcholine release from postganglionic ...
Charlotte K, Billington, Raymond B, Penn
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M1 and M3 muscarinic receptors

NeuroReport, 1992
P-fluoro-hexahydro-sila-difenidol hydrochloride (p-F-HHSiD) (15, 30 micrograms) and pirenzepine (7.5, 15, 30 micrograms), which are highly selective M3 and M1 muscarinic antagonists, respectively, were injected intracerebroventricularly into freely moving rats.
L. IMERI, S. BIANCHI, P. ANGELI, M. MANCIA   +3 more
openaire   +3 more sources

Synthesis of antagonists of muscarinic (M3) receptors

Collection of Czechoslovak Chemical Communications, 2011
Several α-hydroxyamides with (2,6-dialkoxyphenoxy)methyl substituents have been prepared and their activities as antagonists of the M3 muscarinic receptor in guinea pig ileum have been evaluated. N-{1-[(Phenyl)methyl]piperidin-4-yl}-2-{2-[(2,6-dimethoxyphenoxy)-methyl]phenyl}-2-hydroxypropanamide and N-(1-[{6-amino-4-[(1-propylpiperidin-4-yl)methyl ...
Broadley, Kenneth J., Davies, Robin H., Escargueil, Christine, Lee, Alan T L, Penson, Peter, Thomas, Eric J.   +5 more
openaire   +2 more sources