Results 61 to 70 of about 1,546 (109)

Human M3 muscarinic acetylcholine receptor protein-protein interactions: roles in receptor signaling and regualation [PDF]

, 2008
Muscarinic acetylcholine receptors (mAChRs) have been shown to mediate various functions in the central and peripheral nervous systems. These include modulation of exocrine glandular secretion, vasodilatation and smooth muscle contraction, cell ...
Borroto Escuela, Dasiel Oscar
core   +1 more source

MUSCARINIC M1 AND M3 RECEPTOR GENE EXPRESSION DURING PANCREATIC REGENERATION AND INSULIN SECRETION IN RATS

, 2003
The present work is an attempt to understand the role of acetylcholine muscarinic M1 and M3 receptors during pancreatic regeneration and insulin secretion. The work focuses on the changes in the muscarinic M1 and M3 receptors in brain and pancreas during
Paulose,C S, Renuka, T R
core  

α-Helical distorting substitutions disrupt coupling between m3 muscarinic receptor and G proteins

, 1993
Acetylcholine stimulation of the m3 or m2 muscarinic receptor expressed in Xenopus laevis oocytes induces either a fast transient or slowly oscillating calcium-sensitive chloride current.
David Clapham, Carroll, Reed, Kevin Duerson, Clapham, David, Duerson, Kevin, Reed Carroll   +5 more
core   +1 more source

Allosteric interactions at the m1, m2 and m3 muscarinic receptor subtypes

, 1991
The purpose of our study was to investigate the interactions of allosteric antagonists at the individual m1, m2 and m3 muscarinic receptor subtypes. This was achieved through the use of transformed Chinese hamster ovary cells stably expressing the rat m1
Lee, N. H., El-Fakahany, E. E.
core  

Phosphorylation of a phosphoinositidase C-linked muscarinic receptor by a novel kinase distinct from β-adrenergic receptor kinase

, 1993
Muscarinic receptor kinase activity previously described in intact CHO cells transfected with human m3-muscarinic receptor cDNA (CHO-m3 cells) [Tobin, A.B and Nahorski, S.R (1993) J. Biol. Chem.
Keys, B., B. Keys, S.R. Nahorski, A.B. Tobin, Tobin, A.B., Nahorski, S.R.   +5 more
core   +1 more source

On the Autonomic Control of Blood Flow and Secretion in Salivary Glands. Functional and morphological aspects on muscarinic receptor subtypes in different species.

, 2008
Parasympathetic nervous activity is the principal stimulus for evoking fluid responses within salivary glands. Concomitantly to the onset of this response, the blood flow increases.
Ryberg, Anders T
core  

Expression of muscarinic receptor subtypes and M2-muscarinic inhibition of adenylyl cyclase in lung

, 1995
The relative distribution and absolute quantities of muscarinic receptor subtypes m1, m2, m3, and m4 were determined in membranes of canine trachealis muscle, bronchi, and lung parenchyma by immuno-precipitation with receptor subtype-specific rabbit ...
C. W. Emala, A. Aryana, B. B. Wolfe, R. P. Yasuda, C. A. Hirshman, S. A. Satkus, M. A. Levine   +6 more
core   +1 more source

Increased Insulin Secretion by Muscarinic M1 and M3 Receptor Function from Rat Pancreatic Islets in vitro

, 2005
Parasympathetic system plays an important role in insulin secretion from the pancreas. Cholinergic effect on pancreatic beta cells exerts primarily through muscarinic receptors.
Paulose,C S, Remya, Robinson, Renuka, T R   +2 more
core  

Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq

Communications Biology
AbstractMuscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets due to their involvement in physiopathological processes. Although the structure of the M3-miniGq complex was recently published, the lack of information on the intracellular loop 3 (ICL3) of M3 and extensive modification of Gαq ...
Donghee Ham, Asuka Inoue, Jun Xu, Yang Du, Ka Young Chung   +4 more
openaire   +3 more sources

H]‐methylscopolamine afford differential labeling and localization of M1, M2, and M3 muscarinic receptor subtypes in primate brain

, 1993
Three classes of muscarinic receptors in mammalian brain have been postulated on the basis of equilibrium and kinetic binding data. However, equilibrium binding assays alone have not permitted a clear demonstration of the localization of putative M1, M2,
Deborah C. Mash, Flynn, D D, Mash, D C, Donna D. Flynn   +3 more
core   +1 more source