Results 51 to 60 of about 1,546 (109)

Excitatory effects of muscarine on septohippocampal neurons: involvement of M3 receptors

Brain Research, 1998
Cholinergic mechanisms in the septohippocampal pathway contribute to several cognitive functions and impaired cholinergic transmission in this pathway may be related to the memory loss and dementia that accompanies normal aging and Alzheimer's disease and behavioral studies suggest that muscarinic mechanisms in the medial septum/diagonal band of Broca (
W, Liu, A, Kumar, M, Alreja
openaire   +2 more sources

Molecular Cloning of m3 Muscarinic Acetylcholine Receptor in Rat Iris.

Journal of Smooth Muscle Research, 1998
Muscarinic receptor subtypes that involved in cholinergic responses in rat iris were identified by reverse transcription-polymerase chain reaction (RT-PCR) analysis. mRNAs encoding m2, m3, and m4 subtypes were abundantly expressed in iris, whereas m1 and m5 subtypes were not detected.
FURUTA, Michino, OHYA, Susumu, IMAIZUMI, Yuji, WATANABE, Minoru   +3 more
openaire   +3 more sources

M 1and M 3 muscarinic receptors mediate relaxation and contraction in canine nasal veins

, 2011
Background: Acetylcholine (ACh) has been shown to induce nasal congestion via vasorelaxation of intranasal posterior collecting veins (PCV) coupled with vasocontraction of extranasal outflow veins (dorsal nasal vein [DNV] and sphenopalatine vein [SPV ...
Mary A. Lung, Lung, MA
core   +1 more source

Signal transduction by M3 muscarinic acetylcholine receptor in prostate cancer

Oncology Letters, 2015
The present study aimed to investigate the potential mechanisms used during signal transduction by M3 muscarinic acetylcholine receptor (CHRM3) in prostate cancer. The microarray datasets of GSE3325, including 5 clinically localized primary prostate cancers and 4 benign prostate tissues, were downloaded from the Gene Expression Omnibus database.
Liqiang, Guo, Yuqiang, Liu, Zhibo, Ding, Wendong, Sun, Mingzhen, Yuan   +4 more
openaire   +3 more sources

Pressor response to posterior hypothalamic administration of carbachol is mediated by muscarinic M3 receptor

, 1992
Unilateral microinjection of the acetylcholine receptor agonist carbachol into the posterior hypothalamic nucleus evokes a pressor response in the conscious, freely moving rat.
Martin, John R.
core   +1 more source

Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists [PDF]

, 2018
Drugs that treat chronic obstructive pulmonary disease by antagonizing the M3 muscarinic acetylcholine receptor (M3R) have had a significant effect on health, but can suffer from their lack of selectivity against the M2R subtype, which modulates heart ...
Bartuschat, Amelie, Sunahara, Roger K, Fisher, John T, Hirata, Kunio, Banerjee, Ashutosh, Heinrich, Markus R, Kobilka, Brian K, Liu, Xiangyu, Fish, Inbar, Schaake, Benjamin, Eitel, Katrin, Gmeiner, Peter, Shoichet, Brian K, Hofmann, Josefa, Clark, Mary J, Kaindl, Jonas, Rampp, Hannelore, Hübner, Harald, Liu, Hongtao, Vincent, Sandra G   +19 more
core   +1 more source

Time-dependent modulation of muscarinic m1/m3 receptor signalling by local anaesthetics

, 2014
Signalling of several G-protein-coupled receptors of the Gq/11 family is time-dependently inhibited by local anaesthetics (LAs). Since LA-induced modulation of muscarinic m1 and m3 receptor function may explain their beneficial effects in clinical ...
Lirk, P., Hollmann, M. W., Durieux, M. E., Picardi, S., Hahnenkamp, K., Stevens, M. F.   +5 more
core   +1 more source

Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells

, 2009
Acetylcholine is the primary parasympathetic neurotransmitter in the airways and is known to cause bronchoconstriction and mucus secretion. Recent findings suggest that acetylcholine also regulates aspects of remodelling and inflammation through its ...
Ninaber, D. K., Kolahian, S., Gosens, R., Hiemstra, P. S., Halayko, A. J., Meurs, H., Rabe, K. F., Zuyderduyn, S., Rieks, D., Nanninga, J.   +9 more
core   +1 more source

Anti-M3 muscarinic acetylcholine receptor antibodies and Sjögren's syndrome

Japanese Journal of Clinical Immunology, 2013
Sjögren's syndrome (SS) is an autoimmune disease that affects exocrine glands including salivary and lacrimal glands. It is characterized by lymphocytic infiltration into exocrine glands, leading to dry mouth and eyes. A number of auto-antibodies are detected in patients with SS. However, no SS-specific pathologic auto-antibodies have yet been found in
TSUBOI, Hiroto, IIZUKA, Mana, ASASHIMA, Hiromitsu, SUMIDA, Takayuki   +3 more
openaire   +3 more sources

Localisation of muscarinic receptor M1-M3 immunoreactivity in human colon

, 2006
Physiological, pharmacological, radioligand binding and in-situ hybridisation studies show human intestine has M1, M2 and M3 muscarinic receptor subtypes, but the precise localisation of receptor subtypes is not known due to lack of specific antibodies ...
Møller, Flemming Vejby, Buntzen, S., Harrington, A., Laurberg, S., Rijkhoff, Nico   +4 more
core   +1 more source