Results 71 to 80 of about 1,546 (109)

The third intracellular domain of the m3 muscarinic receptor determines coupling to calcium influx in transfected Chinese hamster ovary cells

, 1996
The m2 and m3 muscarinic acetylcholine receptors were expressed in CHO cells and were shown to couple to the release of calcium from intracellular stores. The m3 receptor, but not the m2 receptor, also coupled to calcium influx.
Liu, Jie, Jurgen Wess, Christian C. Felder, Wess, Jurgen, Jie Liu, Felder, Christian C., Dafna Singer-Lahat, Singer-Lahat, Dafna   +7 more
core   +1 more source

Muscarinic Agonist-Mediated Heterologous Desensitization in Isolated Ileum Requires Activation of Both Muscarinic M2 and M3 Receptors

, 2004
We investigated the subtypes of the muscarinic receptor mediating short-term heterologous desensitization in the isolated ileum. Treatment of the ileum from C57BL/6 mice with acetylcholine (30 μM) for 20 min caused a subsequent decrease in contractile ...
Shehnaz, Darakhshanda, Ansari, Khurram Z., Taketo, Makoto M., Griffin, Michael T., Ehlert, Frederick J., Manabe, Toshiya, Matsui, Minoru   +6 more
core   +1 more source

Muscarinic M3 receptor (CHRM3) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Muscarinic receptor subtype mediating vasodilation feline middle cerebral artery exhibits M3 pharmacology.

, 1990
International audienceThe nature of the muscarinic receptor subtype mediating the endothelium-dependent relaxation of the cat middle cerebral artery was investigated in vitro by recording the smooth muscle isometric tension of precontracted arterial ...
Dauphin, François, Hamel, Edith
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Clathrin-mediated Endocytosis of m3 Muscarinic Receptors [PDF]

Journal of Biological Chemistry, 2004
Juliana S. Popova, Mark M. Rasenick
openaire   +1 more source

Lack of receptor selective effects of either RGS2, RGS3 or RGS4 on muscarinic M3- and gonadotropin-releasing hormone-receptor-mediated signalling through Gαq/11

, 2008
Termination of signalling by G-protein-coupled receptors requires inactivation of the Gα-subunits of heterotrimeric G-proteins and the re-association of Gα- and Gβγ-subunits.
Gary B. Willars (7128650), Paul J. Brighton (7584677), Stephen C. Tovey (286869), Aikaterini Karakoula (7584674)   +3 more
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Effect of the ligand in the Modeling the 3d structure of the m3 muscarinic receptor

There are still many question open to completely understand the structure-activity relationships of G-protein coupled receptors. Issues like the actual mapping of the binding site of different subtypes, as well as the mechanism of activation are poorly ...
Rasaeifar, Bahareh
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Paired activation of the two components within muscarinic M3 receptor dimers is required for recruitment of beta-arrestin-1 to the plasma membrane

, 2005
-Arrestins regulate the functioning of G protein-coupled receptors in a variety of cellular processes including receptor-mediated endocytosis and activation of signaling molecules such as ERK.
STANASILA L, GIORGI F, NOVI F., CORSINI GU, MAGGIO, Roberto, COTECCHIA S   +5 more
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Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens

, 2013
During the last decade, cholinergic signaling via acetylcholine and its receptors has emerged as an important regulator of immunity. Acetylcholine binds to and signals through two types of receptors; nicotinic and muscarinic receptors. Studies have shown
Vira, Alykhan
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Signalling and receptor crosstalk mediated by full and partial agonists of the muscarinic M3 receptor

, 2006
This study shows that stimulation of endogenously expressed Galpha q/11-coupled muscarinic M3 receptors in HEK 293 cells allows a subsequent robust Ca2+ response to stimulation of beta 2-adrenoceptors.
Nisha Kurian (94350)
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