Results 11 to 20 of about 18,745 (209)

Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq

Communications Biology
Muscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets due to their involvement in physiopathological processes.
Donghee Ham, Asuka Inoue, Jun Xu, Yang Du, Ka Young Chung   +4 more
doaj   +3 more sources

Synthesis and Evaluation of Fluorinated Peptidomimetics Enabling the Development of ¹⁸F-Labeled Radioligands Targeting Muscarinic Acetylcholine Receptor Subtype M3. [PDF]

ChemMedChem
Fluorinated peptidomimetics targeting muscarinic acetylcholine receptor subtype M3: Fluorinated peptidomimetic compounds based on a β‐alanine‐glycine scaffold, with lead compound 24 demonstrating high M3 selectivity and submicromolar potency. The first M3‐selective positron emission tomography radioligand, [18F]24, is synthesized and will be evaluated ...
Herrera-Rueda MA, Boateng MA, Wuest M, West FG, Wuest F.   +4 more
europepmc   +2 more sources

Exploring Adjunctive Novel Therapeutic Approach of KarXT (Xanomeline-Trospium Chloride) for Managing Psychotic Symptoms in Patients With Schizophrenia and Alzheimer's Disease. [PDF]

Brain Behav
An overview of the mechanism of action, clinical trials, and classical findings of KarXT for the management of psychotic symptoms in patients with schizophrenia and alzheimer's disease. ABSTRACT Background Acute psychotic symptoms like delusions and hallucinations are of major concern while treating patients with schizophrenia and alzheimer's psychosis,
Kanwal A, Azeem B, Nasir H, Mumtaz F, Ashraf N, Amin MHJ, Kanwal W, Khan BW.   +7 more
europepmc   +2 more sources

The M3 Muscarinic Acetylcholine Receptor Promotes Epidermal Differentiation

Journal of Investigative Dermatology, 2022
The M3 muscarinic acetylcholine receptor is predominantly expressed in the basal epidermal layer where it mediates the effects of the autocrine/paracrine cytotransmitter acetylcholine. Patients with the autoimmune blistering disease pemphigus develop autoantibodies to M3 muscarinic acetylcholine receptor and show alterations in keratinocyte adhesion ...
Junyan Duan, Charles Grando, Shuman Liu, Alex Chernyavsky, Jefferson K. Chen, Bogi Andersen, Sergei A. Grando   +6 more
openaire   +4 more sources

Physiological Significance of Endothelial M3 Muscarinic Receptors During Exercise. [PDF]

Circ Res
Ackland GL, Hosford PS, Gutierrez Del Arroyo A, Korsak A, Machhada A, Pickard J, Gomez De La Torre GG, Stuckey DJ, Tinker A, Tobin AB, Jeon J, Wess J, Gourine AV.   +12 more
europepmc   +2 more sources

Targeting M3 Muscarinic Receptors for Colon Cancer Therapy [PDF]

Current Molecular Pharmacology, 2018
Expression and activation of subtype-3 muscarinic receptors (M3R) plays an important role in the progression of colorectal neoplasia.Herein, we describe the role of muscarinic receptors in colon cancer, focusing specifically on M3R, illustrate how M3R over-expression and activation of post-receptor signaling pathways potentiates tumor progression, and ...
Jessica, Felton, Shien, Hu, Jean-Pierre, Raufman   +2 more
openaire   +2 more sources

Expression of M3 muscarinic acetylcholine receptors in gastric cancer

Romanian Journal of Morphology and Embryology, 2022
Gastric cancer represents a real public health problem as far as incidence, aggressiveness and unfavorable prognosis are concerned. The autonomous nervous system might be one of the major factors involved in the onset, progression, and metastasis, both sympathetically and parasympathetically.
Mehedinţeanu, Alina Maria, Mirea, Cecil Sorin, Stovicek, Puiu Olivian, Schenker, Michael, Stancu, Marius Ionuţ, Ciurea, Ana-Maria, Streba, Liliana, Istrate-Ofiţeru, Anca-Maria, Sas, Teodor-Nicuşor, Vere, Cristin Constantin   +9 more
openaire   +2 more sources

Characterization of Bladder Selectivity of Antimuscarinic Agents on the Basis of Drug-Receptor Binding [PDF]

International Neurourology Journal, 2012
The in vivo muscarinic receptor binding of antimuscarinic agents (oxybutynin, solifenacin, tolterodine, and imidafenacin) used to treat urinary dysfunction in patients with overactive bladder is reviewed.
Shizuo Yamada, Shiori Kuraoka, Ayaka Osano, Yoshihiko Ito   +3 more
doaj   +1 more source

Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models. [PDF]

, 2016
Pulmonary hypertension (PH) is a complex disease comprising a pathologic remodeling and thickening of the pulmonary vessels causing an after load on the right heart ventricle that can result in ventricular failure. Triggered by oxidative stress, episodes
Ahmed, Mohamed, Al-Abed, Yousef, Coleman, Thomas, Lakshminrusimha, Satyanarayana, Patel, Hardik, VanPatten, Sonya   +5 more
core   +2 more sources

Carbachol Induces Ca2+-Dependent Contraction via Muscarinic M2 and M3 Receptors in Rat Intestinal Subepithelial Myofibroblasts

Journal of Pharmacological Sciences, 2009
.: Intestinal myofibroblasts (IMFs) that exist adjacent to the basement membrane of intestines have contractility and contribute to physical barriers of the intestine.
Koichi Iwanaga, Takahisa Murata, Muneyoshi Okada, Masatoshi Hori, Hiroshi Ozaki   +4 more
doaj   +1 more source