Results 21 to 30 of about 1,546 (109)

Signalling of the M3-muscarinic receptor to the anti-apoptotic pathway [PDF]

Biochemical Journal, 2004
The process of programmed cell death (or apoptosis) occurs widely in tissue maintenance and embryonic development, and is under tight regulatory control. It is now clear that one of the important regulators of apoptosis are G-protein-coupled receptors.
Budd, DC, Spragg, EJ, Ridd, K, Tobin, AB
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Muscarinic receptor M3 activation promotes fibrocytes contraction

Frontiers in Pharmacology, 2022
Fibrocytes are monocyte-derived cells able to differentiate into myofibroblasts-like cells. We have previously shown that they are increased in the bronchi of Chronic Obstructive Pulmonary Disease (COPD) patients and associated to worse lung function.
Pauline Henrot, Pauline Henrot, Edmée Eyraud, Elise Maurat, Sophie Point, Guillaume Cardouat, Jean-François Quignard, Pauline Esteves, Thomas Trian, Pierre-Olivier Girodet, Pierre-Olivier Girodet, Pierre-Olivier Girodet, Roger Marthan, Roger Marthan, Maéva Zysman, Maéva Zysman, Patrick Berger, Patrick Berger, Patrick Berger, Isabelle Dupin   +19 more
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Identification and Molecular Characterization of m3 Muscarinic Receptor Dimers [PDF]

Journal of Biological Chemistry, 1999
Several studies suggest, but do not prove directly, that muscarinic receptors may be able to form dimeric or oligomeric arrays. To address this issue in a more direct fashion, we designed a series of biochemical experiments using a modified version of the rat m3 muscarinic receptor (referred to as m3') as a model system.
F Y, Zeng, J, Wess
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The interaction of tiotropium with long lasting β2-agonists on lung cell function [PDF]

, 2013
The major question addressed in this thesis was to find the mechanism(s) by which muscarinic receptors interact with β2-adrenergic receptors in human airway fibroblasts.
Costa, Luigi
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The Effects of the Selective Muscarinic M3 Receptor Antagonist Darifenacin, and of Hyoscine (scopolamine), on Motion Sickness, Skin Conductance & Cognitive Function [PDF]

, 2018
Aims: The aim of this study was to compare the effects of the selective M3 muscarinic acetylcholine receptor antagonist Darifenacin, oral Hyoscine hydrobromide and Placebo on motion sickness induced by cross-coupled stimulation.
Brian R. Leaker, Leaker, B.R., Wesnes, K.A., John F. Golding, Keith A. Wesnes, Golding, J.F.   +5 more
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Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET [PDF]

, 2010
Flp-In T-REx 293 cells expressing a wild type human M muscarinic acetylcholine receptor construct constitutively and able to express a Receptor Activated Solely by Synthetic Ligand (RASSL) form of this receptor on demand maintained response to the ...
Alvarez-Curto, Elisa, Ward, Richard J., Milligan, Graeme, Pediani, John D.   +3 more
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Expression of muscarinic acetylcholine receptors M3 and M5 in osteoporosis [PDF]

Medical Science Monitor, 2014
Cholinergic signaling via muscarinic acetylcholine receptors (mAChR) is known to influence various physiological functions. In bone, M3 mAChR and M5 mAChR were identified on the membrane of osteoblast-like cells. M3 mAChR seems to be particularly relevant for bone physiology, as signaling via this receptor was reported to increase bone formation and ...
Kauschke, Vivien, Lips, Katrin Susanne, Heiss, Christian, Schnettler, Reinhard   +3 more
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Structure and dynamics of the M3 muscarinic acetylcholine receptor [PDF]

Nature, 2012
Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subtypes (M1-M5) share a high degree of sequence homology, they show pronounced differences in G-protein ...
Kruse, Andrew C., Hu, Jianxin, Pan, Albert C., Arlow, Daniel H., Rosenbaum, Daniel M., Rosemond, Erica, Green, Hillary F., Liu, Tong, Chae, Pil Seok, Dror, Ron O., Shaw, David E., Weis, William I., Wess, Jurgen, Kobilka, Brian   +13 more
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Eosinophil-mediated cholinergic nerve remodeling [PDF]

, 2006
Eosinophils are observed to localize to cholinergic nerves in a variety of inflammatory conditions such as asthma, rhinitis, eosinophilic gastroenteritis, and inflammatory bowel disease, where they are also responsible for the induction of cell ...
McLean, W.G., Anthony G. Fenech, Madziar, B., Madziar, Beata, Durcan, Niamh, Gleich, G.J., Walsh, M., Fenech, Anthony G., McLean, Graham W., Jan Blusztajn, Gerard J. Gleich, Gleich, Gerard J., Niamh Durcan, Hall, Ian P., Beata Madziar, Walsh, Marie-Therese, Hall, I.P., Ian P. Hall, Durcan, N., Costello, Richard W., Richard W. Costello, Marie-Therese Walsh, McGarvey, Lorcan, Costello, R.W., Fenech, A.G., W. Graham McLean, Lorcan McGarvey, Blusztain, J., Blusztajn, Jan   +28 more
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Muscarinic acetylcholine receptor m3 mutation causes urinary bladder disease and a prune-belly-like syndrome [PDF]

, 2011
Urinary bladder malformations associated with bladder outlet obstruction are a frequent cause of progressive renal failure in children. We here describe a muscarinic acetylcholine receptor M3 (CHRM3) (1q41-q44) homozygous frameshift mutation in familial ...
Woolf, A.S., Sozeri, Betül, Mohammad Reza Toliat, Thiele, H., Schaefer, F., Konrad, Martin, Woolf, Adrian S.; id_orcid, William G. Newman, Altmüller, Janine, Duncan T. Wilcox, Stefanie Weber, Neil A. Hanley, Schlingmann, Karl Peter, Betül Sozeri, Jennings, Rachel, Thiel, U., Thiele, Holger, Stuart, Helen M., Janine Altmüller, Reutter, H., Nürnberg, P., Peter Frommolt, Uwe Thiel, Frommolt, P., Frommolt, Peter, Franz Schaefer, Mir, S., Reutter, Heiko, Adrian S. Woolf, Karl Peter Schlingmann, Michael Ludwig, Martin Konrad, Ludwig, Michael, Woolf, Adrian S., Schlingmann, K.P., Newman, William G., Sozeri, B., Hoyer, Peter F., Toliat, M.R., Stuart, H.M, Jennings, R., Hanley, Neil A., Hoyer, P.F., Schaefer, Franz, Rolf Beetz, Markus Draaken, Ranjzad, P., Helen M. Stuart, Weber, Stefanie, Toliat, Mohammad Reza, Draaken, M., Hanley, Neil A.; id_orcid, Beetz, Rolf, Parisa Ranjzad, Rachel Jennings, Hanley, N.A., Heiko Reutter, Draaken, Markus, Mir, Sevgi, Nürnberg, Peter, Peter Nürnberg, Thiel, Uwe, Holger Thiele, Newman, W.G., Wilcox, D.T., Peter F. Hoyer, Ludwig, M., Altmüller, J., Konrad, M., Wilcox, Duncan T., Beetz, R., Ranjzad, Parisa, Newman, William G.; id_orcid, Sevgi Mir, Weber, S.   +74 more
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