Results 11 to 20 of about 1,546 (109)
The M3 Muscarinic Acetylcholine Receptor Promotes Epidermal Differentiation [PDF]
Journal of Investigative Dermatology, 2022 The M3 muscarinic acetylcholine receptor is predominantly expressed in the basal epidermal layer where it mediates the effects of the autocrine/paracrine cytotransmitter acetylcholine.
Jefferson K. Chen +15 more
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Localization of muscarinic M3 receptor protein and M3 receptor binding in rat brain [PDF]
Neuroscience, 1994 A family of receptor subtypes, defined either by molecular (ml-m5) or pharmacological (M1-M4) analysis, mediates muscarinic cholinergic neurotransmission in brain.
Frey, Kirk A. +4 more
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Inhibition of m3 muscarinic acetylcholine receptors by local anaesthetics [PDF]
British Journal of Pharmacology, 2001 1. Muscarinic m1 receptors are inhibited by local anaesthetics (LA) at nM concentrations. To elucidate in more detail the site(s) of LA interaction, we compared these findings with LA effects on m3 muscarinic receptors. 2.
Manuela De Klaver +11 more
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Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency [PDF]
Cell Metabolism, 2006 SummaryMost animal models of obesity and hyperinsulinemia are associated with increased vagal cholinergic activity. The M3 muscarinic acetylcholine receptor subtype is widely expressed in the brain and peripheral tissues and plays a key role in mediating
Jou, William +7 more
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Allosteric interactions at the M3 muscarinic acetylcholine receptor [PDF]
, 2008 The extracellular loops of muscarinic acetylcholine receptors are predicted to play a role in the binding and regulation of allosteric modulators. Furthermore, the sequence of the five subtypes of muscarinic receptors shows a large degree of diversity in
Iarriccio Silva, Laura
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The Role of Muscarinic Acetylcholine Receptor M3 in Cardiovascular Diseases
International Journal of Molecular SciencesThe muscarinic acetylcholine receptor M3 (M3-mAChR) is involved in various physiological and pathological processes. Owing to specific cardioprotective effects, M3-mAChR is an ideal diagnostic and therapeutic biomarker for cardiovascular diseases (CVDs).
Min Zhang +4 more
core +3 more sources
A novel clinical syndrome revealing a deficiency of the muscarinic M3 receptor.
Neurology, 2011 Objectives: No clinical disorders have been caused by dysfunction of any of the 5 subtypes (M1– M5) of muscarinic receptors. We present a patient with a novel clinical syndrome that we suggest results from a deficiency of the muscarinic M3 receptor ...
Haensch CA +8 more
core +4 more sources
Expression of M3 muscarinic acetylcholine receptors in gastric cancer
Romanian Journal of Morphology and Embryology, 2022 Gastric cancer represents a real public health problem as far as incidence, aggressiveness and unfavorable prognosis are concerned. The autonomous nervous system might be one of the major factors involved in the onset, progression, and metastasis, both sympathetically and parasympathetically.
Mehedinţeanu, Alina Maria +9 more
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Targeting M3 Muscarinic Receptors for Colon Cancer Therapy [PDF]
Current Molecular Pharmacology, 2018 Expression and activation of subtype-3 muscarinic receptors (M3R) plays an important role in the progression of colorectal neoplasia.Herein, we describe the role of muscarinic receptors in colon cancer, focusing specifically on M3R, illustrate how M3R over-expression and activation of post-receptor signaling pathways potentiates tumor progression, and ...
Jessica, Felton +2 more
openaire +2 more sources
Physiological functions of muscarinic receptor M3 [PDF]
, 2023 Muscarinic receptors belong to the family of G-protein coupled receptors. G-proteins are heterotrimeric GTP-binding proteins that transfer signals from receptors to effectors. Effectors change levels of second messengers in the cell.
Urbánková, Anna
core +1 more source