Results 11 to 20 of about 410,064 (307)

Expression of protease activating receptor-2 (PAR-2) is positively correlated with the recurrence of non-muscle invasive bladder cancer: an immunohistochemical analysis

Research and Reports in Urology, 2019
Kozue Nakahara,1 Koji Yamasaki,1 Takahiro Nagai,1 Masato Fujii,1 Takahiro Akioka,1 Hiroki Takamori,1 Naoki Terada,1 Shoichiro Mukai,1 Yuichiro Sato,2 Toshiyuki Kamoto11Department of Urology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan ...
Nakahara K, Yamasaki K, Nagai T, Fujii M, Akioka T, Takamori H, Terada N, Mukai S, Sato Y, Kamoto T   +9 more
doaj   +1 more source

Transcriptional regulation of the urokinase receptor (u-PAR) - A central molecule of invasion and metastasis [PDF]

, 2003
The phenomenon of tumor-associated proteolysis has been acknowledged as a decisive step in the progression of cancer. This short review focuses on the urokinase receptor (u-PAR), a central molecule involved in tumor-associated invasion and metastasis ...
Fuchs, T., Allgayer, H.
core   +1 more source

Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis [PDF]

, 2010
<b>Objective:</b> Osteoarthritis is a global clinical challenge for which no effective disease-modifying agents currently exist. This study identified protease-activated receptor 2 (PAR-2) as a novel pathogenic mechanism and potential ...
McInnes, I.B., Lockhart, J.C., Plevin, R., Elizabeth B Kelso, Robin Plevin, Iain B McInnes, Ferrell, W.R., Kelso, E.B., Plevin, R.J., William R Ferrell, John C Lockhart   +10 more
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Optical biosensor differentiates signaling of endogenous PAR₁ and PAR₂ in A431 cells

BMC Cell Biology, 2007
Background Protease activated receptors (PARs) consist of a family of four G protein-coupled receptors. Many types of cells express several PARs, whose physiological significance is mostly unknown.
Ferrie Ann M, Fang Ye
doaj   +1 more source

Thrombin-Stimulated Proliferation of Cultured Human Synovial Fibroblasts Through Proteolytic Activation of Proteinase-Activated Receptor-1

Journal of Pharmacological Sciences, 2008
We examined the mechanism of thrombin on proliferation of synovial fibroblasts obtained from rheumatoid arthritis (RA). Thrombin concentration-dependently induced proliferation of synovial fibroblasts. Proliferation in response to thrombin (10 U /ml) was
Ikue Furuhashi, Kazuki Abe, Toshitsugu Sato, Hideo Inoue   +3 more
doaj   +1 more source

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): PAR-2-Mediated Proliferation of Colon Cancer Cell

Journal of Pharmacological Sciences, 2005
Proteinase-activated receptor-2 (PAR-2) has been demonstrated to be highly expressed in the gastrointestinal tract. In the present minireview, we summarize the effects of PAR-1 and PAR-2 stimulation using their activating peptides and agonist proteinases
Masahiro Nishibori, Shuji Mori, Hideo K. Takahashi   +2 more
doaj   +1 more source

Glucagon-like peptide-1 receptor imaging for localization of insulinomas [PDF]

, 2009
The surgical removal of insulinomas is hampered by difficulties to localize it using conventional radiological procedures. Recently these tumors were shown to exhibit a very high density of glucagon-like peptide-1 receptors (GLP-1R) in vitro that may be ...
Clerici, Thomas, Forrer, Flavio, Gloor, Beat, Reubi, Jean Claude, Rahel Sahli, Mäcke, Helmut R., Brändle, Michael, Beat Gloor, Martius, Ferdinand, Damian Wild, Reubi, Jean-Claude, Thomas Clerici, Flavio Forrer, Maecke, Helmut, Wild, Damian, Emanuel Christ, Ferdinand Martius, Christ, Emanuel, Sahli, Rahel, Jean Claude Reubi, Michael Brändle, Helmut Maecke   +21 more
core   +1 more source

Galectin-3 facilitates cell motility in gastric cancer by up-regulating protease-activated receptor-1 (PAR-1) and matrix metalloproteinase-1 (MMP-1).

PLoS ONE, 2011
BackgroundGalectin-3 is known to regulate cancer metastasis. However, the underlying mechanism has not been defined. Through the DNA microarray studies after galectin-3 silencing, we demonstrated here that galectin-3 plays a key role in up-regulating the
Seok-Jun Kim, Ji-Young Shin, Kang-Duck Lee, Young-Ki Bae, Il-Ju Choi, Seok Hee Park, Kyung-Hee Chun   +6 more
doaj   +1 more source

A PAR-1-dependent orientation gradient of dynamic microtubules directs posterior cargo transport in the Drosophila oocyte [PDF]

, 2011
Cytoskeletal organization is central to establishing cell polarity in various cellular contexts, including during messenger ribonucleic acid sorting in Drosophila melanogaster oocytes by microtubule (MT)-dependent molecular motors.
Lu, Weiping, Hamilton, RS, Hamilton, R, C. Fiona Cullen, Weiping Lu, Parton, Richard M., Cullen, CF, Parton, R, Ball, G, Ohkura, Hiroyuki, Yang, L, Lei Yang, Ilan Davis, Davis, Ilan, Parton, RM, Russell S. Hamilton, Hamilton, Russell S., Ohkura, H, Cullen, C. Fiona, Richard M. Parton, Graeme Ball, Yang, Lei, Hiroyuki Ohkura, Davis, I, Cullen, Fiona, Ball, Graeme, Lu, W   +26 more
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Mast Cell Tryptase Stimulates DLD-1 Carcinoma Through Prostaglandin- and MAP Kinase-Dependent Manners

Journal of Pharmacological Sciences, 2005
We found that striptease-positive mast cells were abundant in the invasive front of human colon adenocarcinoma by examining 30 cases. Because tryptase has been suggested to be the agonist proteinase for protease-activated receptor-2 (PAR-2), we ...
Masanori Yoshii, Atsushi Jikuhara, Shuji Mori, Hiromi Iwagaki, Hideo K. Takahashi, Masahiro Nishibori, Noriaki Tanaka   +6 more
doaj   +1 more source