Results 21 to 30 of about 410,064 (307)
Granzyme B-induced neurotoxicity is mediated via activation of PAR-1 receptor and Kv1.3 channel. [PDF]
PLoS ONE, 2012 Increasing evidence supports a critical role of T cells in neurodegeneration associated with acute and subacute brain inflammatory disorders. Granzyme B (GrB), released by activated T cells, is a cytotoxic proteinase which may induce perforin-independent
Tongguang Wang +7 more
doaj +1 more source
Research and Practice in Thrombosis and Haemostasis, 2020 Background Blood coagulation protease activity is proposed to drive hepatic fibrosis through activation of protease‐activated receptors (PARs). Whole‐body PAR‐1 deficiency reduces experimental hepatic fibrosis, and in vitro studies suggest a potential ...
Lauren G. Poole +6 more
doaj +1 more source
Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2and cell proliferationviaGαq-mediated mechanism [PDF]
, 2014 Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Cai, X +9 more
core +1 more source
Italian Journal of Medicine, 2013 Antiplatelet drugs are the cornerstone of treatment for patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention. Clopidogrel and aspirin improve long-term vascular clinical outcomes in these patients and have become a ...
Gianluca Airoldi, Mauro Campanini
doaj +1 more source
Scientific Reports, 2021 Sphingosine 1-phosphate (S1P) is a bioactive signalling sphingolipid that is increased in diseases such as obesity and diabetes. S1P can modulate platelet function, however the direction of effect and S1P receptors (S1PRs) involved are controversial ...
Haonan Liu +5 more
doaj +1 more source
Calcium homeostasis and role of ryanodine receptor type 1 (RyR1) in immune cells [PDF]
, 2010 Ryanodine receptors are intracellular Ca2+ release channels located in the membrane of the Endoplasmatic/Sarcoplasmatic Reticulum. Ryanodine receptor 1 isoform is preferentially expressed in skeletal muscle where it is responsible for release of Ca2 ...
Vukcevic, Mirko
core +1 more source
Biochemistry and Biophysics Reports, 2017 Background: Protease-activated receptor-1 (PAR-1) potentiates diabetic nephropathy (DN) as evident from reduced kidney injury in diabetic PAR-1 deficient mice. Although thrombin is the prototypical PAR-1 agonist, anticoagulant treatment does not limit DN
Maaike Waasdorp +2 more
doaj +1 more source
PAR-1 Expression in Chronic Subdural Hematoma: Potential Association with Vascular Permeability
Neurotrauma ReportsChronic subdural hematoma (CSDH) is a common neurosurgical disease in the elderly, characterized by inflammation, neovascularization, and increased vascular permeability.
Wataru Shimohigoshi +11 more
doaj +1 more source
Increased expression of protease-activated receptor 1 (PAR-1) in human leukemias
Blood Cells, Molecules, and Diseases, 2011 Protease-activated receptor 1 (PAR-1) is a G-protein-coupled receptor that is overexpressed in solid tumors, being associated with several pro-tumoral responses including primary growth, invasion, metastasis and angiogenesis. Expression of PAR-1 in human leukemic cell lines is reported but the status of its expression in human leukemic patients is ...
Veiga, Camilla de S.B. +10 more
openaire +2 more sources
Zyxin is involved in thrombin signaling via interaction with PAR‐1 receptor
The FASEB Journal, 2009 ABSTRACT Protease‐activated receptor 1 (PAR‐1) mediates thrombin signaling in human endothelial cells. As a G‐protein‐coupled receptor, PAR‐1 transmits thrombin signal through activation of the heterotrimeric G proteins, Gi, Gq, and G12/13. In this study, we demonstrated that zyxin, a LIM‐domain‐containing protein,
Jingyan, Han +4 more
openaire +3 more sources